The vagus nerve mediates the physiological but not pharmacological effects of PYY3-36 on food intake

Autor: Alonso, Aldara Martin, Cork, Simon C., Phuah, Phyllis, Hansen, Benjamin, Norton, Mariana, Cheng, Sijing, Xu, Xiang, Suba, Kinga, Ma, Yue, Dowsett, Georgina KC., Tadross, John A., Lam, Brian YH., Yeo, Giles SH., Herzog, Herbert, Bloom, Stephen R., Arnold, Myrtha, Distaso, Walter, Murphy, Kevin G., Salem, Victoria

Publikováno v: In Molecular Metabolism March 2024 81

Prevalence of deleterious variants in MC3R in patients with constitutional delay of growth and puberty

Autor: Duckett, Katie, Williamson, Alice, Kincaid, John WR, Rainbow, Kara, Corbin, Laura J, Martin, Hilary C, Eberhardt, Ruth Y, Huang, Qin Qin, Hurles, Matthew E, He, Wen, Brauner, Raja, Delaney, Angela, Dunkel, Leo, Grinspon, Romina P, Hall, Janet E, Hirschhorn, Joel N, Howard, Sasha R, Latronico, Ana C, Jorge, Alexander AL, McElreavey, Ken, Mericq, Verónica, Merino, Paulina M, Palmert, Mark R, Plummer, Lacey, Rey, Rodolfo A, Rezende, Raíssa C, Seminara, Stephanie B, Salnikov, Kathryn, Banerjee, Indraneel, Lam, Brian YH, Perry, John RB, Timpson, Nicholas J, Clayton, Peter, Chan, Yee-Ming, Ong, Ken K, O'Rahilly, Stephen

Publikováno v: Duckett, K, Williamson, A, Kincaid, J W R, Rainbow, K, Corbin, L J, Martin, H C, Eberhardt, R Y, Huang, Q Q, Hurles, M E, He, W, Brauner, R, Delaney, A, Dunkel, L, Grinspon, R P, Hall, J E, Hirschhorn, J N, Howard, S R, Latronico, A C, Jorge, A A L, Mcelreavey, K, Mericq, V, Merino, P M, Palmert, M R, Plummer, L, Rey, R A, Rezende, R C, Seminara, S B, Salnikov, K, Banerjee, I, Lam, B Y H, Perry, J R B, Timpson, N J, Clayton, P, Chan, Y-M, Ong, K K & O’rahilly, S 2023, ' Prevalence of deleterious variants in MC3R in patients with constitutional delay of growth and puberty ', The Journal of Clinical Endocrinology & Metabolism . https://doi.org/10.1210/clinem/dgad373

ContextThe melanocortin 3 receptor (MC3R) has recently emerged as a critical regulator of pubertal timing, linear growth and the acquisition of lean mass in humans and mice. In population-based studies, heterozygous carriers of deleterious variants i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afedd926f408e196784190770ba8b48d

Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort

Autor: Wade, Kaitlin H, Lam, Brian YH, Melvin, Audrey, Pan, Warren, Corbin, Laura J, Hughes, David A, Rainbow, Kara, Chen, Jian-Hua, Duckett, Katie, Liu, Xiaoming, Mokrosiński, Jacek, Mörseburg, Alexander, Neaves, Sam, Williamson, Alice, Zhang, Chen, Farooqi, I Sadaf, Yeo, Giles SH, Timpson, Nicholas J, O'Rahilly, Stephen

Mutations in the melanocortin 4 receptor gene (MC4R) are associated with obesity but little is known about the prevalence and impact of such mutations throughout human growth and development. We examined the MC4R coding sequence in 5,724 participants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______109::8df96f1084f3d520e02e580085cda319
https://www.repository.cam.ac.uk/handle/1810/321319

Global transcriptomic analysis of the arcuate nucleus following chronic glucocorticoid treatment

Autor: Wray, Jonathan R, Davies, Alison, Sefton, Charlotte, Allen, Tiffany-Jayne, Adamson, Antony, Chapman, Philip, Lam, Brian YH, Yeo, Giles SH, Coll, Anthony P, Harno, Erika, White, Anne

Publikováno v: Molecular Metabolism
Wray, J, Davies, A, Sefton, C, Allen, T-J, Adamson, A, Chapman, P, Lam, B Y H, Yeo, G S H, Coll, A P, Harno, E & White, A 2019, ' Global Transcriptomic Analysis of the Arcuate Nucleus following Chronic Glucocorticoid Treatment ', Molecular Metabolism, vol. 26, pp. 5-17 . https://doi.org/10.1016/j.molmet.2019.05.008
Molecular Metabolism, Vol 26, Iss, Pp 5-17 (2019)

Objective Glucocorticoids (GCs) are widely prescribed medications that are well recognized to cause adverse metabolic effects including hyperphagia, obesity, and hyperglycemia. These effects have been recapitulated in a murine model of GC excess, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e90c1e8f10bcf1ef631294304e0bc008
http://europepmc.org/articles/PMC6667392

Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity

Autor: Cimino, Irene, Rimmington, Debra, Tung, YC Loraine, Lawler, Katherine, Larraufie, Pierre, Kay, Richard G, Virtue, Samuel, Lam, Brian YH, Fagnocchi, Luca, Ma, Marcella KL, Saudek, Vladimir, Zvetkova, Ilona, Vidal-Puig, Antonio, Yeo, Giles SH, Farooqi, I Sadaf, Pospisilik, J Andrew, Gribble, Fiona M, Reimann, Frank, O'Rahilly, Stephen, Coll, Anthony P

Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype of a bim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d2b3270b3d79a78f668c71c1ac904be