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Estrogen differentially regulates the expression of tyrosine hydroxylase and nerve growth factor through free radical generation in the thymus and mesenteric lymph nodes of middle-aged ovariectomized female Sprague-Dawley rats

Autor: Sunil Karrunanithi, Hannah P. Priyanka, Srinivasan ThyagaRajan, Uday P. Pratap, Lalgi Hima, Kishore A. Ravichandran

Publikováno v: Clinical and Experimental Neuroimmunology. 8:341-350

Objective Sympathetic neuronal activity in the thymus and lymph nodes is differentially regulated during reproductive aging. The aim was to investigate the role of estrogen on sympathetic neuronal expression in the thymus and mesenteric lymph nodes o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e1350c4459eca886d53de8061dbba60
https://doi.org/10.1111/cen3.12415

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Noni ( Morinda citrifolia L.) fruit juice reverses age-related decline in neural-immune interactions in the spleens of old F344 rats

Autor: Srinivasan ThyagaRajan, Uday P. Pratap, Lalgi Hima, Hannah P. Priyanka

Publikováno v: Journal of Ethnopharmacology. 198:363-371

Ethnopharmacological relevance Various parts of the tropical plant, Morinda citrifolia L. (Noni), have been widely used in traditional medicine in South and Southeast Asia for several centuries. The therapeutic effects of the noni are believed to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea93be86ea1f19cc25eb2ab7c4b4dea
https://doi.org/10.1016/j.jep.2017.01.034

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Virgin coconut oil supplementation in diet modulates immunity mediated through survival signaling pathways in rats

Autor: Kishore A. Ravichandran, Lalgi Hima, Srinivasan ThyagaRajan, Sunil Karrunanithi, Uday P. Pratap, Ramasamy Vasantharekha

Publikováno v: Journal of Complementary and Integrative Medicine. 17

BackgroundVirgin coconut oil (VCO), a cold processed form of coconut oil, is traditionally consumed in Asian countries owing to its nutritional and medicinal properties. The aim of this study was to investigate whether the health benefits of VCO invo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79472cc2411ed98eef3836e72fd32eb1
https://doi.org/10.1515/jcim-2019-0114

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Sex-Based Differences in the Cytokine Production and Intracellular Signaling Pathways in Patients With Rheumatoid Arthritis

Autor: Srinivasan ThyagaRajan, Lalgi Hima, Ramasamy Vasantharekha, Chadrasekaran Thyagarajan, Hannah P. Priyanka, Thangamani Kannan, Uday P. Pratap, Anand Pushparani

Publikováno v: Archives of Rheumatology

Objectives This study aims to investigate lymphoproliferation, cytokine production, and intracellular signaling molecules in peripheral blood mononuclear cells (PBMCs) isolated from healthy individuals and rheumatoid arthritis (RA) patients to unders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8539ae9836acc3d71427caa1c55706e
https://pubmed.ncbi.nlm.nih.gov/33758811

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Age-associated decline in neural, endocrine, and immune responses in men and women: Involvement of intracellular signaling pathways

Autor: Mantavya N. Patel, Thangamani Kannan, Lalgi Hima, Uday P. Pratap, Shaili Gour, Ramasamy Vasantharekha, Srinivasan ThyagaRajan, Hannah P. Priyanka

Publikováno v: Journal of Neuroimmunology. 345:577290

The aim of this study was to investigate the alterations in the neuroendocrine-immune functions by using human peripheral blood mononuclear cells (hPBMCs) from three age groups (young, middle-aged, and old) of men and women for the analyses of lympho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb780f78532748df006d99ed5b6723b7
https://doi.org/10.1016/j.jneuroim.2020.577290

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Estrogen upregulates inflammatory signals through NF-κB, IFN-γ, and nitric oxide via Akt/mTOR pathway in the lymph node lymphocytes of middle-aged female rats

Autor: Srinivasan ThyagaRajan, Prathamesh Kale, Srinivasan Gopinath, Himanshu Sharma, Lalgi Hima, Uday P. Pratap, Hannah P. Priyanka, Aparna Mohanty

Publikováno v: International Immunopharmacology. 29:591-598

The alterations in the secretion of sex steroids, especially estrogen, in females throughout reproductive life and its decline with age alters the functions of the neuroendocrine-immune network and renders them susceptible to age-related diseases and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3072f656c30c0d4545608b0f6794ad0f
https://doi.org/10.1016/j.intimp.2015.09.024

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Phytochemicals inMorinda citrifoliafruit selectively modulate age-associated immunity and antioxidant enzyme activities through ERK pathway in splenic lymphocytes of male F344 rats

Autor: Hannah P. Priyanka, Uday P. Pratap, Lalgi Hima, Krithika Anand, Srinivasan ThyagaRajan, Fariya Yasmine

Publikováno v: Journal of Receptors and Signal Transduction. 36:139-151

The mechanisms of immunomodulatory effects of Morinda citrifolia (Noni) were examined through intracellular signaling pathways in the splenocytes and their modulation by phytochemicals using bioinformatics tools.Noni fruit juices without seeds (NSL)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904b3129b7584265198eeb5539243759
https://doi.org/10.3109/10799893.2015.1061001

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Noni (Morinda citrifolia L.) fruit juice delays immunosenescence in the lymphocytes in lymph nodes of old F344 rats

Autor: Vishak Raman, Lalgi Hima, Uday P. Pratap, Hannah P. Priyanka, Srinivasan ThyagaRajan, Karthik R. Ramanathan

Publikováno v: Journal of integrative medicine. 16(3)

Objective Aging is associated with the development of diseases because of immunosuppression and altered functioning of the neuroendocrine system. The medicinal properties of Morinda citrifolia L. have been widely exploited for the treatment of age-as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554700ceb1b8439db49aefd5981dbdc7
https://pubmed.ncbi.nlm.nih.gov/29691190

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