Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lakshya Bajaj"'
Autor:
Jaiprakash Sharma, Shalaka Mulherkar, Uan-I Chen, Yan Xiong, Lakshya Bajaj, Byoung-Kyu Cho, Young Ah Goo, Hon-Chiu Eastwood Leung, Kimberley F. Tolias, Marco Sardiello
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-19 (2023)
Abstract Calpains are a class of non-lysosomal cysteine proteases that exert their regulatory functions via limited proteolysis of their substrates. Similar to the lysosomal and proteasomal systems, calpain dysregulation is implicated in the pathogen
Externí odkaz:
https://doaj.org/article/935902bca75149fd879e892dfdad739a
Autor:
Michela Palmieri, Rituraj Pal, Hemanth R. Nelvagal, Parisa Lotfi, Gary R. Stinnett, Michelle L. Seymour, Arindam Chaudhury, Lakshya Bajaj, Vitaliy V. Bondar, Laura Bremner, Usama Saleem, Dennis Y. Tse, Deepthi Sanagasetti, Samuel M. Wu, Joel R. Neilson, Fred A. Pereira, Robia G. Pautler, George G. Rodney, Jonathan D. Cooper, Marco Sardiello
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
The transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis. Here authors show that trehalose, an mTOR-independent autophagy inducer, alleviates the pathological phenotypes in a mouse model of neurodegenerative disease. Trehalose
Externí odkaz:
https://doaj.org/article/9d01b8cdb7714197a5184f986c9a6f8a
Autor:
Michela Palmieri, Rituraj Pal, Hemanth R. Nelvagal, Parisa Lotfi, Gary R. Stinnett, Michelle L. Seymour, Arindam Chaudhury, Lakshya Bajaj, Vitaliy V. Bondar, Laura Bremner, Usama Saleem, Dennis Y. Tse, Deepthi Sanagasetti, Samuel M. Wu, Joel R. Neilson, Fred A. Pereira, Robia G. Pautler, George G. Rodney, Jonathan D. Cooper, Marco Sardiello
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-3 (2017)
Nature Communications 8: Article number: 14338 (2017); Published: 6 February 2017; Updated: 13 June 2017 This Article contains errors in Figs 2 and 3, for which we apologize. In Fig. 2c, the four images were inadvertently duplicated from the images i
Externí odkaz:
https://doaj.org/article/ad88932b47944958b842a6eaf7d2a132
Autor:
Anne E. Dodson, Brandon D. Fields, Daniel J. Pagano, Yuhan Fei, Scott Kennedy, Gang Wan, Lakshya Bajaj
Publikováno v:
EMBO J
Germ granules are biomolecular condensates that form in germ cells of all/most animals, where they regulate mRNA expression to promote germ cell function and totipotency. In the adult Caenorhabditis elegans germ cell, these granules are composed of a
Autor:
Alberto di Ronza, Lakshya Bajaj, Marco Sardiello, Parisa Lotfi, Jaiprakash Sharma, Rituraj Pal
Publikováno v:
Journal of Neurochemistry. 148:573-589
This review focuses on the pathways that regulate lysosome biogenesis and that are implicated in numerous degenerative storage diseases, including lysosomal storage disorders and late-onset neurodegenerative diseases. Lysosomal proteins are synthesiz
Autor:
Marco Sardiello, Ying-Wooi Wan, John Q. Trojanowski, Virginia M.-Y. Lee, Lakshya Bajaj, Allysa L. Cole, Dan B. Swartzlander, Fading Chen, Hui Zheng, David A. Bader, Zhandong Liu, Heidi Martini-Stoica
Publikováno v:
The Journal of Experimental Medicine
Martini-Stoica et al. demonstrate that the TFEB-mediated lysosomal pathway in astrocytes is increased in tauopathy and plays a functional role in modulating extracellular tau and the propagation of neuronal tau pathology in a mouse model of tau sprea
Autor:
Marco Sardiello, Rui Chen, Alberto di Ronza, John R. Collette, Aiden Eblimit, Jaiprakash Sharma, Dany Roman, Sung Yun Jung, Richard N. Sifers, Randy Schekman, Lakshya Bajaj, Rituraj Pal, Pengcheng Zheng
Lysosomal enzymes are synthesized in the endoplasmic reticulum (ER) and transferred to the Golgi complex by interaction with the Batten disease protein CLN8. Here we investigated the relationship of this pathway with CLN6, an ER-associated protein of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27a285efc053b8bea8f283b8e78db39
Autor:
Alberto di Ronza, Pengcheng Zhang, Lakshya Bajaj, Dany Roman, Rituraj Pal, Sung Yun Jung, Jill M. Weimer, Jaiprakash Sharma, Rui Chen, Marco Sardiello, Richard N. Sifers, Randy Schekman, John R. Collette, Aiden Eblimit, Clarissa D. Booth, Kevin T. Chang
Publikováno v:
J Clin Invest
Lysosomal enzymes are synthesized in the endoplasmic reticulum (ER) and transferred to the Golgi complex by interaction with the Batten disease protein CLN8 (ceroid lipofuscinosis, neuronal, 8). Here we investigated the relationship of this pathway w
Autor:
Usama Saleem, Arindam Chaudhury, Fred A. Pereira, Michelle L. Seymour, Hemanth R. Nelvagal, Vitaliy V. Bondar, Parisa Lotfi, Gary R. Stinnett, Marco Sardiello, Samuel M. Wu, Laura Bremner, Lakshya Bajaj, George G. Rodney, Deepthi Sanagasetti, Rituraj Pal, Michela Palmieri, Joel R. Neilson, Dennis Y. Tse, Robia G. Pautler, Jonathan D. Cooper
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-3 (2017)
Nature Communications 8: Article number: 14338 (2017); Published: 6 February 2017; Updated: 13 June 2017 This Article contains errors in Figs 2 and 3, for which we apologize. In Fig. 2c, the four images were inadvertently duplicated from the images i
Autor:
Parisa Lotfi, Laura Segatori, Carolyn J. Adamski, Jaiprakash Sharma, Alessandro Simonati, Filippo M. Santorelli, Richard N. Sifers, Maria Chiara Meschini, Marco Sardiello, Lakshya Bajaj, Lauren Popp, Hon Chiu Eastwood Leung, Deepthi Sanagasetti, Kevin T. Chang, John R. Collette, Alberto di Ronza, Michela Palmieri, Abdallah Amawi
Publikováno v:
Nature cell biology
Organelle biogenesis requires proper transport of proteins from their site of synthesis to their target subcellular compartment1–3. Lysosomal enzymes are synthesized in the endoplasmic reticulum (ER) and traffic through the Golgi complex before bei