Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Lama A. Youssef"'
Publikováno v:
BMC Psychiatry, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Chronic treatment-resistant depression (TRD) poses a major challenge for clinicians. Ketamine has shown a rapid but short-lived antidepressant effect in several studies involving TRD patients with different demographic and clinica
Externí odkaz:
https://doaj.org/article/d9ad050a12af4eb6a1277d0db3eb87cf
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Tamoxifen is one of the fundamental pillars of adjuvant endocrine therapy for hormone receptor-positive breast cancer; however, 30–50% of patients receiving tamoxifen experience tumor relapse. CYP2D6, encoded by an extremely pol
Externí odkaz:
https://doaj.org/article/7515b1162bc845188d5f5004b94aab7b
Publikováno v:
Thrombosis Journal, Vol 20, Iss 1, Pp 1-6 (2022)
Abstract Background Warfarin is the most widely used oral anticoagulant; nevertheless, dosing of warfarin is problematic for clinicians worldwide. Inter-individual variability in response to warfarin is attributed to genetic as well as non-genetic fa
Externí odkaz:
https://doaj.org/article/bd9177f717bf47fb816196a8582367a5
Autor:
Alia Alassad, Mhd Jawad Al Rahwanji, Amal Yousfan, Sally Al Moualem, Arwa Farhat, Lama A. Youssef
Publikováno v:
Frontiers in Public Health, Vol 11 (2023)
IntroductionSeroprevalence of transfusion-transmitted viral infections (TTVIs) is a valuable indicator for assessing blood safety, population health and health system performance in the times of peace and conflicts. Only scarce information is availab
Externí odkaz:
https://doaj.org/article/df4df1ae68ab49ffa7c6382511478f97
Autor:
Mousa Alali, Wouroud Ismail Al-khalil, Sara Rijjal, Lana Al-Salhi, Maher Saifo, Lama A. Youssef
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-12 (2022)
Abstract CYP2D6 is a key drug-metabolizing enzyme implicated in the biotransformation of approximately 25% of currently prescribed drugs. Interindividual and interethnic differences in CYP2D6 enzymatic activity, and hence variability in substrate dru
Externí odkaz:
https://doaj.org/article/5acbd829c0bc4bc68ff5b5272f791af6
Autor:
Yara Altawil, Lama A. Youssef
Publikováno v:
Cardiovascular Therapeutics, Vol 2023 (2023)
Background. Vitamin K epoxide reductase complex subunit 1 (VKORC1) gene encodes a key enzyme with multiple cellular activities, namely, the reduction of vitamin K to its active form. VKORC1-1639G>A (rs9923231) is a common single nucleotide polymorphi
Externí odkaz:
https://doaj.org/article/1b659227376e4441a134aa40fea5b2cf
Autor:
Hiba Alarfi, Maher Salamoon, Mohammad Kadri, Moosheer Alammar, Mhd Adel Haykal, Alhadi Alseoudi, Lama A. Youssef
Publikováno v:
BMC Research Notes, Vol 10, Iss 1, Pp 1-7 (2017)
Abstract Objective The prognostic value of body mass index (BMI) in metastatic breast cancer (MBC) has not been fully elucidated. In a prospective study to investigate the chemo-sensitizing effect of statins on clinical outcomes in MBC patients who w
Externí odkaz:
https://doaj.org/article/25a6572035df47ee88d971404cc3dc5b
Publikováno v:
Molecules, Vol 23, Iss 4, p 765 (2018)
Catalysts are employed in many areas of research and development where they combine high efficiency with often astonishing selectivity for their respective substrates. In biology, biocatalysts are omnipresent. Enzymes facilitate highly controlled, so
Externí odkaz:
https://doaj.org/article/9c2f51e673d44e709d36e6c8980ec52f
Autor:
Mousa Alali, Wouroud Ismail Al-khalil, Sara Rijjal, Lana Al-Salhi, Maher Saifo, Lama A. Youssef
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-12 (2022)
Human Genomics
Human Genomics
CYP2D6 is a key drug-metabolizing enzyme implicated in the biotransformation of approximately 25% of currently prescribed drugs. Interindividual and interethnic differences in CYP2D6 enzymatic activity, and hence variability in substrate drug efficac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2fc16909c5289fbb61616d0272fca7
https://pubmed.ncbi.nlm.nih.gov/35123571
https://pubmed.ncbi.nlm.nih.gov/35123571
Preclinical studies support anticancer activity of statins, however, the existing clinical evidence are inconsistent and not definitive. Our study aimed at evaluating a postulated cancer chemo sensitizing effect of statin (simvastatin) in a cohort of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8fd1392427b72132bf0ebf270bc1bb
https://doi.org/10.21203/rs.2.16886/v2
https://doi.org/10.21203/rs.2.16886/v2
