Ryanodine receptor leak triggers fiber Ca²⁺ redistribution to preserve force and elevate basal metabolism in skeletal muscle

Autor: Lamboley, CR, Pearce, L, Seng, C, Meizoso-Huesca, A, Singh, DP, Frankish, BP, Kaura, V, Lo, HP, Ferguson, C, Allen, PD, Hopkins, PM, Parton, RG, Murphy, RM, van der Poel, C, Barclay, CJ, Launikonis, BS

Muscle contraction depends on tightly regulated Ca2+ release. Aberrant Ca2+ leak through ryanodine receptor 1 (RyR1) on the sarcoplasmic reticulum (SR) membrane can lead to heatstroke and malignant hyperthermia (MH) susceptibility, as well as severe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::bd71f794da65da938b5a6dfbae9e9b85
https://eprints.whiterose.ac.uk/179811/1/sciadv.abi7166.pdf

Evolutionary isolation of ryanodine receptor isoform 1 for muscle-based thermogenesis in mammals.

Autor: Singh DP; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia., Pearce L; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia., Choi RH; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia., Meizoso-Huesca A; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia., Wette SG; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, VIC 3083, Australia., Scott JW; Drug Discovery Biology Unit, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC 3052, Australia.; The Florey Institute of Neuroscience and Mental Health, Melbourne, VIC 3052, Australia., Lamboley CR; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia., Murphy RM; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, VIC 3083, Australia., Launikonis BS; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jan 24; Vol. 120 (4), pp. e2117503120. Date of Electronic Publication: 2023 Jan 17.

Ryanodine receptor leak triggers fiber Ca ²⁺ redistribution to preserve force and elevate basal metabolism in skeletal muscle.

Autor: Lamboley CR; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia., Pearce L; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia., Seng C; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia., Meizoso-Huesca A; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia., Singh DP; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia., Frankish BP; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia., Kaura V; Leeds Institute of Medical Research, University of Leeds, Leeds, UK., Lo HP; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Ferguson C; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia., Allen PD; Leeds Institute of Medical Research, University of Leeds, Leeds, UK., Hopkins PM; Leeds Institute of Medical Research, University of Leeds, Leeds, UK., Parton RG; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.; Centre for Microscopy and Microanalysis, The University of Queensland, Brisbane, QLD, Australia., Murphy RM; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.; Department of Physiology Anatomy and Microbiology, La Trobe University, Melbourne, VIC 3086, Australia., van der Poel C; Department of Physiology Anatomy and Microbiology, La Trobe University, Melbourne, VIC 3086, Australia., Barclay CJ; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia., Launikonis BS; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.

Publikováno v: Science advances [Sci Adv] 2021 Oct 29; Vol. 7 (44), pp. eabi7166. Date of Electronic Publication: 2021 Oct 27.

Effects of high-intensity intermittent exercise on the contractile properties of human type I and type II skeletal muscle fibers.

Autor: Lamboley CR; Institute for Health and Sport, Victoria University, Melbourne, Victoria, Australia.; School of Life Sciences, La Trobe University, Melbourne, Victoria, Australia., Rouffet DM; Institute for Health and Sport, Victoria University, Melbourne, Victoria, Australia.; Department of Health and Sport Sciences, Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, Kentucky., Dutka TL; School of Life Sciences, La Trobe University, Melbourne, Victoria, Australia., McKenna MJ; Institute for Health and Sport, Victoria University, Melbourne, Victoria, Australia., Lamb GD; School of Life Sciences, La Trobe University, Melbourne, Victoria, Australia.

Publikováno v: Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 2020 May 01; Vol. 128 (5), pp. 1207-1216. Date of Electronic Publication: 2020 Mar 26.

Effect of androgen deprivation therapy on the contractile properties of type I and type II skeletal muscle fibres in men with non-metastatic prostate cancer.

Autor: Lamboley CR; Institute of Sport, Exercise and Active Living (ISEAL), College of Sport and Exercise Science, Victoria University, Melbourne, Vic., Australia.; School of Life Sciences, La Trobe University, Melbourne, Vic., Australia., Xu H; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Vic., Australia., Dutka TL; School of Life Sciences, La Trobe University, Melbourne, Vic., Australia., Hanson ED; Institute of Sport, Exercise and Active Living (ISEAL), College of Sport and Exercise Science, Victoria University, Melbourne, Vic., Australia.; Australian Institute for Musculoskeletal Science (AIMSS), Sunshine Hospital, Western Health, Melbourne, Vic., Australia.; College of Health and Biomedicine, Victoria University, Melbourne, Vic., Australia., Hayes A; Institute of Sport, Exercise and Active Living (ISEAL), College of Sport and Exercise Science, Victoria University, Melbourne, Vic., Australia.; Australian Institute for Musculoskeletal Science (AIMSS), Sunshine Hospital, Western Health, Melbourne, Vic., Australia.; College of Health and Biomedicine, Victoria University, Melbourne, Vic., Australia., Violet JA; Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne, Vic., Australia., Murphy RM; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Vic., Australia., Lamb GD; School of Life Sciences, La Trobe University, Melbourne, Vic., Australia.

Publikováno v: Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2018 Feb; Vol. 45 (2), pp. 146-154. Date of Electronic Publication: 2017 Nov 28.