Electrochemistry of potentially bioreductive alkylating quinones. Part 4. Qualitative and quantitative structure-activity relationships of aziridinylquinones

Autor: David N. Reinhoudt, Willem Verboom, S.J. Postma Kelder, R.J. Driebergen, Jos H. Beijnen, Lambert H.M. Janssen, J.J.M. Holthuis, Ed E. Moret, P. Lelieveld

Publikováno v: Recueil des Travaux Chimiques des Pays-Bas. 112:174-185

The concept of bioreductive alkylation as a mechanism of action of aziridinylquinoid anticancer agents has been investigated. The influence of quinone substituents on quinone reduction, on protonation of the aziridines prior to and following quinone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::819fd742c1a3f17dedc9fa9319475c02
https://doi.org/10.1002/recl.19931120216

Effects of oxatomide and derivatives on high affinity IgE receptor-activated signal transduction pathways in rat basophilic leukemia cells: role of protein tyrosine hyperphosphorylation and inhibition of extracellular calcium influx

Autor: Jeannette J.C. Paulussen, Lambert H.M. Janssen, Marcel J.E. Fischer, N. J. de Mol, V. C. Van Der Heijden, R. L. Roozendaal, P. Van Dijken

Publikováno v: Biochemical Pharmacology. 56:693-701

The antiallergic drug oxatomide and analogs inhibit mediator release from a rat basophilic leukemia (RBL-2H3) cell line, which is frequently used as a mast cell model. By investigating a series of derivatives of oxatomide with different inhibiting ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e236bd19290240e634688c656a8dd92
https://doi.org/10.1016/s0006-2952(98)00038-0

Structure–activity relationships of astemizole derivatives for inhibition of store operated Ca2+ channels and exocytosis

Autor: Marcel J.E. Fischer, Jan P. Tollenaere, Jeannette J.C. Paulussen, Nico J. de Mol, Lambert H.M. Janssen

Publikováno v: European Journal of Pharmacology. 350:353-361

The effects of a series of analogues of the antiallergic drug astemizole on the exocytosis of the enzyme beta-hexosaminidase were studied in a mast cell model, the rat basophilic leukemia (RBL-2H3) cell. Besides differences in the effects on Fc epsil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7cd18fcaa9b657b03cfcb833286243
https://doi.org/10.1016/s0014-2999(98)00270-2

Reduction of antitumour mitosenes in non-aqueous and aqueous environment. An electron spin resonance and cyclic voltammetry study

Autor: Lambert H.M. Janssen, Willem Verboom, A.R. Goeptar, Nico P. E. Vermeulen, David N. Reinhoudt, Nico J. de Mol, Marc Maliepaard, Johan M. te Koppele

Publikováno v: Vrije Universiteit Amsterdam
Maliepaard, M, de Mol, N J, Janssen, L H M, Goeptar, A R, te Koppele, J M, Vermeulen, N P E, Verboom, W & Reinhoudt, D N 1995, ' Reduction of antitumour mitosenes in non-aqueous and aqueous environment. An electron spin resonance and cyclic voltammetry study. ', Free Radical Research, vol. 22, pp. 109-121 . https://doi.org/10.3109/10715769509147533
Free Radical Research, 22(2), 109-21. Informa Healthcare
Maliepaard, M, de Mol, N J, Janssen, H L, Goeptar, A R, te Koppele, J M, Vermeulen, N P, Verboom, W & Reinhoudt, D N 1995, ' Reduction of antitumour mitosenes in non-aqueous and aqueous environment. An electron spin resonance and cyclic voltammetry study ', Free Radical Research, vol. 22, no. 2, pp. 109-21 . https://doi.org/10.3109/10715769509147533
Free radical research, 22(22), 109-121. Informa Healthcare
Free Radical Research, 22, 109-121. Informa Healthcare

Chemical reduction of mitosenes under aerobic conditions in DMSO showed characteristic ESR signals of the mitosene derived semiquinone free radicals. However, these signals diminished strongly upon addition of water to the reaction mixture, indicatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696740519acdba85aa816fa6b87f2e0b
https://doi.org/10.3109/10715769509147533

Potential antitumour mitosenes: relationship between in vitro DNA interstrand cross-link formation and DNA damage in escherichia coli K-12 strains

Autor: Lambert H.M. Janssen, Willem Verboom, Karin A.M.C. Sitters, Marc Maliepaard, Nico J. de Mol, Stephens Ma, David N. Reinhoudt, Ian J. Stratford

Publikováno v: Biochemical pharmacology, 48(48), 9320-9323. Elsevier

This investigation was aimed at determining the possible relationship between DNA interstrand cross-linking and the cytotoxic activity of potential antitumour mitosene compounds. Mitosenes, possessing two good leaving groups at C-1 and C-10, were fou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1573e7bc19ab7f0de7e16c1b461e022
https://doi.org/10.1016/0006-2952(94)90559-2