Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Lalita Ramakrishnan"'
Autor:
Lalita Ramakrishnan
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 3 (2023)
Professor Lalita Ramakrishnan is at the forefront of modern tuberculosis (TB) research. She has developed vital tools, most notably a robust zebrafish model, to study this disease, leading to seminal discoveries uncovering bacterial and host interact
Externí odkaz:
https://doaj.org/article/b0ecdab2f75748f6beac00b45e02a24c
Autor:
Kevin K Takaki, Francisco J Roca, Gabriele Schramm, Ruud H P Wilbers, Wannaporn Ittiprasert, Paul J Brindley, Gabriel Rinaldi, Matthew Berriman, Lalita Ramakrishnan, Antonio J Pagán
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0008814 (2021)
Infections by schistosomes result in granulomatous lesions around parasite eggs entrapped within the host tissues. The host and parasite determinants of the Schistosoma mansoni egg-induced granulomatous response are areas of active investigation. Som
Externí odkaz:
https://doaj.org/article/61da5d83500e4279a2033dc12ad60ad2
Autor:
Laura Whitworth, Jacob Coxon, Arjan van Laarhoven, Nguyen Thuy Thuong Thuong, Sofiati Dian, Bachti Alisjahbana, Ahmad Rizal Ganiem, Reinout van Crevel, Guy E Thwaites, Mark Troll, Paul H Edelstein, Roger Sewell, Lalita Ramakrishnan
Publikováno v:
eLife, Vol 10 (2021)
Tuberculous meningitis has high mortality, linked to excessive inflammation. However, adjunctive anti-inflammatory corticosteroids reduce mortality by only 30%, suggesting that inflammatory pathophysiology causes only a subset of deaths. In Vietnam,
Externí odkaz:
https://doaj.org/article/e5091ac19b1c47789b6044b32485ac7f
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0233252 (2020)
Phthiocerol dimycocerosates (PDIMs) are a class of mycobacterial lipids that promote virulence in Mycobacterium tuberculosis and Mycobacterium marinum. It has recently been shown that PDIMs work in concert with the M. tuberculosis Type VII secretion
Externí odkaz:
https://doaj.org/article/897e218d943c4c9781e5587fde7e344e
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194982 (2018)
Ocular tuberculosis (TB) commonly causes severe inflammation and vision loss in TB-endemic countries. The mechanism by which tuberculous infection becomes established in the eye is poorly understood. We have developed the zebrafish larva infected wit
Externí odkaz:
https://doaj.org/article/b9190b0505b24342ba33c8856d9ab88a
Autor:
Didier Y R Stainier, Erez Raz, Nathan D Lawson, Stephen C Ekker, Rebecca D Burdine, Judith S Eisen, Philip W Ingham, Stefan Schulte-Merker, Deborah Yelon, Brant M Weinstein, Mary C Mullins, Stephen W Wilson, Lalita Ramakrishnan, Sharon L Amacher, Stephan C F Neuhauss, Anming Meng, Naoki Mochizuki, Pertti Panula, Cecilia B Moens
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007000 (2017)
Externí odkaz:
https://doaj.org/article/62a8b7c4acd2462ea67aa80d02b01eb3
Publikováno v:
Cell Reports, Vol 2, Iss 1, Pp 175-184 (2012)
Treatment of tuberculosis, like other infectious diseases, is increasingly hindered by the emergence of drug resistance. Drug discovery efforts would be facilitated by facile screening tools that incorporate the complexities of human disease. Mycobac
Externí odkaz:
https://doaj.org/article/0f8b024d25f8417a87b08a546942a4dc
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 7, Pp 731-733 (2014)
In recent years, the zebrafish has emerged as an increasingly prominent model in biomedical research. To showcase the translational impact of the model across multiple disease areas, Disease Models & Mechanisms has compiled a Special Issue that inclu
Externí odkaz:
https://doaj.org/article/671f4ee22239469c8484f1fca65f7959
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67828 (2013)
While tuberculosis susceptibility has historically been ascribed to failed inflammation, it is now known that an excess of leukotriene A4 hydrolase (LTA4H), which catalyzes the final step in leukotriene B4 (LTB4) synthesis, produces a hyperinflammato
Externí odkaz:
https://doaj.org/article/c52964ffc36e486081094a0890c05709
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 3, Iss 6, p e463 (2009)
Leptospirosis is an extremely widespread zoonotic infection with outcomes ranging from subclinical infection to fatal Weil's syndrome. Despite the global impact of the disease, key aspects of its pathogenesis remain unclear. To examine in detail the
Externí odkaz:
https://doaj.org/article/29c3d263b13b42c7ad12c02b8b184708