Yersiniabactin, Colibactin and Wider Resistome Contribute to Enhanced Virulence and Persistence of KPC-2-Producing Klebsiella pneumoniae CG258 in South America

Autor: Gabriel Osvaldo Gutkind, Kelly L. Wyres, Fernanda Esposito, Nilton Lincopan, Cunha Mv, Terezinha Knöbl, Rosineide Marques Ribas, Jesús Tamariz, Bruna Fuga Araújo, Gabriela Rodrigues Francisco, Kathryn E. Holt, Ryan R. Wick, Louise Cerdeira, Gerardo González-Rocha, Cifuentes S, Lam Mmc, Bueno Mfc, Doroti de Oliveira Garcia, Louise M. Judd

The emergence and dissemination of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) is a worrisome public health issue compromising the treatment and outcome of infections caused by this pathogen. We performed a detailed virulome an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f97ed739925d3a6acc2c4f0a53032e
https://doi.org/10.1101/435750

Diversity, functional classification and genotyping of SHV β-lactamases in Klebsiella pneumoniae .

Autor: Tsang KK; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK., Lam MMC; Department of Infectious Diseases, School of Translational Medicine, Monash University, Melbourne, Victoria 3004, Australia., Wick RR; Department of Infectious Diseases, School of Translational Medicine, Monash University, Melbourne, Victoria 3004, Australia.; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia., Wyres KL; Department of Infectious Diseases, School of Translational Medicine, Monash University, Melbourne, Victoria 3004, Australia., Bachman M; University of Michigan, Ann Arbor, USA., Baker S; University of Cambridge, Cambridge, UK., Barry K; University of Virginia, Charlottesville, USA., Brisse S; Institut Pasteur, Université Paris Cité, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France., Campino S; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK., Chiaverini A; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise 'G. Caporale', Teramo, Italy., Cirillo DM; Ospedale San Raffaele s.r.l. via olgettina, Milano, Italy., Clark T; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK., Corander J; University of Oslo, Oslo, Norway., Corbella M; Microbiology and Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Cornacchia A; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise 'G. Caporale', Teramo, Italy., Cuénod A; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland., D'Alterio N; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise 'G. Caporale', Teramo, Italy., Di Marco F; Ospedale San Raffaele s.r.l. via olgettina, Milano, Italy., Donado-Godoy P; Centro de Investigación Tibaitatá de AGROSAVIA, Mosquera, Colombia., Egli A; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland., Farzana R; Ineos-Oxford Institute for Antimicrobial Research, Department of Biology, University of Oxford, Oxford, UK., Feil EJ; The Milner Centre for Evolution, Department of Life Sciences, University of Bath, BA2 7AY, Bath, UK., Fostervold A; Department of Medical Microbiology, Stavanger University Hospital, Stavanger, Norway., Gorrie CL; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia., Hassan B; Cardiff University, Cardiff, Wales, UK., Hetland MAK; Department of Medical Microbiology, Stavanger University Hospital, Stavanger, Norway., Hoa LNM; National Hospital for Tropical Diseases, Hanoi, Vietnam., Hoi LT; Hanoi Medical University, Hanoi, Vietnam., Howden B; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia., Ikhimiukor OO; Department of Pharmaceutical Microbiology, University of Ibadan, Ibadan, Nigeria., Jenney AWJ; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia., Kaspersen H; Norwegian Veterinary Institute, Ås, Norway., Khokhar F; University of Cambridge, Cambridge, UK., Leangapichart T; Norwegian Veterinary Institute, Ås, Norway., Ligowska-Marzęta M; Statens Serum Institut, Copenhagen, Denmark., Löhr IH; Department of Medical Microbiology, Stavanger University Hospital, Stavanger, Norway., Long SW; Houston Methodist, Weill Cornell Medical College, New York, USA., Mathers AJ; University of Virginia, Charlottesville, USA., McArthur AG; Michael G. DeGroote Institute for Infectious Disease Research and Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Canada., Nagaraj G; Central Research Laboratory, Kempegowda Institute of Medical Sciences, Bengaluru, India., Oaikhena AO; Department of Pharmaceutical Microbiology, University of Ibadan, Ibadan, Nigeria., Okeke IN; Department of Pharmaceutical Microbiology, University of Ibadan, Ibadan, Nigeria., Perdigão J; University of Lisbon, Lisbon, Portugal., Parikh H; University of Virginia, Charlottesville, USA., Pham MH; Wellcome Sanger Institute, Hinxton, UK., Pomilio F; Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise 'G. Caporale', Teramo, Italy., Raffelsberger N; Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway., Rakotondrasoa A; Institut Pasteur de Bangui, Bangui, Central African Republic., Kumar KLR; Central Research Laboratory, Kempegowda Institute of Medical Sciences, Bengaluru, India., Roberts LW; Queensland University of Technology, Brisbane, Australia., Rodrigues C; Institut Pasteur, Université Paris Cité, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France., Samuelsen Ø; Norwegian National Advisory Unit on Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway.; Department of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway., Sands K; Ineos-Oxford Institute for Antimicrobial Research, Department of Biology, University of Oxford, Oxford, UK., Sassera D; Microbiology and Virology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.; Department of Biology and Biotechnology, University of Pavia, Pavia, Italy., Seth-Smith H; Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland., Shamanna V; Central Research Laboratory, Kempegowda Institute of Medical Sciences, Bengaluru, India., Sherry NL; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia., Sia S; Research Institute for Tropical Medicine, Department of Health, Manila, Philippines., Spadar A; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK., Stoesser N; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Sunde M; Norwegian Veterinary Institute, Ås, Norway., Sundsfjord A; Norwegian National Advisory Unit on Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway.; Department of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway., Thach PN; National Hospital for Tropical Diseases, Hanoi, Vietnam., Thomson NR; Wellcome Sanger Institute, Hinxton, UK., Thorpe HA; University of Oslo, Oslo, Norway., Torok ME; University of Cambridge, Cambridge, UK., Trang VD; National Hospital for Tropical Diseases, Hanoi, Vietnam., Trung NV; Hanoi Medical University, Hanoi, Vietnam., Vornhagen J; Indiana University School of Medicine, Indianapolis, USA., Walsh T; Ineos-Oxford Institute for Antimicrobial Research, Department of Biology, University of Oxford, Oxford, UK., Warne B; University of Cambridge, Cambridge, UK., Wilson H; PHG Foundation, University of Cambridge, Cambridge, UK., Wright GD; Michael G. DeGroote Institute for Infectious Disease Research and Department of Biochemistry & Biomedical Sciences, McMaster University, Hamilton, Canada., Holt KE; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.; Department of Infectious Diseases, School of Translational Medicine, Monash University, Melbourne, Victoria 3004, Australia., KlebNET-Gsp Amr Genotype-Phenotype Group

Publikováno v: Microbial genomics [Microb Genom] 2024 Oct; Vol. 10 (10).

Corrigendum: 'Nanopore-only assemblies for genomic surveillance of the global priority drug-resistant pathogen, Klebsiella pneumoniae '.

Autor: Foster-Nyarko E; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK., Cottingham H; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia., Wick RR; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia., Judd LM; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia., Lam MMC; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia., Wyres KL; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia., Stanton TD; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK., Tsang KK; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK., David S; Centre for Genomic Pathogen Surveillance, Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, Oxford University, Oxford OX3 7LF, UK., Aanensen DM; Centre for Genomic Pathogen Surveillance, Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, Oxford University, Oxford OX3 7LF, UK., Brisse S; Institut Pasteur, Université Paris Cité, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France., Holt KE; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK.; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.

Publikováno v: Microbial genomics [Microb Genom] 2023 Aug; Vol. 9 (8).

Comment on: MDR carbapenemase-producing Klebsiella pneumoniae of the hypervirulence-associated ST23 clone in Poland, 2009-19.

Autor: Lam MMC; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Australia., Holt KE; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Australia.; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK., Wyres KL; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, Australia.

Publikováno v: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2023 Apr 03; Vol. 78 (4), pp. 1132-1134.

Nanopore-only assemblies for genomic surveillance of the global priority drug-resistant pathogen, Klebsiella pneumoniae .

Autor: Foster-Nyarko E; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK., Cottingham H; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia., Wick RR; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia., Judd LM; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia., Lam MMC; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia., Wyres KL; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia., Stanton TD; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK., Tsang KK; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK., David S; Centre for Genomic Pathogen Surveillance, Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, Oxford University, Oxford OX3 7LF, UK., Aanensen DM; Centre for Genomic Pathogen Surveillance, Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, Oxford University, Oxford OX3 7LF, UK., Brisse S; Institut Pasteur, Université Paris Cité, Biodiversity and Epidemiology of Bacterial Pathogens, Paris, France., Holt KE; Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, UK.; Department of Infectious Diseases, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.

Publikováno v: Microbial genomics [Microb Genom] 2023 Feb; Vol. 9 (2).