Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Lalitha Guruprasad"'
Autor:
Naganjaneyulu Gariganti, Anjaneyulu Bandi, K.R.S. Naresh Gatta, Jishu Pagag, Lalitha Guruprasad, Bhaskar Poola, Ravi K. Kottalanka
Publikováno v:
Heliyon, Vol 10, Iss 9, Pp e30292- (2024)
Cancer is a broad classification of diseases that can affect any organ or body tissue due to aberrant cellular proliferation for unknown reasons. Many present chemotherapeutic drugs are highly toxic and have little selectivity. Additionally, they lea
Externí odkaz:
https://doaj.org/article/902101cdeaaa466ba22bcdedf91a4cee
Publikováno v:
Current Research in Structural Biology, Vol 6, Iss , Pp 100107- (2023)
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causative agent of the coronavirus disease-2019 (COVID-19) has resulted in several deaths and severe economic losses throughout the world. The spike protein in the virus binds to the h
Externí odkaz:
https://doaj.org/article/230ed52bfa1b466b822095e40df36c42
Autor:
Yugo Tsuchiya, Dominic P. Byrne, Selena G. Burgess, Jenny Bormann, Jovana Baković, Yueyang Huang, Alexander Zhyvoloup, Bess Yi Kun Yu, Sew Peak-Chew, Trang Tran, Fiona Bellany, Alethea B. Tabor, AW Edith Chan, Lalitha Guruprasad, Oleg Garifulin, Valeriy Filonenko, Matthias Vonderach, Samantha Ferries, Claire E. Eyers, John Carroll, Mark Skehel, Richard Bayliss, Patrick A. Eyers, Ivan Gout
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
Aurora A kinase is a master mitotic regulator whose functions are controlled by several regulatory interactions and post-translational modifications. It is frequently dysregulated in cancer, making Aurora A inhibition a very attractive antitumor targ
Externí odkaz:
https://doaj.org/article/0b4c8d09c14d4fdebd87d9bb7b34b081
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0146786 (2016)
The PE and PPE protein family are unique to mycobacteria. Though the complete genome sequences for over 500 M. tuberculosis strains and mycobacterial species are available, few PE and PPE proteins have been structurally and functionally characterized
Externí odkaz:
https://doaj.org/article/c993936d493f4fcbaf5222d3e1cf201f
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115020 (2014)
The availability of complete genome sequences of H. pylori 26695 has provided a wealth of information enabling us to carry out in silico studies to identify new molecular targets for pharmaceutical treatment. In order to construe the structural and f
Externí odkaz:
https://doaj.org/article/f1711592e35d4b469bba968818e621f2
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55320 (2013)
The PE and PPE multigene families, first discovered during the sequencing of M. tuberculosis H37Rv genome are responsible for antigenic variation and have been shown to induce increased humoral and cell mediated immune response in the host. Using the
Externí odkaz:
https://doaj.org/article/47c60facf4ca4114a201137427d9921a
Autor:
Karunakar Tanneeru, Lalitha Guruprasad
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78556 (2013)
BCR-ABL kinase domain inhibition can be used to treat chronic myeloid leukemia. The inhibitors such as imatinib, dasatinib and nilotinib are effective drugs but are resistant to some BCR-ABL mutations. The pan-BCR-ABL kinase inhibitor ponatinib exhib
Externí odkaz:
https://doaj.org/article/7e825eaf46ad409cb79847932fca4231
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16745 (2011)
The PE and PPE proteins first reported in the genome sequence of Mycobacterium tuberculosis strain H37Rv are now identified in all mycobacterial species. The PE-PPE domain (Pfam ID: PF08237) is a 225 amino acid residue conserved region located toward
Externí odkaz:
https://doaj.org/article/95d6ff943f064bc2a587cf9103a78b1b
Publikováno v:
Evolutionary Bioinformatics, Vol 2 (2006)
We have identified based on gene cluster analysis that the genes between Rv3799–Rv3807 in M. tuberculosis have orthologs in Corynebacteria, Mycobacteria and Nocardia (CMN) genomes. Therefore, this gene cluster possibly corresponds to the ‘Ancient
Externí odkaz:
https://doaj.org/article/463efa9624174d5f892c1688b11b62b1
Autor:
K R S NARESH GATTA, Lalitha Guruprasad
Publikováno v:
Journal of Biomolecular Structure and Dynamics. :1-21
The dynamically active and inactive conformations of kinases play a crucial role in the activation of intracellular downstream signaling pathways. The all-atom molecular dynamics (MD) simulations at microsecond (µs) timescale and longer provide robu