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Permissive Fatty Acid Incorporation Promotes Staphylococcal Adaptation to FASII Antibiotics in Host Environments

Autor: Kénanian, Gérald, Morvan, Claire, Weckel, Antonin, Pathania, Amit, Anba-Mondoloni, Jamila, Halpern, David, Gaillard, Marine, Solgadi, Audrey, Dupont, Laetitia, Henry, Céline, Poyart, Claire, Fouet, Agnès, Lamberet, Gilles, Gloux, Karine, Gruss, Alexandra

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2019, 29 (12), pp.3974-3982.e4. ⟨10.1016/j.celrep.2019.11.071⟩
Cell Reports, Vol 29, Iss 12, Pp 3974-3982.e4 (2019)
Cell Reports, Elsevier Inc, 2019, 29, pp.3974-3982.e4. ⟨10.1016/j.celrep.2019.11.071⟩
Cell Reports, 2019, 29 (12), pp.3974-3982.e4. ⟨10.1016/j.celrep.2019.11.071⟩

Summary: The essentiality of fatty acid synthesis (FASII) products in the human pathogen Staphylococcus aureus is the underlying rationale for FASII-targeted antimicrobial drug design. Reports of anti-FASII efficacy in animals support this choice. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5e0cafc3aaf70afa0daf3208da42c467
https://hal.archives-ouvertes.fr/hal-02421764

Clinical relevance of FASII bypass in Staphylococcus aureus

Autor: Gloux, Karine, Guillemet, Mélanie, Soler, Charles, Morvan, Claire, Halpern, David, Pourcel, Christine, Vu Thien, Hoang, Lamberet, Gilles, Gruss, Alexandra

Publikováno v: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2017, 61 (5), ⟨10.1128/AAC.02515-16⟩
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2017, ⟨10.1128/AAC.02515-16⟩

The need for new antimicrobials to treat bacterial infections has led to the use of fatty acid synthesis (FASII) enzymes as front-line targets. However, recent studies suggest that FASII inhibitors may not work against the opportunist pathogen Staphy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3b99f78912cb880bef7d10df00bd15fd
https://hal.archives-ouvertes.fr/hal-02195054

A partial metabolic pathway enables group b streptococcus to overcome quinone deficiency in a host bacterial community

Autor: Franza, Thierry, Delavenne, Emilie, Derre-Bobillot, Aurelie, Juillard, Vincent, Boulay, Mylène, Demey, Emmanuelle, Vinh, Joelle, Lamberet, Gilles, Gaudu, Philippe

Publikováno v: Molecular Microbiology
Molecular Microbiology, Wiley, 2016, 102 (1), pp.81-91. ⟨10.1111/mmi.13447⟩
Molecular Microbiology, Wiley, 2016, ⟨10.1111/mmi.13447⟩

International audience; Aerobic respiration metabolism in Group B Streptococcus (GBS) is activated by exogenous heme and menaquinone. This capacity enhances resistance of GBS to acid and oxidative stress and improves its survival. In this work, we di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7dd33652c99a5c3d44fa57c57f51591b
https://hal.archives-ouvertes.fr/hal-01412645

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