Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Lalit K, Golani"'
Autor:
Lalit K. Golani, Donna M. Platt, Daniela Rüedi-Bettschen, Chitra Edwanker, Shenming Huang, Michael M. Poe, Roman Furtmüller, Werner Sieghart, James M. Cook, James K. Rowlett
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
In order to develop improved anxiolytic drugs, 8-substituted analogs of triazolam were synthesized in an effort to discover compounds with selectivity for α2/α3 subunit-containing GABAA subtypes. Two compounds in this series, XLi-JY-DMH (6-(2-chlor
Externí odkaz:
https://doaj.org/article/a95252a7ff224cdca9d223b58e02c490
Autor:
Xingjie Ping, Michelle J. Meyer, Nicolas M. Zahn, Lalit K. Golani, Dishary Sharmin, Kamal P. Pandey, Sepideh Revanian, Prithu Mondal, Xiaoming Jin, Leggy A. Arnold, Rok Cerne, James M. Cook, Branka Divović, Miroslav M. Savić, Arnold Lippa, Jodi L. Smith, Jeffrey M. Witkin
Publikováno v:
Drug Development Research
A series of imidazodiazepines has been developed that possess reduced sedative liabilities but retain efficacy in anticonvulsant screening models. The latest of these compounds, (5-(8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazole[1,5-α][1,4]diazepin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd92e068ef9c959ec71ac2decf0fe410
https://doi.org/10.1002/ddr.22042
https://doi.org/10.1002/ddr.22042
Autor:
Kamal P. Pandey, Branka Divović, Farjana Rashid, Lalit K. Golani, Rok Cerne, Nicolas M. Zahn, Michelle Jean Meyer, Leggy A. Arnold, Dishary Sharmin, Md Yeunus Mian, Jodi L. Smith, Xingjie Ping, Xiaoming Jin, Arnold Lippa, V.V.N. Phani Babu Tiruveedhula, James M. Cook, Miroslav M. Savić, Jeffrey M. Witkin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 385:50-61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79150d8e7e1712b0c4f2b466b3c9c84f
https://doi.org/10.1124/jpet.122.001362
https://doi.org/10.1124/jpet.122.001362
Autor:
Md Yeunus Mian, Prithu Mondal, Dishary Sharmin, Kamal P. Pandey, Farjana Rashid, Sepideh Rezvanian, Lalit K. Golani, V.V.N. Phani Babu Tiruveedhula, Vilashini Rajaratnam, Shama P. Mirza, John D. Chan, Jeffrey M. Witkin, James M. Cook
Publikováno v:
Arkivoc. 2021:171-188
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9768ed2314885310c867ef6926a791f
https://doi.org/10.24820/ark.5550190.p011.712
https://doi.org/10.24820/ark.5550190.p011.712
Deficiencies in standard of care antidepressants are driving novel drug discovery. A new age of antidepressant medications has emerged with the introduction of rapid-acting antidepressants with efficacy in treatment-resistant patients. The newly appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed18cfc2b23c557c19c389cc37a5055
Publikováno v:
Current Enzyme Inhibition. 17:111-119
Background: Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder with complex aetiology and phenotypes. Maternal consumption of alcohol is known to produce deleterious effects in the progeny, generating ADHD-related phenot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53afa7933c28a914c9de257a1b38f0da
https://doi.org/10.2174/1573408017666210203202024
https://doi.org/10.2174/1573408017666210203202024
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bac1b93b268b1ef54a6603dcc5d54db
https://doi.org/10.1002/0471266949.bmc099.pub3
https://doi.org/10.1002/0471266949.bmc099.pub3
Autor:
Md Yeunus Mian, Branka Divović, Dishary Sharmin, Kamal P. Pandey, Lalit K. Golani, V. V. N. Phani Babu Tiruveedhula, Rok Cerne, Jodi L. Smith, Xingjie Ping, Xiaoming Jin, Gregory H. Imler, Jeffrey R. Deschamps, Arnold Lippa, James M. Cook, Miroslav M. Savić, James Rowlett, Jeffrey M. Witkin
Publikováno v:
ACS Omega
Imidazodiazepine (5-(8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazole[1,5-α][1,4]diazepin-3-yl) oxazole or KRM-II-81) is a potentiator of GABAA receptors (a GABAkine) undergoing preparation for clinical development. KRM-II-81 is active against many s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5ead1f3451334a5b9575b1f28e4be7
https://pubmed.ncbi.nlm.nih.gov/35967038
https://pubmed.ncbi.nlm.nih.gov/35967038
Publikováno v:
Behav Pharmacol
Benzodiazepines bind to and act on α1–3 and α5-containing GABA(A) receptors. Previous studies suggest that different GABA(A) receptor α-subtypes mediate the various behavioral effects of benzodiazepines, which raises the possibility of combining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135ab9e28426c3fa29993784fc47198a
https://doi.org/10.1097/fbp.0000000000000614
https://doi.org/10.1097/fbp.0000000000000614
Autor:
Prithu Mondal, Dishary Sharmin, Sepideh Rezvanian, Farjana Rashid, Daniel E. Knutson, Lalit K. Golani, Jeffrey M. Witkin, Yeunus Mian, Leggy A. Arnold, Taukir Ahmed, V. V. N. Phani Babu Tiruveedhula, Kamal P. Pandey, Nicolas M Zahn, Zubair Ahmed Khan, James M. Cook
Publikováno v:
ARKIVOC
Antinociceptive ligand HZ-166 is a GABA(A) α2/α3 receptor subtype-selective potentiator. It has been shown to exhibit anxiolytic-like effects in rodent and rhesus monkeys, as well as reduced sedative/ataxic liabilities. In order to improve the meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de30f35e665a32f2190f339788d9626f
https://doi.org/10.24820/ark.5550190.p011.398
https://doi.org/10.24820/ark.5550190.p011.398