Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Lalitha, Madhavan"'
Publikováno v:
Frontiers in Aging, Vol 2 (2021)
Redox and metabolic mechanisms lie at the heart of stem cell survival and regenerative activity. NRF2 is a major transcriptional controller of cellular redox and metabolic homeostasis, which has also been implicated in ageing and lifespan regulation.
Externí odkaz:
https://doaj.org/article/fd8630174f0449b89908c51d7d14359d
Autor:
Joji M. Y. Teves, Vedanshi Bhargava, Konner R. Kirwan, Mandi J. Corenblum, Rebecca Justiniano, Georg T. Wondrak, Annadurai Anandhan, Andrew J. Flores, David A. Schipper, Zain Khalpey, James E. Sligh, Clara Curiel-Lewandrowski, Scott J. Sherman, Lalitha Madhavan
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2018)
The discovery of biomarkers for Parkinson's disease (PD) is challenging due to the heterogeneous nature of this disorder, and a poor correlation between the underlying pathology and the clinically expressed phenotype. An ideal biomarker would inform
Externí odkaz:
https://doaj.org/article/9ad1611616794f698a5e164053c27bad
Autor:
Jana, Jandova, Sophia L, Park, Mandi J, Corenblum, Lalitha, Madhavan, Jeremy A, Snell, Liliana, Rounds, Georg T, Wondrak
Publikováno v:
Mol Carcinog
Molecularly targeted therapeutics have revolutionized the treatment of BRAF(V600E)-driven malignant melanoma, but the rapid development of resistance to BRAF kinase inhibitors (BRAFi) presents a significant obstacle. The use of clinical antimalarials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::26851e85354cacdd119d69fdc0ec2998
https://pubmed.ncbi.nlm.nih.gov/35417045
https://pubmed.ncbi.nlm.nih.gov/35417045
Autor:
Jeffrey H. Kordower, Hemraj B. Dodiya, Adam M. Kordower, Brian Terpstra, Katrina Paumier, Lalitha Madhavan, Caryl Sortwell, Kathy Steece-Collier, Timothy J. Collier
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 3, Pp 552-557 (2011)
Multiple laboratories have recently demonstrated that long-term dopaminergic transplants form Lewy bodies in patients with Parkinson's disease. Debate has arisen as to whether these Lewy bodies form from the transfer of alpha synuclein from the host
Externí odkaz:
https://doaj.org/article/0471daa89b83453796a2a21cd72a7e8d
Autor:
Christopher R. Apostol, Kelsey Bernard, Parthasaradhireddy Tanguturi, Gabriella Molnar, Mitchell J. Bartlett, Lajos Szabò, Chenxi Liu, J. Bryce Ortiz, Maha Saber, Katherine R. Giordano, Tabitha R. F. Green, James Melvin, Helena W. Morrison, Lalitha Madhavan, Rachel K. Rowe, John M. Streicher, Michael L. Heien, Torsten Falk, Robin Polt
Publikováno v:
Frontiers in Drug Discovery. 1
There is an unmet clinical need for curative therapies to treat neurodegenerative disorders. Most mainstay treatments currently on the market only alleviate specific symptoms and do not reverse disease progression. The Pituitary adenylate cyclase-act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c196051e4fec6350d54a9817d75cf236
https://doi.org/10.3389/fddsv.2021.818003
https://doi.org/10.3389/fddsv.2021.818003
Autor:
Lalitha Madhavan, Brian F Daley, Beverly L Davidson, Ryan L Boudreau, Jack W Lipton, Allyson Cole-Strauss, Kathy Steece-Collier, Timothy J Collier
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137136 (2015)
The expression of soluble growth and survival promoting factors by neural precursor cells (NPCs) is suggested to be a prominent mechanism underlying the protective and regenerative effects of these cells after transplantation. Nevertheless, how and t
Externí odkaz:
https://doaj.org/article/d53849eccd9d4d67ad703563bcd3b726
Publikováno v:
Frontiers in Aging. 2
Redox and metabolic mechanisms lie at the heart of stem cell survival and regenerative activity. NRF2 is a major transcriptional controller of cellular redox and metabolic homeostasis, which has also been implicated in ageing and lifespan regulation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b81d826feceb45a2c5f8505eb38d81
https://doi.org/10.3389/fragi.2021.690686
https://doi.org/10.3389/fragi.2021.690686
Publikováno v:
Aging Cell
Although it is known that aging affects neural stem progenitor cell (NSPC) biology in fundamental ways, the underlying dynamics of this process are not fully understood. Our previous work identified a specific critical period (CP) of decline in NSPC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ff0e6943b8209a8bd60bb4eb3aaea3
http://europepmc.org/articles/PMC8208782
http://europepmc.org/articles/PMC8208782
Autor:
Annadurai Anandhan, Mandi J. Corenblum, Sneha Ray, Americus Reed, F. O. Ortiz, Carol A. Barnes, Donna D. Zhang, Lalitha Madhavan
Publikováno v:
Cell Transplantation, Vol 27 (2018)
Cell Transplantation
Cell Transplantation
Redox mechanisms are emerging as essential to stem cell function given their capacity to influence a number of important signaling pathways governing stem cell survival and regenerative activity. In this context, our recent work identified the reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69bd03c14dfa1c3baa3a67bad8db441
https://doi.org/10.1177/0963689718774030
https://doi.org/10.1177/0963689718774030
Autor:
Mandi J. Corenblum, Lalitha Madhavan, Carol A. Barnes, Donna D. Zhang, Min Long, Sneha Ray, Bryan Harder, Quentin W. Remley
Publikováno v:
Aging Cell
Summary Although it is known that the regenerative function of neural stem/progenitor cells (NSPCs) declines with age, causal mechanisms underlying this phenomenon are not understood. Here, we systematically analyze subventricular zone (SVZ) NSPCs, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6790c403fd193fde0613c7e9d0fffe9
https://doi.org/10.1111/acel.12482
https://doi.org/10.1111/acel.12482