Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Lali K Medina-Kauwe"'
Autor:
Jae Youn Hwang, Jinhyoung Park, Bong Jin Kang, David J Lubow, David Chu, Daniel L Farkas, K Kirk Shung, Lali K Medina-Kauwe
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34463 (2012)
This study presents a new multimodal imaging approach that includes high-frequency ultrasound, fluorescence intensity, confocal, and spectral imaging to improve the preclinical evaluation of new therapeutics in vivo. Here we use this approach to asse
Externí odkaz:
https://doaj.org/article/4c50ec0627ff4181910e109a6419074d
Autor:
Zhe Wang, Xinfeng Zhang, Lali K. Medina-Kauwe, Xiaojiang Cui, Tian-Yu Lee, Neil A. Bhowmick, Ying Zhang, Bingchen Han, Stephen L. Shiao, Xuemo Fan, Felix Alonso-Valenteen, Nan Deng, Bowen Gao, Armando E. Giuliano, Yali Xu, Sandrine Billet
Publikováno v:
Molecular Therapy. 30:672-687
Triple-negative breast cancer (TNBC) has a high propensity for organ-specific metastasis. However, the underlying mechanisms are not well understood. Here we show that the primary TNBC tumor-derived C-X-C motif chemokines 1/2/8 (CXCL1/2/8) stimulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6c7caee7845bb6066a0776b2739ba9
https://doi.org/10.1016/j.ymthe.2021.07.003
https://doi.org/10.1016/j.ymthe.2021.07.003
Autor:
Jae Youn Hwang, Dustin Srinivas, Lali K Medina Kauwe, Felix Alonso-Valenteen, Sayuri Pacheco, Altan Rentsendorj, Simoun Mikhael, David Chu, Ravinder Abrol, Tianxin Miao, Jessica Sims, Jay Lubow
Publikováno v:
Nucleic Acids Research
RNA interference represents a potent intervention for cancer treatment but requires a robust delivery agent for transporting gene-modulating molecules, such as small interfering RNAs (siRNAs). Although numerous molecular approaches for siRNA delivery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76831b6c7acf2b906d262f4aee469218
https://doi.org/10.1093/nar/gkz900
https://doi.org/10.1093/nar/gkz900
Publikováno v:
BioTechniques, Vol 29, Iss 3, Pp 602-609 (2000)
We have developed a simple scheme for characterizing ligand-receptor binding and post-binding activity on living cells. Our approach makes use of green fluorescent protein (GFP) as an auto-fluorescent tag to label protein ligands. We have constructed
Externí odkaz:
https://doaj.org/article/80e09833ad8a40679c8df536389377f3
Autor:
Weiliang Chen, Kayo Nakamura, Yinsong Zhu, Francisco Javier Lopez-Tapia, Casie Kubota, Wenzhen Fu, James Turkson, Felix Alonso-Valenteen, Lali K. Medina-Kauwe, Christine Brotherton-Pleiss, Jasmine Chen, Peibin Yue, Simoun Mikhael, Marcus A. Tius
Publikováno v:
Journal of Medicinal Chemistry
We optimized our previously reported proline-based STAT3 inhibitors into an exciting new series of (R)-azetidine-2-carboxamide analogues that have sub-micromolar potencies. 5a, 5o, and 8i have STAT3-inhibitory potencies (IC50) of 0.55, 0.38, and 0.34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e274d60b9b4117f5dee95ca2720723
https://pubmed.ncbi.nlm.nih.gov/33352047
https://pubmed.ncbi.nlm.nih.gov/33352047
Publikováno v:
Neurobiology of Disease, Vol 5, Iss 2, Pp 89-96 (1998)
GABA-transaminase (GABA-T) deficiency disease is a rare recessive disorder characterized by abnormal development, seizures, and high levels of GABA in serum and cerebrospinal fluid. Although some patients are the offspring of consanguineous marriages
Externí odkaz:
https://doaj.org/article/54adc0d78e6045eeafd18923ba55cac4
Autor:
Amrita Rao, Mythili Dileepan, Bit Na Kang, Savita P. Rao, Xiao Na Ge, Sung Gil Ha, P. Sriramarao, Scott M. O'Grady, Girija Muralidhar, Michael A. Thompson, Yana G. Greenberg, Lali K. Medina-Kauwe, Christina M. Pabelick
Publikováno v:
The Journal of allergy and clinical immunology, vol 142, iss 6
Background Altered epithelial physical and functional barrier properties along with TH1/TH2 immune dysregulation are features of allergic asthma. Regulation of junction proteins to improve barrier function of airway epithelial cells has the potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd08d1430a8a6dbece3287f5973a6d8
https://escholarship.org/uc/item/14g983qp
https://escholarship.org/uc/item/14g983qp
Autor:
Harry B. Gray, Eduardo Marbán, A. Chung, M. Taguiam, Rex Moats, Felix Alonso-Valenteen, Armando E. Giuliano, Chris Hanson, Jessica Sims, Zeev Gross, Xiaojiang Cui, Karn R. Sorasaenee, Shawn Wagner, Lali K. Medina-Kauwe
Publikováno v:
Cancer Research. 76:P6-17
Patients with breast cancer metastases to the brain on average survive less than one year. These tumors tend to be resistant to current therapies, and the majority of targeted therapeutics are unable to breach the blood brain barrier (BBB) to reach t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6fb9d9703c74cb78f713206638c7e55
https://doi.org/10.1158/1538-7445.sabcs15-p6-17-05
https://doi.org/10.1158/1538-7445.sabcs15-p6-17-05
Publikováno v:
Cancer Research. 76:P3-12
Background: Radiation is the current choice treatment for non-operable metastatic breast-brain cancer. When cancer lesions are located in sensitive areas like the brain or have excessive amounts of metastatic sites, radiation usually proves to be a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cb8df37ab3a2447a09356b60df0e60f
https://doi.org/10.1158/1538-7445.sabcs15-p3-12-13
https://doi.org/10.1158/1538-7445.sabcs15-p3-12-13
Autor:
Jan Michael Taguiam, David Chu, Jay Lubow, Jenny Lester, Beth Y. Karlan, Hasmik Agadjanian, Ravinder Abrol, Janet L. Markman, Jae Youn Hwang, Bingchen Han, Harry B. Gray, Dustin Srinivas, Armando E. Giuliano, Altan Rentsendorj, Zeev Gross, Lali K. Medina-Kauwe, Jessica Sims, Anjali Jain, Xiaojiang Cui, Ying Qu, Felix Alonso-Valenteen, Parisa Mirzadehgan, Alice Chung
Publikováno v:
Sims, JD; Taguiam, JM; Alonso-Valenteen, F; Markman, J; Agadjanian, H; Chu, D; et al.(2018). Resistance to receptor-blocking therapies primes tumors as targets for HER3-homing nanobiologics. JOURNAL OF CONTROLLED RELEASE, 271, 127-138. doi: 10.1016/j.jconrel.2017.12.024. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4597954h
Resistance to anti-tumor therapeutics is an important clinical problem. Tumor-targeted therapies currently used in the clinic are derived from antibodies or small molecules that mitigate growth factor activity. These have improved therapeutic efficac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7627b2d486f165125288cd20e7359ee
https://escholarship.org/uc/item/4597954h
https://escholarship.org/uc/item/4597954h