Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Lambros J. Tassoulas"'
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108900- (2024)
Summary: Metformin is the first-line treatment for type 2 diabetes, yet its mechanism of action is not fully understood. Recent studies suggest metformin’s interactions with gut microbiota are responsible for exerting therapeutic effects. In this s
Externí odkaz:
https://doaj.org/article/e837cc28bcdc4b61b04c302315839103
Autor:
Betsy M. Martinez-Vaz, Anthony G. Dodge, Rachael M. Lucero, Randy B. Stockbridge, Ashley A. Robinson, Lambros J. Tassoulas, Lawrence P. Wackett
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Metformin is used globally to treat type II diabetes, has demonstrated anti-ageing and COVID mitigation effects and is a major anthropogenic pollutant to be bioremediated by wastewater treatment plants (WWTPs). Metformin is not adsorbed well by activ
Externí odkaz:
https://doaj.org/article/08c30f104ea544edbdd067c7cd19b32b
Autor:
Megan D. Smith, Lambros J. Tassoulas, Troy A. Biernath, Jack E. Richman, Kelly G. Aukema, Lawrence P. Wackett
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3087-3096 (2021)
The OleA enzyme is distinct amongst thiolase enzymes in binding two long (≥C8) acyl chains into structurally-opposed hydrophobic channels, denoted A and B, to carry out a non-decarboxylative Claisen condensation reaction and initiate the biosynthes
Externí odkaz:
https://doaj.org/article/cc59355c65704fb1ad858e57870f7987
Publikováno v:
Environmental Microbiology. 24:5202-5216
The present study examined the regulatory and metabolic response of the aromatic degrader Pseudomonas putida F1 and its tod operon, controlling toluene degradation, to fluorinated aromatic and aliphatic compounds. The tod operon is upregulated by ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59705c1327977cf7e89b81f35c8cab8
https://doi.org/10.1111/1462-2920.16187
https://doi.org/10.1111/1462-2920.16187
Autor:
Jack E. Richman, Lawrence P. Wackett, Kelly G. Aukema, Megan D. Smith, Lambros J. Tassoulas, Troy A. Biernath
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3087-3096 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract The thiolase enzyme OleA initiates the biosynthesis of β-lactone natural products and membrane hydrocarbons via acyl-Coenzyme A (CoA) substrates, but this study showed that p-nitrophenyl alkanoates can substitute, yielding new ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6881f359266ae9a56527a999b9b1406f
http://www.sciencedirect.com/science/article/pii/S2001037021002129
http://www.sciencedirect.com/science/article/pii/S2001037021002129
Autor:
Nicholas Schneider, Danyun Zeng, Lawrence P. Wackett, Nicholas J. Reiter, Amanda Laseke, Lambros J. Tassoulas, Martin St. Maurice
Publikováno v:
Biochemistry
Free guanidine is increasingly recognized as a relevant molecule in biological systems. Recently, it was reported that urea carboxylase acts preferentially on guanidine and, consequently, it was considered to participate directly in guanidine biodegr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422c3d3c89092a7ce27e29809bdbeb61
https://doi.org/10.1021/acs.biochem.0c00537
https://doi.org/10.1021/acs.biochem.0c00537
Filling in the Gaps in Metformin Biodegradation: a New Enzyme and a Metabolic Pathway for Guanylurea
Autor:
Betsy M. Martinez-Vaz, Lawrence P. Wackett, Kelly G. Aukema, Lambros J. Tassoulas, Ashley Robinson
Publikováno v:
Applied and Environmental Microbiology
Metformin is a pharmaceutical most prescribed for type 2 diabetes and is now being examined for potential benefits to COVID-19 patients. People taking the drug pass it largely unchanged, and it subsequently enters wastewater treatment plants.
Th
Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f690bface7569459ccf890cd3a0d9a08
http://europepmc.org/articles/PMC8208167
http://europepmc.org/articles/PMC8208167
Autor:
Nicholas Schneider, Lambros J. Tassoulas, Danyun Zeng, Lawrence P. Wackett, Martin St. Maurice, Nicholas J. Reiter, Amanda Laseke
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e6ae75834c7ec9f03515d8d2f2bed4f
https://doi.org/10.1096/fasebj.2021.35.s1.05379
https://doi.org/10.1096/fasebj.2021.35.s1.05379
Autor:
Lawrence P. Wackett, Lambros J. Tassoulas, Anthony G. Dodge, Serina L. Robinson, Jonathan P. Badalamenti
Publikováno v:
Environmental Microbiology. 20:2099-2111
Biuret is a minor component of urea fertilizer and an intermediate in s-triazine herbicide biodegradation. The microbial metabolism of biuret has never been comprehensively studied. Here, we enriched and isolated bacteria from a potato field that gre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad64372b0a05d7d99e9853e94c00651
https://doi.org/10.1111/1462-2920.14094
https://doi.org/10.1111/1462-2920.14094
Autor:
Madison D. Bygd, Lambros J. Tassoulas, Serina L. Robinson, Jessica F. Konopatski, Kelly G. Aukema, Lawrence P. Wackett
Publikováno v:
Appl Environ Microbiol
Cyanuric acid is an industrial chemical produced during the biodegradation of s-triazine pesticides. The biodegradation of cyanuric acid has been elucidated using a single model system, Pseudomonas sp. strain ADP, in which cyanuric acid hydrolase (At
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00112b0e0d0657b8774a8736a81cdc7
https://pubmed.ncbi.nlm.nih.gov/31676480
https://pubmed.ncbi.nlm.nih.gov/31676480