Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians

Autor: Wang, Minxian, Menon, Ramesh, Mishra, Sanghamitra, Patel, Aniruddh P, Chaffin, Mark, Tanneeru, Deepak, Deshmukh, Manjari, Mathew, Oshin, Apte, Sanika, Devanboo, Christina S, Sundaram, Sumathi, Lakshmipathy, Praveena, Murugan, Sakthivel, Sharma, Krishna Kumar, Rajendran, Karthikeyan, Santhosh, Sam, Thachathodiyl, Rajesh, Ahamed, Hisham, Balegadde, Aniketh Vijay, Alexander, Thomas, Swaminathan, Krishnan, Gupta, Rajeev, Mullasari, Ajit S, Sigamani, Alben, Kanchi, Muralidhar, Peterson, Andrew S, Butterworth, Adam S, Danesh, John, Di Angelantonio, Emanuele, Naheed, Aliya, Inouye, Michael, Chowdhury, Rajiv, Vedam, Ramprasad L, Kathiresan, Sekar, Gupta, Ravi, Khera, Amit V

BACKGROUND: Genome-wide polygenic scores (GPS) integrate information from many common DNA variants into a single number. Because rates of coronary artery disease (CAD) are substantially higher among South Asians, a GPS to identify high-risk individua

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Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians.

Autor: Wang M; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Menon R; MedGenome Labs Ltd., Bengaluru, India., Mishra S; MedGenome Labs Ltd., Bengaluru, India., Patel AP; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts., Chaffin M; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Tanneeru D; MedGenome Labs Ltd., Bengaluru, India., Deshmukh M; MedGenome Labs Ltd., Bengaluru, India., Mathew O; MedGenome Labs Ltd., Bengaluru, India., Apte S; MedGenome Labs Ltd., Bengaluru, India., Devanboo CS; MedGenome Labs Ltd., Bengaluru, India., Sundaram S; MedGenome Labs Ltd., Bengaluru, India., Lakshmipathy P; MedGenome Labs Ltd., Bengaluru, India., Murugan S; MedGenome Labs Ltd., Bengaluru, India., Sharma KK; Eternal Heart Care Centre, Jaipur, India., Rajendran K; Narayana Health, Bengaluru, India., Santhosh S; MedGenome Labs Ltd., Bengaluru, India., Thachathodiyl R; Amrita Institute Medical Sciences, Kochi, India., Ahamed H; Amrita Institute Medical Sciences, Kochi, India., Balegadde AV; Amrita Institute Medical Sciences, Kochi, India., Alexander T; Kovai Medical Center and Hospital Research Foundation, Coimbatore, India., Swaminathan K; Kovai Medical Center and Hospital Research Foundation, Coimbatore, India., Gupta R; Eternal Heart Care Centre, Jaipur, India., Mullasari AS; Madras Medical Mission, Chennai, India., Sigamani A; Narayana Health, Bengaluru, India., Kanchi M; Narayana Health, Bengaluru, India., Peterson AS; MedGenome Inc., Foster City, California., Butterworth AS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom., Danesh J; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, United Kingdom; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, United Kingdom; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, United Kingdom., Di Angelantonio E; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom., Naheed A; International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh., Inouye M; Cambridge Baker Systems Genomics Initiative, Melbourne, Victoria, Australia, and Cambridge, United Kingdom; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Department of Clinical Pathology and School of BioSciences, University of Melbourne, Parkville, Victoria, Australia; The Alan Turing Institute, London, United Kingdom., Chowdhury R; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Centre for Non-Communicable Disease Research, Dhaka, Bangladesh., Vedam RL; MedGenome Labs Ltd., Bengaluru, India., Kathiresan S; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts; Verve Therapeutics, Cambridge, Massachusetts., Gupta R; MedGenome Labs Ltd., Bengaluru, India., Khera AV; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts. Electronic address: avkhera@mgh.harvard.edu.

Publikováno v: Journal of the American College of Cardiology [J Am Coll Cardiol] 2020 Aug 11; Vol. 76 (6), pp. 703-714.