Výsledky vyhledávání - "Lambertus H J Aarts"

Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor

Autor: Judith Gits, Mahban Irandoust, Ivo P. Touw, Onno Roovers, Lambertus H J Aarts, Stefan J. Erkeland

Publikováno v: EMBO Journal, 26(7), 1782-1793. Wiley-Blackwell

The hematopoietic system provides an attractive model for studying growth factor-controlled expansion and differentiation of cells in relation to receptor routing and its consequences for signal transduction. Suppressor of cytokine signaling (SOCS) p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b1142050c28d9090f4e4d06c811791
https://doi.org/10.1038/sj.emboj.7601640

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Viral insertion in Evi12 causes expression of aberrant Grp94 mRNAs containing the viral gag myristylation motif

Autor: Lambertus H J Aarts, Ruud Delwel, Eric van den Akker

Publikováno v: Virology, 366(2), 227-233. Academic Press

Ecotropic Virus Integration site 12 (Evi12) is a common virus insertion site (cVIS) in retrovirally induced murine models of leukemia and lymphoma, suggesting an important role for this locus in these hematopoietic disorders. Evi12 is located near th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9831575719484a7da3a2b8c6112470
https://pubmed.ncbi.nlm.nih.gov/17543366

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Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling

Autor: Lambertus H J Aarts, Judith Gits, Onno Roovers, Sven Eyckerman, Mahban Irandoust, Stefan J. Erkeland, A Klomp, Jan Tavernier, Marijke Valkhof, Ivo P. Touw

Publikováno v: Oncogene. 26(14)

Signals induced by granulocyte colony-stimulating factor (G-CSF), the major cytokine involved in neutrophil development, are tightly controlled by ligand-induced receptor internalization. Truncated G-CSF receptors (G-CSF-Rs) that fail to internalize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cdbb9cbe417e7a5ae79131f0f790a72
https://pubmed.ncbi.nlm.nih.gov/17001306

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G-CSF receptor truncations found in SCN/AML relieve SOCS3-controlled inhibition of STAT5 but leave suppression of STAT3 intact

Autor: Gert-Jan M. van de Geijn, Lambertus H. J. Aarts, Ivo P. Touw, Claudia Heijmans-Antonissen, Judith Gits

Publikováno v: Blood, 104, 667-674. American Society of Hematology

Truncated granulocyte colony-stimulating factor receptors (G-CSF-Rs) are implicated in severe congenital neutropenia (SCN) and the consecutive development of acute myeloid leukemia (AML). Mice expressing G-CSF-R truncation mutants (gcsfr-d715) show d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65e1c755106f05e3da09933325c928d
https://pure.eur.nl/en/publications/f25a2720-02c6-4c50-86bb-28242eb0b156

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G-CSF Receptor Lysine Residues Are Involved in Lysosomal Degradation and Attenuation of G-CSF Signaling Via Distinct Effector Mechanisms

Autor: Onno Roovers, Ivo P. Touw, Marijke Valkhof, Lambertus H J Aarts, Mahban Irandoust, Stefan J. Erkeland

Publikováno v: Blood. 106:3155-3155

The granulocyte colony-stimulating factor receptor (G-CSF-R) induces proliferation, survival and differentiation of myeloid progenitor cells in a tightly controlled temporal fashion. These responses depend on multiple signaling mechanisms that are ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10395fb02d28a00d606093ecdc82c238
https://doi.org/10.1182/blood.v106.11.3155.3155

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