Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Lakshmi B. Potluri"'
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Akademický článek
Dysregulated APOBEC3G causes DNA damage and promotes genomic instability in multiple myeloma
Autor: Srikanth Talluri, Mehmet K. Samur, Leutz Buon, Subodh Kumar, Lakshmi B. Potluri, Jialan Shi, Rao H. Prabhala, Masood A. Shammas, Nikhil C. Munshi
Publikováno v: Blood Cancer Journal, Vol 11, Iss 10, Pp 1-11 (2021)
Abstract Multiple myeloma (MM) is a heterogeneous disease characterized by significant genomic instability. Recently, a causal role for the AID/APOBEC deaminases in inducing somatic mutations in myeloma has been reported. We have identified APOBEC/AI
Externí odkaz: https://doaj.org/article/d13895ee298b46c692921d6655cf5d13
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4
ABL1 Kinase plays an important role in spontaneous and chemotherapy-induced genomic instability in multiple myeloma
Autor: Subodh Kumar, Srikanth Talluri, Jiangning Zhao, Chengcheng Liao, Lakshmi B. Potluri, Leutz Buon, Shidai Mu, Jialan Shi, Chandraditya Chakraborty, Yu-Tzu Tai, Mehmet K. Samur, Masood A. Shammas, Nikhil C. Munshi
Genomic instability contributes to cancer progression and is at least partly due to dysregulated homologous recombination. Here, we show that an elevated level of ABL1 kinase overactivates the HR pathway and causes genomic instability in multiple mye
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2e61bb7108900da5a003b644b297d1d
https://doi.org/10.1101/2022.05.12.491727
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5
Dysregulated APOBEC3G causes DNA damage and promotes genomic instability in multiple myeloma
Autor: Subodh Kumar, Rao Prabhala, Jialan Shi, Masood A. Shammas, Lakshmi B. Potluri, Srikanth Talluri, Leutz Buon, Nikhil C. Munshi, Mehmet Kemal Samur
Publikováno v: Blood Cancer Journal, Vol 11, Iss 10, Pp 1-11 (2021)
Blood Cancer Journal
Multiple myeloma (MM) is a heterogeneous disease characterized by significant genomic instability. Recently, a causal role for the AID/APOBEC deaminases in inducing somatic mutations in myeloma has been reported. We have identified APOBEC/AID as a pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef4e07639a1c5c05a9e152a607ffc8d
https://doi.org/10.1038/s41408-021-00554-9
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7
A High Throughput Functional Screen Identifies a Novel Apex Inhibitor: Augments Cytotoxicity While Significantly Decreasing Genomic Evolution in Myeloma
Autor: Nikhil C. Munshi, Srikanth Talluri, Mychell Neptune-Buon, Lakshmi B. Potluri, Masood A. Shammas, Jialan Shi, Subodh Kumar
Publikováno v: Blood. 136:10-11
Multiple myeloma (MM) is molecularly heterogenous disease with significant genomic instability. It carries number of mutations at diagnosis (median > 7000) and acquires additional changes overtime. With this background, we have evaluated the molecula
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d82eaa0f08740569384aeea5a97895d6
https://doi.org/10.1182/blood-2020-139945
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9
Atpase Family AAA Domain-Containing Protein 2 (ATAD2) As a Novel Target in Multiple Myeloma
Autor: Masood A. Shammas, Rao Prabhala, Jialan Shi, Subodh Kumar, Leutz Buon, Anil Aktas-Samur, Mehmet Kemal Samur, Srikanth Talluri, Lakshmi B. Potluri, Chandraditya Chakraborty, Nikhil C. Munshi
Publikováno v: Blood. 136:50-50
Multiple myeloma (MM) is a genomically heterogenous malignancy characterized by a number of copy number alterations (CNA). Moreover, there is a clear evolution of genomic changes that may affect prognosis. To identify the drivers of this inherent gen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27383e30683ca43a142b53cf5c6541c4
https://doi.org/10.1182/blood-2020-140466
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10
Ongoing Spontaneous DNA Damage Creates Synthetic Lethality Targeted By Novel RAD51 Inhibitors in Multiple Myeloma
Autor: Lakshmi B. Potluri, Kevin Mills, Chandraditya Chakraborty, Nikhil C. Munshi, Subodh Kumar, Maria Gkotzamanidou, Melinda Day, Srikanth Talluri, Masood A. Shammas, Mychell A. Neptune
Publikováno v: Blood. 134:4378-4378
Unrepaired DNA double-strand breaks (DSBs) pose a serious threat to genomic stability, potentially leading to the formation of oncogenic mutations, as well as translocations, deletions and amplifications. Almost all multiple myeloma (MM) patients are
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d139d2ff78b9bdf7538bd6fcb0c4421d
https://doi.org/10.1182/blood-2019-129121
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