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Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

Autor: Gordon, David E, Hiatt, Joseph, Bouhaddou, Mehdi, Rezelj, Veronica V, Ulferts, Svenja, Braberg, Hannes, Jureka, Alexander S, Obernier, Kirsten, Guo, Jeffrey Z, Batra, Jyoti, Kaake, Robyn M, Weckstein, Andrew R, Owens, Tristan W, Gupta, Meghna, Pourmal, Sergei, Titus, Erron W, Cakir, Merve, Soucheray, Margaret, McGregor, Michael, Cakir, Zeynep, Jang, Gwendolyn, O'Meara, Matthew J, Tummino, Tia A, Zhang, Ziyang, Foussard, Helene, Rojc, Ajda, Zhou, Yuan, Kuchenov, Dmitry, Hüttenhain, Ruth, Xu, Jiewei, Eckhardt, Manon, Swaney, Danielle L, Fabius, Jacqueline M, Ummadi, Manisha, Tutuncuoglu, Beril, Rathore, Ujjwal, Modak, Maya, Haas, Paige, Haas, Kelsey M, Naing, Zun Zar Chi, Pulido, Ernst H, Shi, Ying, Barrio-Hernandez, Inigo, Memon, Danish, Petsalaki, Eirini, Dunham, Alistair, Marrero, Miguel Correa, Burke, David, Koh, Cassandra, Vallet, Thomas, Silvas, Jesus A, Azumaya, Caleigh M, Billesbølle, Christian, Brilot, Axel F, Campbell, Melody G, Diallo, Amy, Dickinson, Miles Sasha, Diwanji, Devan, Herrera, Nadia, Hoppe, Nick, Kratochvil, Huong T, Liu, Yanxin, Merz, Gregory E, Moritz, Michelle, Nguyen, Henry C, Nowotny, Carlos, Puchades, Cristina, Rizo, Alexandrea N, Schulze-Gahmen, Ursula, Smith, Amber M, Sun, Ming, Young, Iris D, Zhao, Jianhua, Asarnow, Daniel, Biel, Justin, Bowen, Alisa, Braxton, Julian R, Chen, Jen, Chio, Cynthia M, Chio, Un Seng, Deshpande, Ishan, Doan, Loan, Faust, Bryan, Flores, Sebastian, Jin, Mingliang, Kim, Kate, Lam, Victor L, Li, Fei, Li, Junrui, Li, Yen-Li, Li, Yang, Liu, Xi, Lo, Megan, Lopez, Kyle E, Melo, Arthur A, Moss, Frank R, Nguyen, Phuong, Paulino, Joana, Pawar, Komal Ishwar, Peters, Jessica K

Publikováno v: Science (New York, N.Y.), vol 370, iss 6521

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7a4b99b00468a717b0831412c2a80ffd
https://escholarship.org/uc/item/46t221r6

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.

Autor: Walter M; Buck Institute for Research on Aging, Novato, CA, United States., Chen IP; Gladstone Institutes, San Francisco, CA, United States.; University of California San Francisco, San Francisco, CA, United States., Vallejo-Gracia A; Gladstone Institutes, San Francisco, CA, United States.; University of California San Francisco, San Francisco, CA, United States., Kim IJ; Buck Institute for Research on Aging, Novato, CA, United States., Bielska O; Buck Institute for Research on Aging, Novato, CA, United States., Lam VL; University of California San Francisco, San Francisco, CA, United States., Hayashi JM; Gladstone Institutes, San Francisco, CA, United States.; University of California San Francisco, San Francisco, CA, United States., Cruz A; Buck Institute for Research on Aging, Novato, CA, United States., Shah S; Buck Institute for Research on Aging, Novato, CA, United States., Gross JD; University of California San Francisco, San Francisco, CA, United States.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, United States., Krogan NJ; Gladstone Institutes, San Francisco, CA, United States.; University of California San Francisco, San Francisco, CA, United States.; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, United States.; QBI COVID-19 Research Group (QCRG), San Francisco, CA, United States., Schilling B; Buck Institute for Research on Aging, Novato, CA, United States., Ott M; Gladstone Institutes, San Francisco, CA, United States.; University of California San Francisco, San Francisco, CA, United States., Verdin E; Buck Institute for Research on Aging, Novato, CA, United States.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2022 Jan 05. Date of Electronic Publication: 2022 Jan 05.

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.

Autor: Gupta M; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Azumaya CM; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Moritz M; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Pourmal S; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Diallo A; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Merz GE; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Jang G; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Bouhaddou M; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Fossati A; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Brilot AF; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Diwanji D; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Hernandez E; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Herrera N; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Kratochvil HT; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Lam VL; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Li F; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Li Y; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Nguyen HC; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Nowotny C; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Owens TW; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Peters JK; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Rizo AN; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Schulze-Gahmen U; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Smith AM; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Young ID; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Yu Z; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Asarnow D; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Billesbølle C; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Campbell MG; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Current affiliation: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Chen J; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Chen KH; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Chio US; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Dickinson MS; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Doan L; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Jin M; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Kim K; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Li J; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Li YL; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Linossi E; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Liu Y; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Lo M; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Lopez J; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Lopez KE; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Mancino A; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Moss FR 3rd; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Paul MD; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Pawar KI; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Pelin A; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Pospiech TH Jr; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Puchades C; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Remesh SG; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Safari M; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Schaefer K; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Sun M; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Current affiliation: Beam Therapeutics, Cambridge, MA 02139, USA., Tabios MC; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Thwin AC; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Titus EW; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Trenker R; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Tse E; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Tsui TKM; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Wang F; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Zhang K; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Zhang Y; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Zhao J; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Zhou F; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA., Zhou Y; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Zuliani-Alvarez L; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Agard DA; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA., Cheng Y; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.; Howard Hughes Medical Institute, San Francisco, CA 94158, USA., Fraser JS; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA., Jura N; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA., Kortemme T; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA.; The University of California, Berkeley-University of California, San Francisco Graduate Program in Bioengineering, University of California, San Francisco, CA 94158, USA., Manglik A; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA., Southworth DR; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA., Stroud RM; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA., Swaney DL; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA., Krogan NJ; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.; J. David Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Frost A; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.; Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA., Rosenberg OS; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.; Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA.; Department of Medicine, University of California, San Francisco, CA 94143, USA., Verba KA; QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA.; Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, CA 94158, USA.; QBI, University of California, San Francisco, CA 94158, USA.; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA.

Publikováno v: Research square [Res Sq] 2021 May 19. Date of Electronic Publication: 2021 May 19.