Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Lamees Hegazy"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract REV-ERBα, a therapeutically promising nuclear hormone receptor, plays a crucial role in regulating various physiological processes such as the circadian clock, inflammation, and metabolism. However, the availability of chemical probes to in
Externí odkaz:
https://doaj.org/article/4b2eead9e4ac42958433a47b233c4d7e
Autor:
Edin Muratspahić, Kristine Deibler, Jianming Han, Nataša Tomašević, Kirtikumar B. Jadhav, Aina-Leonor Olivé-Marti, Nadine Hochrainer, Roland Hellinger, Johannes Koehbach, Jonathan F. Fay, Mohammad Homaidur Rahman, Lamees Hegazy, Timothy W. Craven, Balazs R. Varga, Gaurav Bhardwaj, Kevin Appourchaux, Susruta Majumdar, Markus Muttenthaler, Parisa Hosseinzadeh, David J. Craik, Mariana Spetea, Tao Che, David Baker, Christian W. Gruber
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Despite the increasing number of GPCR structures and recent advances in peptide design, the development of efficient technologies allowing rational design of high-affinity peptide ligands for single GPCRs remains an unmet challenge. Here, we
Externí odkaz:
https://doaj.org/article/1f201974b4984c89a23ccc2a9cfd522a
Autor:
Meghan H. Murray, Aurore Cecile Valfort, Thomas Koelblen, Céline Ronin, Fabrice Ciesielski, Arindam Chatterjee, Giri Babu Veerakanellore, Bahaa Elgendy, John K. Walker, Lamees Hegazy, Thomas P. Burris
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The nuclear receptor REV-ERBα is a receptor for heme and plays a role in a range of physiological processes. Here, the authors provide the first structure of REV-ERB bound to a synthetic nonporphyrin ligand defining key mechanistic differences to ho
Externí odkaz:
https://doaj.org/article/e9a3baa7b5fa4017822b58a19fb7301d
Autor:
Sophia Kchouk, Lamees Hegazy
Publikováno v:
Medicine in Drug Discovery, Vol 15, Iss , Pp 100135- (2022)
Many biological targets are characterized by high binding pocket flexibility posing a challenge in identifying important ligand binding features. Liver X receptors (LXRs) are members of the nuclear hormone receptor super family. Although several X-ra
Externí odkaz:
https://doaj.org/article/cb1d78838a1e4d67bee4d6d3a151e2f9
Autor:
Lamees Hegazy, Lauren E. Gill, Kelly D. Pyles, Christopher Kaiho, Sophia Kchouk, Brian N. Finck, Kyle S. McCommis, Bahaa Elgendy
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 365 (2022)
The mitochondrial pyruvate carrier (MPC) is an inner-mitochondrial membrane protein complex that has emerged as a drug target for treating a variety of human conditions. A heterodimer of two proteins, MPC1 and MPC2, comprises the functional MPC compl
Externí odkaz:
https://doaj.org/article/a66280e760704a9eb41b66b1865dfb89
Autor:
Wessam Saaed, Mohamed Elagawany, Mohamed M. Azab, Alaa S. Amin, Nigam P. Rath, Lamees Hegazy, Bahaa Elgendy
Publikováno v:
Results in Chemistry, Vol 2, Iss , Pp 100042- (2020)
We have developed a solvent- and catalyst-free cyclization reaction for the synthesis of 1-arylidenamino-2,4-disubstituted-2-imidazoline-5-ones under neat conditions. The new synthetic procedure is efficient and green in nature. All synthesized compo
Externí odkaz:
https://doaj.org/article/cc4bc5b9ad8a4bdf877504ab743abb69
Autor:
Cyrielle Billon, Sadichha Sitaula, Subhashis Banerjee, Ryan Welch, Bahaa Elgendy, Lamees Hegazy, Tae Gyu Oh, Melissa Kazantzis, Arindam Chatterjee, John Chrivia, Matthew E. Hayes, Weiyi Xu, Angelica Hamilton, Janice M. Huss, Lilei Zhang, John K. Walker, Michael Downes, Ronald M. Evans, Thomas P. Burris
Publikováno v:
ACS Chemical Biology. 18:756-771
Autor:
Weiyi Xu, Andrea Graves, Monika Weisz-Hubshman, Lamees Hegazy, Christina Magyar, Zian Liu, Eleni Nasiotis, Md Abul Hassan Samee, Thomas Burris, Seema Lalani, Lilei Zhang
Publikováno v:
Human Molecular Genetics. 32:959-970
Haploinsufficiency of TGF-beta-activated kinase 1 (MAP3K7) binding protein 2 (TAB2) has been associated with congenital heart disease and more recently multiorgan structural abnormalities. Missense variant represents a major proportion of non-synonym
Autor:
Majed Bawzeer, Mohammed Yaseen, Lamees Hegazy, Bahaa El-Dien M. El-Gendy, Mohamed Elagawany, Mohamed Azab, Magy Gouda, Mostafa E. Rateb
Publikováno v:
Current Pharmaceutical Design. 28:198-207
Background: Spirooxindoles are privileged scaffolds in medicinal chemistry, which were identified through Wang’s pioneering work as inhibitors of MDM2-p53 interactions. Objective: To design and synthesize 2,6-diarylidenecyclohexanones and dispiro[o
Publikováno v:
Journal of Medicinal Chemistry. 64:17545-17571
Farnesoid X receptor (FXR) is an important regulator of bile acid, lipid, amino acid, and glucose homeostasis, hepatic inflammation, regeneration, and fibrosis. FXR has been recognized as a promising drug target for various metabolic diseases such as