Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Lakshmi Muthuswamy"'
Autor:
Nhu-An Pham, Nikolina Radulovich, Emin Ibrahimov, Sebastiao N. Martins-Filho, Quan Li, Melania Pintilie, Jessica Weiss, Vibha Raghavan, Michael Cabanero, Robert E. Denroche, Julie M. Wilson, Cristiane Metran-Nascente, Ayelet Borgida, Shawn Hutchinson, Anna Dodd, Michael Begora, Dianne Chadwick, Stefano Serra, Jennifer J. Knox, Steven Gallinger, David W. Hedley, Lakshmi Muthuswamy, Ming-Sound Tsao
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Patient-derived xenograft (PDX) and their xenograft-derived organoid (XDO) models that recapitulate the genotypic and phenotypic landscape of patient cancers could help to advance research and lead to improved clinical management. PDX models
Externí odkaz:
https://doaj.org/article/a748f950b73d4012ad6cf5ca93a0e308
Autor:
Manuel Hidalgo, Senthil K. Muthuswamy, Mark Callery, Tara S. Kent, Martin Smith, Tyler M. Berzin, Douglas Pleskow, Mandeep S. Sawhney, Robert Besaw, Roger B. Davis, Christine Lim, Supraja Narasimhan, Catherine Conahan, Mary Linton B. Peters, Benjamin Schlechter, Andrea J. Bullock, Bruno Bockorny, Jonah Cohen, Leo L. Tsai, Raul S. Gonzalez, Sofia Perea, Dipikaa Akshinthala, Ling Huang, Lakshmi Muthuswamy, Joseph E. Grossman
Supplementary Data from Organoid Sensitivity Correlates with Therapeutic Response in Patients with Pancreatic Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1260fc09a1c2717a2c1423956de7284d
https://doi.org/10.1158/1078-0432.22484078
https://doi.org/10.1158/1078-0432.22484078
Autor:
Manuel Hidalgo, Senthil K. Muthuswamy, Mark Callery, Tara S. Kent, Martin Smith, Tyler M. Berzin, Douglas Pleskow, Mandeep S. Sawhney, Robert Besaw, Roger B. Davis, Christine Lim, Supraja Narasimhan, Catherine Conahan, Mary Linton B. Peters, Benjamin Schlechter, Andrea J. Bullock, Bruno Bockorny, Jonah Cohen, Leo L. Tsai, Raul S. Gonzalez, Sofia Perea, Dipikaa Akshinthala, Ling Huang, Lakshmi Muthuswamy, Joseph E. Grossman
Purpose:Pancreatic ductal adenocarcinoma (PDAC) remains a significant health issue. For most patients, there are no options for targeted therapy, and existing treatments are limited by toxicity. The HOPE trial (Harnessing Organoids for PErsonalized T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c2c3cab84e98173ebbc1888ec47fd08
https://doi.org/10.1158/1078-0432.c.6531320
https://doi.org/10.1158/1078-0432.c.6531320
Autor:
Bruno Bockorny, Lakshmi Muthuswamy, Ling Huang, Marco Hadisurya, Christine Maria Lim, Leo L. Tsai, Ritu R. Gill, Jesse L. Wei, Andrea J. Bullock, Joseph E. Grossman, Robert J. Besaw, Supraja Narasimhan, W. Andy Tao, Sofia Perea, Mandeep S. Sawhney, Steven D. Freedman, Manuel Hidalgo, Anton Iliuk, Senthil K. Muthuswamy
Publikováno v:
medRxiv
Pancreatic cancer has the worst prognosis of all common tumors. Earlier cancer diagnosis could increase survival rates and better assessment of metastatic disease could improve patient care. As such, there is an urgent need to develop biomarkers to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be9a56795ec8bd6bfdbbb0483831de1
https://doi.org/10.1101/2023.03.13.23287216
https://doi.org/10.1101/2023.03.13.23287216
Autor:
Lakshmi Muthuswamy, Ling Huang, Raul S. Gonzalez, Jonah Cohen, Senthil K. Muthuswamy, Catherine Conahan, Supraja Narasimhan, Tyler M. Berzin, Mandeep S. Sawhney, Andrea J. Bullock, Mary Linton B. Peters, Sofia Perea, Roger B. Davis, Benjamin Schlechter, Bruno Bockorny, Dipikaa Akshinthala, Robert J. Besaw, Mark P. Callery, Douglas K. Pleskow, Leo L. Tsai, Martin P. Smith, Christine Maria Lim, Manuel Hidalgo, Tara S. Kent, Joseph E. Grossman
Publikováno v:
Clin Cancer Res
Purpose: Pancreatic ductal adenocarcinoma (PDAC) remains a significant health issue. For most patients, there are no options for targeted therapy, and existing treatments are limited by toxicity. The HOPE trial (Harnessing Organoids for PErsonalized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a528f7d154a6854e7926499da596a9af
https://doi.org/10.1158/1078-0432.ccr-20-4116
https://doi.org/10.1158/1078-0432.ccr-20-4116
Autor:
Shawn Hutchinson, Jessica Weiss, Ming-Sound Tsao, Lakshmi Muthuswamy, Sebastiao N. Martins-Filho, David W. Hedley, Nikolina Radulovich, Michael Cabanero, Steven Gallinger, Emin Ibrahimov, Nhu-An Pham, Jennifer J. Knox, Julie M. Wilson, Robert E. Denroche, Cristiane Metran-Nascente, Michael Begora, Dianne Chadwick, Melania Pintilie, Stefano Serra, Quan Li, Vibha Raghavan, Anna Dodd, Ayelet Borgida
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Patient-derived xenograft (PDX) and their xenograft-derived organoid (XDO) models that recapitulate the genotypic and phenotypic landscape of patient cancers could help to advance research and lead to improved clinical management. PDX models were est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3769c8d1aeb392bf740b37078270d8a3
https://doaj.org/article/a748f950b73d4012ad6cf5ca93a0e308
https://doaj.org/article/a748f950b73d4012ad6cf5ca93a0e308
Autor:
Senthil K. Muthuswamy, Steven D. Freedman, Andrew Emili, George G. Daaboul, Omar Gandarilla, Sofia Perea Del Pino, Sylvain Lehoux, Veronica Sanchez-Gonzalez, Emily E Rouse, Lakshmi Muthuswamy, Joseph Grossman, Dipikaa Akshinthala, John G. Clohessy, Ling Huang, Arindam Bose, Nicole Pandell, Christine Maria Lim, Manuel Hidalgo, Alexander Kleger, Bruno Bockorny, Richard D. Cummings, Raul S. Gonzalez, Pierre-Oliver Frappart, Mandeep S. Sawhney, Indranil Paul
Publikováno v:
JCI Insight, Vol 5, Iss 21 (2020)
JCI Insight
JCI Insight
Patient-derived organoid models are proving to be a powerful platform for both basic and translational studies. Here we conduct a methodical analysis of pancreatic ductal adenocarcinoma (PDAC) tumor organoid drug response in paired patient-derived xe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00487f403ddf096485243ae6bd50244
https://doi.org/10.1172/jci.insight.135544
https://doi.org/10.1172/jci.insight.135544
Autor:
Bruno Bockorny, Lakshmi Muthuswamy, Ling Huang, Marco Hadisurya, Leo Tsai, Ritu R. Gill, Jesse Wei, Andrea J. Bullock, Joseph Elan Grossman, Robert J. Besaw, Christine Maria Lim, Supraja Narasimhan, Sofia Perea, Mandeep Sawhney, W. Andy Tao, Steven Freedman, Manuel Hidalgo, Anton Iliuk, Senthil Muthuswamy
Publikováno v:
Journal of Clinical Oncology. 40:523-523
523 Background: Robust biomarkers are urgently needed to assist in diagnosing pancreatic cancer. Earlier cancer diagnosis could increase survival rates by an estimated 5-fold and more reliable and real-time assessment of treatment effects in patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::def9fd824b4d06913f43fe4e147f38ba
https://doi.org/10.1200/jco.2022.40.4_suppl.523
https://doi.org/10.1200/jco.2022.40.4_suppl.523
Autor:
Ridhdhi R. Desai, Nayara C. Leite, Ling Huang, Daniel N. Conrad, Dipikaa Akshinthala, Raul S. Gonzalez, Lakshmi Muthuswamy, Christine Maria Lim, Senthil K. Muthuswamy, Zev J. Gartner
Publikováno v:
Cell Stem Cell. 28:1090-1104.e6
Summary The exocrine pancreas, consisting of ducts and acini, is the site of origin of pancreatitis and pancreatic ductal adenocarcinoma (PDAC). Our understanding of the genesis and progression of human pancreatic diseases, including PDAC, is limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6a40a74c377d6a5f3140683ac835050
https://doi.org/10.1016/j.stem.2021.03.022
https://doi.org/10.1016/j.stem.2021.03.022
Autor:
Sofia Perea Del Pino, Emily E Rouse, Ling Huang, John G. Clohessy, Omar Gandarilla, Senthil K. Muthuswamy, Veronica Sanchez-Gonzalez, Andrew Emili, Joseph Grossman, Manuel Hidalgo, Dipikaa Akshinthala, Arindam Bose, Raul S. Gonzalez, Lakshmi Muthuswamy, Mandeep S. Sawhney, Indranil Paul, George G. Daaboul, Steven D. Freedman, Nicole Pandell, Bruno Bockorny, Richard D. Cummings, Sylvain Lehoux
Patient-derived models are transforming translational cancer research. It is not clear if the emergence of patient-derived organoid (PDO) models can extend the utility of the widely used patient-derived xenograft (PDX). In addition, the utility of PD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91793f2dfb6bb000937a5337ba422e8
https://doi.org/10.1101/513267
https://doi.org/10.1101/513267