Macromolecular condensation organizes nucleolar sub-phases to set up a pH gradient.

Autor: King MR; Department of Biomedical Engineering, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA; Center for Biomolecular Condensates, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA., Ruff KM; Department of Biomedical Engineering, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA; Center for Biomolecular Condensates, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA., Lin AZ; Department of Biomedical Engineering, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA; Center for Biomolecular Condensates, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA., Pant A; Department of Biomedical Engineering, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA; Center for Biomolecular Condensates, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA., Farag M; Department of Biomedical Engineering, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA; Center for Biomolecular Condensates, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA., Lalmansingh JM; Department of Biomedical Engineering, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA; Center for Biomolecular Condensates, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA., Wu T; Center for Biomolecular Condensates, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA; Department of Electrical and Systems Engineering, James F. McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA., Fossat MJ; Department of Biomedical Engineering, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA; Center for Biomolecular Condensates, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA., Ouyang W; Department of Bioengineering, Schools of Engineering and Medicine, Stanford University, Stanford, CA, USA; Department of Pathology, School of Medicine, Stanford University, Stanford, CA, USA; Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH-Royal Institute of Technology, Stockholm, Sweden., Lew MD; Center for Biomolecular Condensates, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA; Department of Electrical and Systems Engineering, James F. McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA., Lundberg E; Department of Bioengineering, Schools of Engineering and Medicine, Stanford University, Stanford, CA, USA; Department of Pathology, School of Medicine, Stanford University, Stanford, CA, USA; Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH-Royal Institute of Technology, Stockholm, Sweden., Vahey MD; Department of Biomedical Engineering, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA; Center for Biomolecular Condensates, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA., Pappu RV; Department of Biomedical Engineering, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA; Center for Biomolecular Condensates, James McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: pappu@wustl.edu.

Publikováno v: Cell [Cell] 2024 Apr 11; Vol. 187 (8), pp. 1889-1906.e24. Date of Electronic Publication: 2024 Mar 18.

SOURSOP: A Python Package for the Analysis of Simulations of Intrinsically Disordered Proteins.

Autor: Lalmansingh JM; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, United States.; Center for Biomolecular Condensates, Washington University in St. Louis, St. Louis, Missouri 63130, United States., Keeley AT; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, United States.; Department of Chemistry, University of Illinois Urbana-Champaign, Urbana-Champaign, Illinois 61801, United States., Ruff KM; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, United States.; Center for Biomolecular Condensates, Washington University in St. Louis, St. Louis, Missouri 63130, United States., Pappu RV; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, United States.; Center for Biomolecular Condensates, Washington University in St. Louis, St. Louis, Missouri 63130, United States., Holehouse AS; Center for Biomolecular Condensates, Washington University in St. Louis, St. Louis, Missouri 63130, United States.; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110, United States.

Publikováno v: Journal of chemical theory and computation [J Chem Theory Comput] 2023 Aug 22; Vol. 19 (16), pp. 5609-5620. Date of Electronic Publication: 2023 Jul 18.

Mechanistic Inferences From Analysis of Measurements of Protein Phase Transitions in Live Cells.

Autor: Posey AE; Department of Biomedical Engineering and Center for Science & Engineering of Living Systems, Washington University in St. Louis, St. Louis, MO 63130, USA. Electronic address: ammonposey@wustl.edu., Ruff KM; Department of Biomedical Engineering and Center for Science & Engineering of Living Systems, Washington University in St. Louis, St. Louis, MO 63130, USA., Lalmansingh JM; Department of Biomedical Engineering and Center for Science & Engineering of Living Systems, Washington University in St. Louis, St. Louis, MO 63130, USA; Department of Physics, Washington University in St. Louis, St. Louis, MO 63130, USA., Kandola TS; Stowers Institute for Medical Research, Kansas City, MO 64110, USA; The Open University, Milton Keynes MK7 6AA, United Kingdom., Lange JJ; Stowers Institute for Medical Research, Kansas City, MO 64110, USA., Halfmann R; Stowers Institute for Medical Research, Kansas City, MO 64110, USA; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA., Pappu RV; Department of Biomedical Engineering and Center for Science & Engineering of Living Systems, Washington University in St. Louis, St. Louis, MO 63130, USA. Electronic address: pappu@wustl.edu.

Publikováno v: Journal of molecular biology [J Mol Biol] 2021 Jun 11; Vol. 433 (12), pp. 166848. Date of Electronic Publication: 2021 Feb 02.

Biomolecular condensates as stress sensors and modulators of bacterial signaling.

Autor: Sasazawa, Moeka¹ (AUTHOR), Tomares, Dylan T.² (AUTHOR), Childers, W. Seth² (AUTHOR) wschild@pitt.edu, Saurabh, Saumya¹ (AUTHOR) saumya@nyu.edu

Publikováno v: PLoS Pathogens. 8/15/2024, Vol. 20 Issue 8, p1-25. 25p.

Weighted families of contact maps to characterize conformational ensembles of (highly-)flexible proteins.

Autor: González-Delgado, Javier, Bernadó, Pau, Neuvial, Pierre, Cortés, Juan

Publikováno v: Bioinformatics; Nov2024, Vol. 40 Issue 11, p1-10, 10p