Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lakshmi Maganti"'
Autor:
Rakesh Kumar Mishra, Lakshmi Maganti
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 40:11373-11382
Denaturation of the DNA double helix inside the cell is essential for cellular processes such as replication and transcription for the growth of the cells. However, the growth of unwanted cells, which are responsible for cancerous kind of disease, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c74bf4af9182371ce0cdcd0e881b4fd
https://doi.org/10.1080/07391102.2021.1960193
https://doi.org/10.1080/07391102.2021.1960193
Autor:
Chandrayee Mukherjee, Duhita Sengupta, Lakshmi Maganti, M. Mahendar, Dhananjay Bhattacharyya, Kaushik Sengupta
Publikováno v:
RSC advances. 12(49)
Lamins maintain the shape and rigidity of the nucleus in the form of a proteinaceous scaffold underneath the inner nuclear membrane (INM) and provide anchorage to chromatin and other nuclear proteins. Mutations in the human LMNA gene encoding lamin A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc7969a29e26c0f072c74abae5af4ab
https://pubmed.ncbi.nlm.nih.gov/36415558
https://pubmed.ncbi.nlm.nih.gov/36415558
Autor:
Chandrayee Mukherjee, Duhita Sengupta, Lakshmi Maganti, M. Mahendar, Dhananjay Bhattacharyya, Kaushik Sengupta
Lamins maintain the shape and rigidity of the nucleus in the form of a proteinaceous scaffold underneath the inner nuclear membrane (INM) and provide anchorage to chromatin and other nuclear proteins. Mutations in the human LMNA gene encoding lamin A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7e18b17d75f44ddda4291e7233cccde
https://doi.org/10.1101/2022.01.27.478013
https://doi.org/10.1101/2022.01.27.478013
Publikováno v:
Journal of Biomolecular Structure and Dynamics
Here, we study microscopic mechanism of complex formation between Ca2+-bound calmodulin (holoCaM) and Orai1 that regulates Ca2+-dependent inactivation process in eukaryotic cells. We compute conformational thermodynamic changes in holoCaM with respec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90196c48ab4ed8d1d6e03dfb438617b8
Publikováno v:
BiopolymersREFERENCES. 111(10)
Restriction endonucleases protect bacterial cells against bacteriophage infection by cleaving the incoming foreign DNA into fragments. In presence of Mg2+ ions, EcoRV is able to cleave the DNA but not in presence of Ca2+ , although the protein binds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277b4df439c4597942e6aea78dea7a47
https://pubmed.ncbi.nlm.nih.gov/32858776
https://pubmed.ncbi.nlm.nih.gov/32858776
Publikováno v:
Journal of computer-aided molecular design. 34(1)
DNA is an essential target for the treatment of various pathologies, especially cancer. Hence targeting DNA double helix for alteration of its function has been attempted by several ways. Drug-DNA intercalation, one such biophysical process, could no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d28daabccf251ee353956d1ef67fd5
https://pubmed.ncbi.nlm.nih.gov/31820194
https://pubmed.ncbi.nlm.nih.gov/31820194
Autor:
Kaushik Sengupta, Subarna Dutta, J. K. Das, Maitree Bhattacharyya, Sujoy Mukherjee, Dhananjay Bhattacharyya, Lakshmi Maganti
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Mutations in the different domains of A-type lamin proteins cause a diverse plethora of diseases collectively termed as laminopathies which can affect multiple organs. Ig fold is one such domain of lamin A which is implicated in numerous nuclear inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40baff1149092f8c876727013b8c59d8
https://doi.org/10.1038/s41598-018-32227-2
https://doi.org/10.1038/s41598-018-32227-2
Autor:
Nanda Ghoshal, Lakshmi Maganti
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 33:344-364
Mycobacterium tuberculosis, the pathogen responsible for tuberculosis, uses various strategies to survive in a variety of host lesions. The re-emergence of multi-drug-resistant strains of M. tuberculosis underlines the necessity to discover new molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0e8aef1630dce13ab466cd0f679ad4
https://doi.org/10.1080/07391102.2013.872052
https://doi.org/10.1080/07391102.2013.872052
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 32:273-288
Multidrug resistance capacity of Mycobacterium tuberculosis demands urgent need for developing new antitubercular drugs. The present work is on M. tuberculosis-MbtA, an enzyme involved in the biosynthesis of siderophores, having a critical role in ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192f6a128bfabcec872a94c83119fc78
https://doi.org/10.1080/07391102.2012.762752
https://doi.org/10.1080/07391102.2012.762752
Molecular understanding of bio-macromolecular binding is a challenging task due to large sizes of the molecules and presence of variety of interactions. Here, we study the molecular mechanism of calmodulin (CaM) binding to Orai1 that regulates Ca2+-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4609d070d3934c9b593b72f19496520