Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Laktyushin, A. A."'
Autor:
Rhiannon Morris, Narelle Keating, Cyrus Tan, Hao Chen, Artem Laktyushin, Tamanna Saiyed, Nicholas P. D. Liau, Nicos A. Nicola, Tony Tiganis, Nadia J. Kershaw, Jeffrey J. Babon
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Protein Tyrosine Phosphatase 1B (PTP1B) is the prototypical protein tyrosine phosphatase and plays an essential role in the regulation of several kinase-driven signalling pathways. PTP1B displays a preference for bisphosphorylated substrates
Externí odkaz:
https://doaj.org/article/fe7ce3bae9694500a0f1ccbffabd3899
Autor:
Rhiannon Morris, Yaoyuan Zhang, Julia I. Ellyard, Carola G. Vinuesa, James M. Murphy, Artem Laktyushin, Nadia J. Kershaw, Jeffrey J. Babon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
LNK is a potent negative regulator of cytokine signaling implicated in blood cells proliferation. Here the authors present structures of the substrate recognition (SH2) domain of LNK in complex with phosphorylated motifs from JAK2 and EPOR; providing
Externí odkaz:
https://doaj.org/article/ed728d0a0b344b1398b0296e28357e0b
Publikováno v:
AIP Conference Proceedings; 2023, Vol. 2624 Issue 1, p1-5, 5p
Autor:
Nicholas P. D. Liau, Artem Laktyushin, Isabelle S. Lucet, James M. Murphy, Shenggen Yao, Eden Whitlock, Kimberley Callaghan, Nicos A. Nicola, Nadia J. Kershaw, Jeffrey J. Babon
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Cytokines are key molecules in controlling haematopoiesis that signal via the JAK/STAT pathway. Here the authors present the structures of SOCS1 bound to its JAK1 target as well as in complex with elonginB and elonginC, providing a molecular explanat
Externí odkaz:
https://doaj.org/article/e82cd8b59644469288505cb69474018c
Akademický článek
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Autor:
James M. Murphy, Yaoyuan Zhang, Nadia J. Kershaw, Jeffrey J. Babon, Carola G. Vinuesa, Julia I. Ellyard, Rhiannon Morris, Artem Laktyushin
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The SH2B family of adaptor proteins, SH2-B, APS, and LNK are key modulators of cellular signalling pathways. Whilst SH2-B and APS have been partially structurally and biochemically characterised, to date there has been no such characterisation of LNK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b838afedef260a30e80a6bd8b75a38a1
https://pubmed.ncbi.nlm.nih.gov/34671038
https://pubmed.ncbi.nlm.nih.gov/34671038
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Dina Stockwell, Nicos A. Nicola, Alan Ching, Satoshi Ishido, Douglas J. Hilton, Jeffrey J. Babon, Warren S. Alexander, Artem Laktyushin, Jose A Villadangos, Jian-Guo Zhang, Ladina DiRago
Publikováno v:
Biochemical Journal. 476:2869-2882
Interleukin 6 (IL6) is a cytokine that regulates a number of important immune and inflammatory pathways. We used the ability of IL6 to inhibit the clonal proliferation of the mouse M1 myeloid leukemia cell line in agar to positively screen a cDNA exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a5d911c84c5406b79d2cf899425ff4
https://doi.org/10.1042/bcj20190577
https://doi.org/10.1042/bcj20190577
Autor:
Sergei Laktyushin, Amir A. Kiamov
Publikováno v:
2021 IEEE Conference of Russian Young Researchers in Electrical and Electronic Engineering (ElConRus).
The purpose of this study is to study the methods and principles of cryptographic systems that have the property of homomorphism, that is, they are capable of performing various operations with encrypted data without decrypting them. As an experiment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a5c0410c49c200c7a93fc2a92ea7cb7
https://doi.org/10.1109/elconrus51938.2021.9396570
https://doi.org/10.1109/elconrus51938.2021.9396570
Publikováno v:
CAD/EDA, MODELING AND SIMULATION IN MODERN ELECTRONICS: COLLECTION OF SCIENTIFIC PAPERS OF THE III INTERNATIONAL SCIENTIFIC AND PRACTICAL CONFERENCE.
When planning a communication network, the main task is to collect the necessary information about the various components of the network and their influence on the degradation of speech quality. The results of simulation and analytical modeling the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61f84b02771700e9966879e3d9891920
https://doi.org/10.30987/conferencearticle_5e0282137973f7.43595815
https://doi.org/10.30987/conferencearticle_5e0282137973f7.43595815