Zobrazeno 1 - 10
of 564
pro vyhledávání: '"Lakshminarayan M"'
Autor:
Taylor M. Gerson, Audrey M. Ott, Monika M. A. Karney, Jillian N. Socea, Daren R. Ginete, Lakshminarayan M. Iyer, L. Aravind, Ronald K. Gary, Helen J. Wing
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT The VirB protein, encoded by the large virulence plasmid of Shigella spp., is a key transcriptional regulator of virulence genes. Without virB, Shigella cells are avirulent. On the virulence plasmid, VirB functions to offset transcriptional
Externí odkaz:
https://doaj.org/article/fc3cc248550549869b8473588cb9be2a
Publikováno v:
Viruses, Vol 14, Iss 9, p 1977 (2022)
NAD+ and ADP-ribose (ADPr)-containing molecules are at the interface of virus–host conflicts across life encompassing RNA processing, restriction, lysogeny/dormancy and functional hijacking. We objectively defined the central components of the NAD+
Externí odkaz:
https://doaj.org/article/88c3f7e83c424f6c8aa83d93f521896c
Publikováno v:
eLife, Vol 10 (2021)
Several homologous domains are shared by eukaryotic immunity and programmed cell-death systems and poorly understood bacterial proteins. Recent studies show these to be components of a network of highly regulated systems connecting apoptotic processe
Externí odkaz:
https://doaj.org/article/c54f39a734f74d12b4fc619c2cc36e8f
Publikováno v:
iScience, Vol 9, Iss , Pp 192-208 (2018)
Summary: The provenance of several components of major uniquely eukaryotic molecular machines are increasingly being traced back to prokaryotic biological conflict systems. Here, we demonstrate that the N-terminal single-stranded DNA-binding domain f
Externí odkaz:
https://doaj.org/article/75e971a5937c4a4ca332a6cda8e74af6
Autor:
Samuel H. Becker, Kathrin Ulrich, Avantika Dhabaria, Beatrix Ueberheide, William Beavers, Eric P. Skaar, Lakshminarayan M. Iyer, L. Aravind, Ursula Jakob, K. Heran Darwin
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT The bacterial pathogen Mycobacterium tuberculosis is the leading cause of death by an infectious disease among humans. Here, we describe a previously uncharacterized M. tuberculosis protein, Rv0991c, as a molecular chaperone that is activate
Externí odkaz:
https://doaj.org/article/f5ea186d359e44bc9800d53283f1b1a1
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
The origin of eukaryotes was marked by the emergence of several novel subcellular systems. One such is the calcium (Ca2+)-stores system of the endoplasmic reticulum, which profoundly influences diverse aspects of cellular function including signal tr
Externí odkaz:
https://doaj.org/article/8740205a119049539d304753d89460d9
Autor:
Blair Armistead, Christopher Whidbey, Lakshminarayan M. Iyer, Pilar Herrero-Foncubierta, Phoenicia Quach, Ali Haidour, L. Aravind, Juan Manuel Cuerva, Heather B. Jaspan, Lakshmi Rajagopal
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/86c7d39d7b9345cab82a38a03e4dfe57
Publikováno v:
eLife, Vol 9 (2020)
Social cellular aggregation or multicellular organization pose increased risk of transmission of infections through the system upon infection of a single cell. The generality of the evolutionary responses to this outside of Metazoa remains unclear. W
Externí odkaz:
https://doaj.org/article/a0f90e4cb6064018b52010f1844631b0
Autor:
Blair Armistead, Christopher Whidbey, Lakshminarayan M. Iyer, Pilar Herrero-Foncubierta, Phoenicia Quach, Ali Haidour, L. Aravind, Juan Manuel Cuerva, Heather B. Jaspan, Lakshmi Rajagopal
Publikováno v:
Frontiers in Microbiology, Vol 10 (2020)
Group B Streptococcus (GBS) is a β-hemolytic, Gram-positive bacterium that commonly colonizes the female lower genital tract and is associated with fetal injury, preterm birth, spontaneous abortion, and neonatal infections. A major factor promoting
Externí odkaz:
https://doaj.org/article/43297c6a1da04a239382aa921484f999
Autor:
Lakshminarayan M. Iyer, Vivek Anantharaman, Arunkumar Krishnan, A. Maxwell Burroughs, L. Aravind
Publikováno v:
Viruses, Vol 13, Iss 1, p 63 (2021)
Jumbo phages have attracted much attention by virtue of their extraordinary genome size and unusual aspects of biology. By performing a comparative genomics analysis of 224 jumbo phages, we suggest an objective inclusion criterion based on genome siz
Externí odkaz:
https://doaj.org/article/4334188b47ed4d62bde09055c30c3722