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Synthesis and antiviral evaluation of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease.

Autor: Alexandre FR; IDENIX, an MSD Company, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 MONTPELLIER Cedex 4, France. Electronic address: francois-rene.alexandre@merck.com., Brandt G; IDENIX, an MSD Company, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 MONTPELLIER Cedex 4, France., Caillet C; IDENIX, an MSD Company, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 MONTPELLIER Cedex 4, France., Chaves D; IDENIX, an MSD Company, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 MONTPELLIER Cedex 4, France., Convard T; IDENIX, an MSD Company, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 MONTPELLIER Cedex 4, France., Derock M; IDENIX, an MSD Company, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 MONTPELLIER Cedex 4, France., Gloux D; IDENIX, an MSD Company, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 MONTPELLIER Cedex 4, France., Griffon Y; IDENIX, an MSD Company, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 MONTPELLIER Cedex 4, France., Lallos L; IDENIX, an MSD Company, 320 Bent Street-4th Floor, Cambridge, MA 02139, USA., Leroy F; IDENIX, an MSD Company, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 MONTPELLIER Cedex 4, France., Liuzzi M; IDENIX, an MSD Company, 320 Bent Street-4th Floor, Cambridge, MA 02139, USA., Loi AG; IDENIX, an MSD Company, 320 Bent Street-4th Floor, Cambridge, MA 02139, USA., Moulat L; IDENIX, an MSD Company, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 MONTPELLIER Cedex 4, France., Musiu C; IDENIX, an MSD Company, 320 Bent Street-4th Floor, Cambridge, MA 02139, USA., Parsy C; IDENIX, an MSD Company, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 MONTPELLIER Cedex 4, France., Rahali H; IDENIX, an MSD Company, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 MONTPELLIER Cedex 4, France., Roques V; IDENIX, an MSD Company, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 MONTPELLIER Cedex 4, France., Seifer M; IDENIX, an MSD Company, 320 Bent Street-4th Floor, Cambridge, MA 02139, USA., Standring D; IDENIX, an MSD Company, 320 Bent Street-4th Floor, Cambridge, MA 02139, USA., Surleraux D; IDENIX, an MSD Company, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 MONTPELLIER Cedex 4, France.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Sep 15; Vol. 25 (18), pp. 3984-91. Date of Electronic Publication: 2015 Jul 14.

Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease.

Autor: Parsy C; IDENIX Pharmaceuticals, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France. Electronic address: parsy.christophe@idenix.com., Alexandre FR; IDENIX Pharmaceuticals, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France., Brandt G; IDENIX Pharmaceuticals, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France., Caillet C; IDENIX Pharmaceuticals, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France., Cappelle S; IDENIX Pharmaceuticals, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France., Chaves D; IDENIX Pharmaceuticals, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France., Convard T; IDENIX Pharmaceuticals, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France., Derock M; IDENIX Pharmaceuticals, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France., Gloux D; IDENIX Pharmaceuticals, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France., Griffon Y; IDENIX Pharmaceuticals, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France., Lallos L; IDENIX Pharmaceuticals, 320 Bent Street-4th Floor, Cambridge, MA 02139, USA., Leroy F; IDENIX Pharmaceuticals, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France., Liuzzi M; IDENIX Pharmaceuticals, 320 Bent Street-4th Floor, Cambridge, MA 02139, USA., Loi AG; IDENIX Pharmaceuticals, 320 Bent Street-4th Floor, Cambridge, MA 02139, USA., Moulat L; IDENIX Pharmaceuticals, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France., Musiu C; IDENIX Pharmaceuticals, 320 Bent Street-4th Floor, Cambridge, MA 02139, USA., Rahali H; IDENIX Pharmaceuticals, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France., Roques V; IDENIX Pharmaceuticals, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France., Seifer M; IDENIX Pharmaceuticals, 320 Bent Street-4th Floor, Cambridge, MA 02139, USA., Standring D; IDENIX Pharmaceuticals, 320 Bent Street-4th Floor, Cambridge, MA 02139, USA., Surleraux D; IDENIX Pharmaceuticals, 1682 rue de la Valsière, Cap Gamma, BP 50001, 34189 Montpellier Cedex 4, France.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 Sep 15; Vol. 24 (18), pp. 4444-4449. Date of Electronic Publication: 2014 Aug 09.

20 IN VITRO ACTIVITY AND PHARMACOLOGIC PROPERTIES OF TWO NOVEL SERIES OF HCV PROTEASE INHIBITORS

Autor: Standring, D.N., Parsy, C., Alexandre, F.-R., Derock, M., Leroy, F., Convard, T., La Colla, M., Lallos, L., Loi, A.-G., Musiu, C., Marceddu, T., Poddesu, B., Vargiu, L., Liuzzi, M., Surleraux, D.

Publikováno v: In Journal of Hepatology 2008 48 Supplement 2:S10-S10

[427] VALOPICITABINE (NM283) IS FULLY ACTIVE AGAINST KNOWN HCV PROTEASE RESISTANCE MUTATIONS IN VITRO

Autor: Bichko, V., Lallos, L., Soubasakos, M., LaColla, M., Tausek, M.M., Gillum, J., Standring, D.N.

Publikováno v: In Journal of Hepatology 2007 46 Supplement 1:S163-S164