Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lalitha Sastry"'
Autor:
Lorna M MacLean, Mark Ariyanayagam, Lalitha Sastry, Christy Paterson, Manu De Rycker, Alan H Fairlamb
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0300021 (2024)
Trypanosoma cruzi (T. cruzi) is the causative agent of Chagas' disease, a parasitic infection responsible for significant morbidity and mortality in Latin America. The current treatments have many serious drawbacks and new drugs are urgently required
Externí odkaz:
https://doaj.org/article/919309b6fde141f59c00805954a3d78a
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 9, p e0004977 (2016)
Trypanosoma vivax is one of the causative agents of Animal African Trypanosomosis in cattle, which is endemic in sub-Saharan Africa and transmitted primarily by the bite of the tsetse fly vector. The parasite can also be mechanically transmitted, and
Externí odkaz:
https://doaj.org/article/89741c9f4ac748e68e1d3c265d242566
Autor:
Lauren Sullivan, Jennifer Fleming, Lalitha Sastry, Angela Mehlert, Steven J Wall, Michael A J Ferguson
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 7, p e2976 (2014)
The diagnosis of human African trypanosomiasis (HAT) caused by Trypanosoma brucei gambiense relies mainly on the Card Agglutination Test for Trypanosomiasis (CATT). There is no immunodiagnostic for HAT caused by T. b. rhodesiense. Our principle aim w
Externí odkaz:
https://doaj.org/article/8ccf4a307e85480a9278a2e0fe172132
Autor:
Jennifer R Fleming, Lalitha Sastry, Thomas W M Crozier, Grant B Napier, Lauren Sullivan, Michael A J Ferguson
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 6, p e2936 (2014)
Animal African Trypanosomosis (AAT) presents a severe problem for agricultural development in sub-Saharan Africa. It is caused by several trypanosome species and current means of diagnosis are expensive and impractical for field use. Our aim was to d
Externí odkaz:
https://doaj.org/article/a539e9cb54e3463ab164351443978f53
Autor:
Ian H. Gilbert, Sandra Carvalho, Stephen Thompson, Lorna MacLean, Fabio Zuccotto, Susan Wyllie, Timothy J. Miles, Lalitha Sastry, Ignacio Cotillo, Manu De Rycker, Juan A. Bueren-Calabuig, Sonia Moniz, Rachel Milne, Albane Kessler, Maria L. Marco, Julio Martin, Richard J. Wall, Alan H. Fairlamb, Juan Cantizani-Perez, Michael G. Thomas, Stephen Patterson, Sujatha Manthri
Publikováno v:
ACS Infectious Diseases
Available treatments for Chagas' disease and visceral leishmaniasis are inadequate, and there is a pressing need for new therapeutics. Drug discovery efforts for both diseases principally rely upon phenotypic screening. However, the optimization of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbdbdb72ed0d785ae1f89aec7a44bf2
http://europepmc.org/articles/PMC7076694
http://europepmc.org/articles/PMC7076694
Autor:
Filip, Zmuda, Lalitha, Sastry, Sharon M, Shepherd, Deuan, Jones, Alison, Scott, Peter D, Craggs, Alvaro, Cortes, David W, Gray, Leah S, Torrie, Manu, De Rycker
Publikováno v:
Antimicrobial Agents and Chemotherapy
Chagas’ disease, caused by the protozoan parasite Trypanosoma cruzi, is a potentially life-threatening condition that has become a global issue. Current treatment is limited to two medicines that require prolonged dosing and are associated with mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad05f3ce13b5bcab8deb901904fe4ffe
https://pubmed.ncbi.nlm.nih.gov/31307977
https://pubmed.ncbi.nlm.nih.gov/31307977
Autor:
Stephanie Gresham, Stephen Patterson, Laste Stojanovski, Fabio Zuccotto, Susan Wyllie, Matthew Berriman, Timothy J. Miles, Frederick R. C. Simeons, Nadine Homeyer, Lorna MacLean, Paul Connolly, Lalitha Sastry, Manu De Rycker, Rhiannon Lowe, Gerard Drewes, Sabrinia D. Crouch, David W. Gray, Thomas D. Otto, Sebastian Albrecht, Michael G. Thomas, Michael A. J. Ferguson, Sujatha Manthri, Michael D. Urbaniak, Markus Boesche, Hannah Pflaumer, Alan H. Fairlamb, Ian H. Gilbert, Sonja Ghidelli-Disse, Kevin D. Read, Paul G. Wyatt, Jose M. Fiandor, Susan Dixon
Publikováno v:
Nature
Visceral leishmaniasis causes considerable mortality and morbidity in many parts of the world. There is an urgent need for the development of new, effective treatments for this disease. Here we describe the development of an anti-leishmanial drug-lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6f9bff9da702dd0f4d789ce1ce05a4
https://pubmed.ncbi.nlm.nih.gov/30076375
https://pubmed.ncbi.nlm.nih.gov/30076375