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Autor:
Hea Ok Kim, Young Hoon Jung, Hyuk Woo Lee, Amit Patel, Won Jun Choi, Lalc Shin Jeong, Kenneth A. Jacobson, Moshe Chinn, Zhan-Guo Gao, Hyung Ryong Moon
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:8003-8011
On the basis of a bioisosteric rationale, 4'-thionucleoside analogues of IB-MECA (N(6)-(3-Iodo-benzyl)-9-(5'-methylaminocarbonyl-beta-d-ribofuranosyl)adenine), which is a potent and selective A(3) adenosine receptor (AR) agonist, were synthesized fro