Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Lakshmi Santhanam"'
Autor:
Zechariah G. Franks, Kavitha Nandakumar, Lakshmi Santhanam, Laeben Lester, Jonathan M. Walsh, Nicholas M. Dalesio
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 9, Iss 1, Pp n/a-n/a (2024)
Abstract Objective To investigate differences in angiotensin‐converting‐enzyme‐2 (ACE2) and bitter taste receptor (TAS2R38) expression between patient age groups and comorbidities to characterize the pathophysiology of coronavirus 19(COVID‐19
Externí odkaz:
https://doaj.org/article/21bd9c81a96f425592488d0f950acd9c
Autor:
Rira Choi, Roshini Narayanan, Sandeep Jandu, William Savage, Sara Kang, Bulouere Wodu, Kavitha Nandakumar, Lakshmi Santhanam, Jochen Steppan
Publikováno v:
Physiological Reports, Vol 12, Iss 1, Pp n/a-n/a (2024)
Abstract Wire myography to test vasomotor functions of blood vessels ex‐vivo are well‐established for the systemic circulation, however, there is no consensus on protocols for pulmonary arteries. We created a standardized wire myography protocol
Externí odkaz:
https://doaj.org/article/4a8feeadd1064cd6865d1f8f01335e90
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
A role for Factor Xa in the proteolytic processing of LOXL2 is identified and the resulting processed LOXL2 changes affinity from collagen IV to collagen I and increasingly binds to LOX, suggesting that LOX could be recruited to the regions where cle
Externí odkaz:
https://doaj.org/article/db0c8591b96e48039068fa7208b99719
Autor:
Kei Akiyoshi, Tomonari Fujimori, Xiuping Fu, Aparna P. Shah, Atsushi Yamaguchi, Charles Steenbergen, Lakshmi Santhanam, Dan Berkowitz, Eric Tuday, Jay M. Baraban, Samarjit Das
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 14 (2023)
Background The identification of large‐artery stiffness as a major, independent risk factor for cardiovascular disease–associated morbidity and death has focused attention on identifying therapeutic strategies to combat this disorder. Genetic man
Externí odkaz:
https://doaj.org/article/a71419da408847be91b663d9bf83fc75
Autor:
Jochen Steppan, Kavitha Nandakumar, Huilei Wang, Rosie Jang, Logan Smith, Sara Kang, William Savage, Maria Bauer, Rira Choi, Travis Brady, Bulouere Princess Wodu, Susanna Scafidi, Joseph Scafidi, Lakshmi Santhanam
Publikováno v:
Physiological Reports, Vol 11, Iss 7, Pp n/a-n/a (2023)
Abstract Hypoxia in the neonatal period is associated with early manifestations of adverse cardiovascular health in adulthood including higher risk of hypertension and atherosclerosis. We hypothesize that this occurs due to activation of lysyl oxidas
Externí odkaz:
https://doaj.org/article/9fe5f4f1fd4f4d71968c9b6b4ce21315
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 2, Pp n/a-n/a (2023)
Abstract Pulmonary arterial hypertension (PAH) is more prevalent in females than males; the causes of this sex difference have not been adequately explored. Gain‐of‐function (GOF) mutations in hypoxia‐inducible factor 2α (HIF2A) lead to PAH an
Externí odkaz:
https://doaj.org/article/31d97831abae4b3caf2516ac6c24b8fb
Autor:
Nicolas Philip, Hongyang Pi, Mahin Gadkari, Xin Yun, John Huetsch, Cissy Zhang, Robert Harlan, Aurelie Roux, David Graham, Larissa Shimoda, Anne Le, Scott Visovatti, Peter J. Leary, Sina A. Gharib, Catherine Simpson, Lakshmi Santhanam, Jochen Steppan, Karthik Suresh
Publikováno v:
Pulmonary Circulation, Vol 13, Iss 1, Pp n/a-n/a (2023)
Abstract In pulmonary artery hypertension (PAH), emerging evidence suggests that metabolic abnormalities may be contributing to cellular dysfunction in PAH. Metabolic abnormalities such as glycolytic shift have been observed intracellularly in severa
Externí odkaz:
https://doaj.org/article/97025afab3c44d04bea6835abb15b53e
Autor:
Huilei Wang, James Chen, Sandeep Jandu, Sean Melucci, William Savage, Kavitha Nandakumar, Sara K. Kang, Sebastian Barreto-Ortiz, Alan Poe, Shivam Rastogi, Maria Bauer, Jochen Steppan, Lakshmi Santhanam
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract Tissue transglutaminase (TG2), a multifunctional protein of the transglutaminase family, has putative transamidation-independent functions in aging-associated vascular stiffening and dysfunction. Developing preclinical models will be critica
Externí odkaz:
https://doaj.org/article/e5d70fa9ab5a4776b88454e4bd9e5c23
Autor:
Huilei Wang, Alan Poe, Lydia Pak, Kavitha Nandakumar, Sandeep Jandu, Jochen Steppan, Reik Löser, Lakshmi Santhanam
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
To address the limitation of inability to detect lysyl oxidase enzymes (LOX) catalytic function associated with diverse disease processes, Wang et al. developed an in situ activity assay by utilizing the reactivity of hydrazides with imines and carbo
Externí odkaz:
https://doaj.org/article/226aeaa38a774c2ebbf2d0e380dfffce
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/7fcbdc62d3c74310ba7a2ade5ec2a7c1