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pro vyhledávání: '"Lalgudi S"'
Akademický článek
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Autor:
Harikrishnan, Lalgudi S., Warrier, Jayakumar, Tebben, Andrew J., Tonukunuru, Gopikishan, Madduri, Sudhakara R., Baligar, Vishweshwaraiah, Mannoori, Raju, Seshadri, Balaji, Rahaman, Hasibur, Arunachalam, P.N., Dikundwar, Amol G., Fink, Brian E., Fargnoli, Joseph, Fereshteh, Mark, Fan, Yi, Lippy, Jonathan, Ho, Ching-Ping, Wautlet, Barri, Sheriff, Steven, Ruzanov, Max, Borzilleri, Robert M.
Publikováno v:
In Bioorganic & Medicinal Chemistry 1 March 2018 26(5):1026-1034
Autor:
Ching Kim Tye, Chunhong Yan, Sarah C. Traeger, Wayne Vaccaro, Yingru Zhang, Gerry Everlof, Jianqing Li, Henry Yip, Peng Li, John T. Hunt, Michael A. Poss, Gregory D. Vite, Mussari Christopher P, Steven Sheriff, Asoka Ranasinghe, Haiying Zhang, Richard A. Westhouse, Dharmpal S. Dodd, Richard Rampulla, Zheng Yang, Frank Marsilio, Derek J. Norris, Wen-Ching Han, Tram N. Huynh, Yufen Zhao, Patrice Gill, Nirmala Raghavan, Lalgudi S. Harikrishnan, Ashvinikumar V. Gavai, Susan Wee, John S. Tokarski, Dauh-Rurng Wu, Arvind Mathur, Mei-Li Wen, Huiping Zhang, David R. Tortolani, George V. Delucca, Krista Menard, Francis Y. Lee, Claude A. Quesnelle, Dawn Sun, Vijay T. Ahuja, Daniel O'malley, Christine Huang, Muthoni G. Kamau
Publikováno v:
Journal of Medicinal Chemistry. 64:14247-14265
Inhibition of the bromodomain and extra-terminal (BET) family of adaptor proteins is an attractive strategy for targeting transcriptional regulation of key oncogenes, such as c-MYC. Starting with the screening hit 1, a combination of structure-activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6552024d7da4fe4ccaa968fbe1cf079
https://doi.org/10.1021/acs.jmedchem.1c00625
https://doi.org/10.1021/acs.jmedchem.1c00625
Autor:
Kamau, Muthoni G., Harikrishnan, Lalgudi S., Finlay, Heather J., Qiao, Jennifer X., Jiang, Ji, Poss, Michael A., Salvati, Mark E., Wexler, Ruth R., Lawrence, R. Michael
Publikováno v:
In Tetrahedron 25 March 2012 68(12):2696-2703
Autor:
Ji Jiang, Tammy C. Wang, Alice Ye A. Chen, Xiaohong Yin, Jennifer X. Qiao, Ming Chang, Muthoni G. Kamau, Julia Li, David S. Taylor, Leonard P. Adam, Lalgudi S. Harikrishnan, Xue-Qing Chen, Heather Finlay, R. Michael Lawrence, Richard Rampulla, Paul Levesque, Christine Huang, Paul G. Sleph, Carrie Xu, Ruth R. Wexler, Mark E. Salvati
Publikováno v:
ACS Med Chem Lett
[Image: see text] Lead optimization of the diphenylpyridylethanamine (DPPE) and triphenylethanamine (TPE) series of CETP inhibitors to improve their pharmaceutical profile is described. Polar groups at the N-terminus position in the DPPE series resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0dc9b771eed0176133985ac09f68ab
https://doi.org/10.1021/acsmedchemlett.9b00086
https://doi.org/10.1021/acsmedchemlett.9b00086
Autor:
Ruan, Zheming, Park, Peter K., Wei, Donna, Purandare, Ashok, Wan, Honghe, O'Malley, Daniel, Stachura, Sylwia, Perez, Heidi, Cavallaro, Cullen L., Weigelt, Carolyn A., Sack, John S., Ruzanov, Max, Khan, Javed, Gururajan, Murali, Wong, Jessica J., Huang, Yanling, Yarde, Melissa, Li, Zhuyin, Chen, Cliff, Sun, Huadong, Borowski, Virna, Xie, Jenny H., Anthony, Monique, Agler, Michele, Fink, Brian E., Harikrishnan, Lalgudi S.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 March 2021 35
Autor:
Zhenqiu Hong, Brian E. Fink, Darpandeep Aulakh, Peng Li, Gregory D. Vite, Xiaoping Hou, Dawn Sun, Aaron Smith, Bei Wang, Amy A. Sarjeant, James Kempson, Arvind Mathur, Lan-Ying Qin, Martins S. Oderinde, Rulin Zhao, Peter K. Park, Lalgudi S. Harikrishnan, Dauh-Rurng Wu, Joseph Pawluczyk, Cornelius Lyndon A M, Huiping Zhang, Janet Caceres-Cortes, Shiuhang Yip, Dharmpal S. Dodd
Publikováno v:
The Journal of organic chemistry. 86(13)
We describe a stereodefined synthesis of the newly identified non-natural phosphorothioate cyclic dinucleotide (CDN) STING agonist, BMT-390025. The new route avoids the low-yielding racemic approach using P(III)-based reagents, and the stereospecific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6369d2614241414c22a55b878cc89a63
https://pubmed.ncbi.nlm.nih.gov/34126006
https://pubmed.ncbi.nlm.nih.gov/34126006
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Harikrishnan, Lalgudi S., Gill, Patrice, Kamau, Muthoni G., Qin, Lan-Ying, Ruan, Zheming, O'Malley, Daniel, Huynh, Tram, Stachura, Sylwia, Cavallaro, Cullen L., Lu, Zhonghui, J.-W. Duan, James, Weigelt, Carolyn A., Sack, John S., Ruzanov, Max, Khan, Javed, Gururajan, Murali, Wong, Jessica J., Huang, Yanling, Yarde, Melissa, Li, Zhuyin, Chen, Cliff, Sun, Huadong, Borowski, Virna, Murtaza, Anwar, Fink, Brian E.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 15 June 2020 30(12)
Autor:
Yanling Huang, Jingwu Duan, Carolyn A. Weigelt, Cullen L. Cavallaro, Javed Khan, Brian E. Fink, Muthoni G. Kamau, Zheming Ruan, Lan-Ying Qin, Sylwia Stachura, Cliff Chen, Murali Gururajan, Lalgudi S. Harikrishnan, Tram N. Huynh, John S. Sack, Anwar Murtaza, Daniel O'malley, Zhuyin Li, Melissa Yarde, Max Ruzanov, Virna Borowski, Patrice Gill, Huadong Sun, Zhonghui Lu, Jessica J. Wong
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(12)
Substituted benzyloxy aryl compound 2 was identified as an RORγt agonist. Structure based drug design efforts resulted in a potent and selective tricyclic compound 19 which, when administered orally in an MC38 mouse tumor model, demonstrated a desir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d28391368dbe9fe0275182d85ed69ba6
https://pubmed.ncbi.nlm.nih.gov/32334911
https://pubmed.ncbi.nlm.nih.gov/32334911