Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Lam, Alex C."'
Autor:
Lam, Alex C.
Quantitative Trait Loci (QTL) mapping has been widely used to identify genetic loci attributable to the variation observed in complex traits. In recent years, gene expression phenotypes have emerged as a new type of quantitative trait for which QTL c
Externí odkaz:
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.562525
Autor:
Burren Oliver S, Healy Barry C, Lam Alex C, Schuilenburg Helen, Dolman Geoffrey E, Everett Vincent H, Laneri Davide, Nutland Sarah, Rance Helen E, Payne Felicity, Smyth Deborah, Lowe Chris, Barratt Bryan J, Twells Rebecca CJ, Rainbow Daniel B, Wicker Linda S, Todd John A, Walker Neil M, Smink Luc J
Publikováno v:
Human Genomics, Vol 1, Iss 2, Pp 98-109 (2004)
Abstract The genetic dissection of complex disease remains a significant challenge. Sample-tracking and the recording, processing and storage of high-throughput laboratory data with public domain data, require integration of databases, genome informa
Externí odkaz:
https://doaj.org/article/823c52cce9af4db5ab229c0b9b6a76d1
Autor:
Smink Luc J, Walker Neil M, Burren Oliver, Lam Alex C, Healy Barry C, Nutland Sarah, Bailey Rebecca, Smyth Deborah J, Cooper Jason D, Lowe Christopher E, Taniguchi Hidenori, Wicker Linda S, Todd John A
Publikováno v:
BMC Genetics, Vol 7, Iss 1, p 22 (2006)
Abstract Background Type 1 diabetes (T1D) is a common autoimmune disease resulting from T-cell mediated destruction of pancreatic beta cells. Decay accelerating factor (DAF, CD55), a glycosylphosphatidylinositol-anchored membrane protein, is a candid
Externí odkaz:
https://doaj.org/article/7011c124141642e49bf19ba66e134d25
Autor:
Walker Neil M, Nutland Sarah, Lam Alex C, Dahlman Ingrid, Vella Adrian, Hulme John S, Cooper Jason D, Lowe Christopher E, Holland Kieran, Bailey Rebecca, Maier Lisa M, Payne Felicity, Howson Joanna MM, Smyth Deborah J, Twells Rebecca CJ, Todd John A
Publikováno v:
BMC Medical Genetics, Vol 7, Iss 1, p 20 (2006)
Abstract Background The identification of the HLA class II, insulin (INS), CTLA-4 and PTPN22 genes as determinants of type 1 diabetes (T1D) susceptibility indicates that fine tuning of the immune system is centrally involved in disease development. S
Externí odkaz:
https://doaj.org/article/743bca594e3c4923877ac0ba5cce95e6
Autor:
Lam Alex C, Healy Barry C, Walker Neil M, Hulme John S, Godfrey Lisa, Vella Adrian, Payne Felicity, Cooper Jason D, Lowe Christopher E, Morris Gerard AJ, Lyons Paul A, Todd John A
Publikováno v:
BMC Genetics, Vol 7, Iss 1, p 12 (2006)
Abstract Background The aetiology of the autoimmune disease type 1 diabetes (T1D) involves many genetic and environmental factors. Evidence suggests that innate immune responses, including the action of interferons, may also play a role in the initia
Externí odkaz:
https://doaj.org/article/bc4f5202af8c401ebe0bee4c48d8d622
Publikováno v:
In Trends in Microbiology 1 July 2001 9(7):302-307
Publikováno v:
In Trends in Microbiology 2001 9(11):518-521
Publikováno v:
In Trends in Microbiology 2001 9(3):97-101
Autor:
Smink Luc J, Lam Alex C, Smith Anne, Twells Rebecca CJ, Sebastian Meera, Smyth Deborah J, Nutland Sarah, Barratt Bryan J, Rance Helen E, Pask Rebecca, Walker Neil M, Todd John A
Publikováno v:
BMC Biotechnology, Vol 4, Iss 1, p 15 (2004)
Abstract Background Sustainable DNA resources and reliable high-throughput genotyping methods are required for large-scale, long-term genetic association studies. In the genetic dissection of common disease it is now recognised that thousands of samp
Externí odkaz:
https://doaj.org/article/aef12a9d76b845ad98c433c5e1222732