Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lambert P J W van den Heuvel"'
Autor:
Wouter J. C. Feitz, Romy Bouwmeester, Thea J. A. M. van der Velden, Susan Goorden, Christoph Licht, Lambert P. J. W. van den Heuvel, Nicole C. A. J. van de Kar
Publikováno v:
Microorganisms, Vol 9, Iss 10, p 2157 (2021)
In 90% of the cases, childhood hemolytic uremic syndrome (HUS) is caused by an infection with the Shiga toxin (Stx) producing E. coli bacteria (STEC-HUS). Stx preferentially binds to its receptor, the glycosphingolipid, globotriaosylceramide (Gb3), p
Externí odkaz:
https://doaj.org/article/494af96ddb7a437ba2b31e387ac46ae3
Autor:
Wouter J. C. Feitz, Petra A. van Setten, Thea J. A. M. van der Velden, Christoph Licht, Lambert P. J. W. van den Heuvel, Nicole C. A. J. van de Kar
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5615 (2021)
Hemolytic uremic syndrome (HUS) is characterized by a triad of symptoms consisting of hemolytic anemia, thrombocytopenia and acute renal failure. The most common form of HUS is caused by an infection with Shiga toxin (Stx) producing Escherichia coli
Externí odkaz:
https://doaj.org/article/6a0ba2f89edc48ab99ac87ea49291c9b
Autor:
Wouter J. C. Feitz, Nicole C. A. J. van de Kar, Ian Cheong, Thea J. A. M. van der Velden, Carolina G. Ortiz-Sandoval, Dorothea Orth-Höller, Lambert P. J. W. van den Heuvel, Christoph Licht
Publikováno v:
Toxins, Vol 12, Iss 8, p 483 (2020)
Hemolytic uremic syndrome (HUS) is a rare disease primarily characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Endothelial damage is the hallmark of the pathogenesis of HUS with an infection with the Shiga toxin (Stx) produ
Externí odkaz:
https://doaj.org/article/5eb0a7aba7d740c988b3f38747293aad
Autor:
Sarah de Jong, Carel B. Hoyng, Lambert P J W van den Heuvel, Anita de Breuk, Elena B. Volokhina, Yara T. E. Lechanteur, Alejandro Garanto, Sascha Fauser, Suresh Katti, Bjorn Bakker, Anneke I. den Hollander
Publikováno v:
Human Molecular Genetics, 31, 455-70
Human Molecular Genetics, 31, 3, pp. 455-70
Human Molecular Genetics, 31, 3, pp. 455-70
Age-related macular degeneration (AMD) is a major cause of vision loss among the elderly in the Western world. Genetic variants in the complement factor H (CFH) gene are associated with AMD, but the functional consequences of many of these variants a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f32a9ecf69385e49c5e9c94afcf04f0
http://hdl.handle.net/2066/248812
http://hdl.handle.net/2066/248812
Autor:
Christoph Licht, Dorothea Orth-Höller, Wouter J C Feitz, Nicole C. A. J. van de Kar, Lambert P J W van den Heuvel
Publikováno v:
Medizinische Genetik
Atypical hemolytic uremic syndrome (aHUS) is a disorder characterized by thrombocytopenia and microangiopathic hemolytic anemia due to endothelial injury. aHUS is felt to be caused by defective complement regulation due to underlying genetic mutation
Autor:
Anita de Breuk, Sarah de Jong, Lambert P J W van den Heuvel, Yara T. E. Lechanteur, Anneke I. den Hollander, Giuliana Gagliardi, Suresh Katti, Alejandro Garanto, Elena B. Volokhina
Publikováno v:
Progress in Retinal and Eye Research, 84
Contains fulltext : 237835.pdf (Publisher’s version ) (Open Access) Age-related macular degeneration (AMD) is the main cause of vision loss among the elderly in the Western world. While AMD is a multifactorial disease, the complement system was ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f9d6315a94c3fde9720e41de5bac6d
Autor:
Nicole C. A. J. van de Kar, Lambert P J W van den Heuvel, Christoph Licht, Thea J A M van der Velden, Wouter J C Feitz, Petra van Setten
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5615, p 5615 (2021)
International Journal of Molecular Sciences, 22
International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences, 22, 11
International Journal of Molecular Sciences, 22
International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences, 22, 11
Hemolytic uremic syndrome (HUS) is characterized by a triad of symptoms consisting of hemolytic anemia, thrombocytopenia and acute renal failure. The most common form of HUS is caused by an infection with Shiga toxin (Stx) producing Escherichia coli
Autor:
Sascha Fauser, Chiara Suffritti, Federico Martinón-Torres, Esther Willems, Alain J. van Gool, Jeroen D. Langereis, Ronald de Groot, Jenneke J. Keizer-Garritsen, Jolein Gloerich, Laura Lorés-Motta, Renate G. van der Molen, Andrea Zanichelli, Lambert P J W van den Heuvel, Marien I. de Jonge, Anita de Breuk, Michael Levin, Michiel van der Flier, Joris van Drongelen, Elena B. Volokhina, Anneke I. den Hollander, Carel B. Hoyng, Nicole C. A. J. van de Kar, Hans J. C. T. Wessels, Jethro Herberg
Publikováno v:
Clinical & Translational Immunology, 9, 12
Clinical & Translational Immunology, 9
Clinical & Translational Immunology, Vol 9, Iss 12, Pp n/a-n/a (2020)
Clinical & Translational Immunology
Clinical & Translational Immunology, 9
Clinical & Translational Immunology, Vol 9, Iss 12, Pp n/a-n/a (2020)
Clinical & Translational Immunology
Objectives Complement deficiencies are difficult to diagnose because of the variability of symptoms and the complexity of the diagnostic process. Here, we applied a novel ‘complementomics’ approach to study the impact of various complement defici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45d46d131bec8cccd06eadc91ca7536
https://hdl.handle.net/2066/229301
https://hdl.handle.net/2066/229301
Autor:
Victoria J. Wright, Ronald de Groot, Navin P. Boeddha, Marien I. de Jonge, Marieke Emonts, Lambert P J W van den Heuvel, Jenneke J. Keizer-Garritsen, Anouk Suppers, Irene Rivero-Calle, Elena B. Volokhina, Esther Willems, Michael Levin, Ria Philipsen, Alain J. van Gool, Renate G. van der Molen, Hans J. C. T. Wessels, Gerben Ferwerda, Wynand Alkema, Jethro Herberg, Inge M. L. Ahout, Federico Martinon Torres, Jolein Gloerich, Michiel van der Flier
Publikováno v:
Ebiomedicine, 45, 303-313
EBioMedicine
EBioMedicine, 45, 303. Elsevier BV
EBioMedicine, 45, 303-313. Elsevier
Ebiomedicine, 45, pp. 303-313
EBioMedicine
EBioMedicine, 45, 303. Elsevier BV
EBioMedicine, 45, 303-313. Elsevier
Ebiomedicine, 45, pp. 303-313
Background The complement system is a central component of the innate immune system. Constitutive biosynthesis of complement proteins is essential for homeostasis. Dysregulation as a consequence of genetic or environmental cues can lead to inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f5146c96aea8518818fa71c9d9e2a9
http://hdl.handle.net/2066/206044
http://hdl.handle.net/2066/206044