Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lakshmi, Kugathasan"'
Autor:
Tayler A. Buchan, MSc, Lakshmi Kugathasan, PhD, Jeremy Kobulnik, MD, Stephanie Poon, MD, Kyle Runeckles, MSc, Steve Fan, PhD, PStat, Heather J. Ross, MD, Ana C. Alba, MD, PhD
Publikováno v:
CJC Open, Vol 4, Iss 9, Pp 772-781 (2022)
Background: Coronavirus disease 2019 (COVID-19) has resulted in a reduction in patients seeking timely consultation for illnesses that are not related to COVID-19. Previously, we reported a decline in the number of emergency department (ED) visits an
Externí odkaz:
https://doaj.org/article/8f9564279f8a458984a1d2218975fa3e
Autor:
Lakshmi Kugathasan, PhD, Troy Francis, MSc, Valeria E. Rac, MD, PhD, Harindra C. Wijeysundera, MD, PhD, Michael McDonald, MD, Heather J. Ross, MD, Ana Carolina Alba, MD, PhD
Publikováno v:
CJC Open, Vol 3, Iss 7, Pp 929-935 (2021)
Background: Multidisciplinary heart failure (HF) clinics decrease hospital admission rates and healthcare use, while improving patient outcomes. To understand the contemporary availability of HF clinics in Ontario, Canada, and the services provided,
Externí odkaz:
https://doaj.org/article/5f625473ddab4a91ad27001faa1bba23
Autor:
Heather J. Ross, Michael McDonald, Ana C. Alba, Valeria E. Rac, Lakshmi Kugathasan, Troy Francis, Harindra C. Wijeysundera
Publikováno v:
CJC Open, Vol 3, Iss 7, Pp 929-935 (2021)
CJC Open
CJC Open
Background: Multidisciplinary heart failure (HF) clinics decrease hospital admission rates and healthcare use, while improving patient outcomes. To understand the contemporary availability of HF clinics in Ontario, Canada, and the services provided,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2d60d6b40c3cbd745be2c3274a8cb0
http://www.sciencedirect.com/science/article/pii/S2589790X21000913
http://www.sciencedirect.com/science/article/pii/S2589790X21000913
Autor:
Andrew C.T. Ha, Ana C. Alba, Alejandro Ochoa, María Inés Sosa Liprandi, Meyer S. Balter, Alvaro Sosa Liprandi, Shyla Gupta, Lakshmi Kugathasan
Publikováno v:
Current problems in cardiology. 46(10)
Cardiac sarcoidosis (CS) with clinical manifestation occurs in about 5-8% of patients with sarcoidosis. CS may be clinically suspected by the presence of ventricular arrhythmia, conduction abnormalities, and heart failure (HF). However, 20%-25% of pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6d2d32d4d910ddb998abcfc50e12fd
https://pubmed.ncbi.nlm.nih.gov/34400001
https://pubmed.ncbi.nlm.nih.gov/34400001
Publikováno v:
Comprehensive Physiology
Pulmonary arterial hypertension (PAH) is a devastating disease that, despite significant advances in medical therapies over the last several decades, continues to have an extremely poor prognosis. Gene therapy is a method to deliver therapeutic genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68df323074d7576557ecabfd6774d0ba
https://doi.org/10.1002/cphy.c120034
https://doi.org/10.1002/cphy.c120034
Publikováno v:
Endothelial Dysfunction and Inflammation ISBN: 9783034601672
Pulmonary arterial hypertension (PAH) is a rare disease caused by functional and structural abnormalities in distal pulmonary arterioles that result in progressive increases in pulmonary vascular resistance, often leading to right heart failure and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40385eb4c02547dd2e71633c6ad36942
https://doi.org/10.1007/978-3-0346-0168-9_5
https://doi.org/10.1007/978-3-0346-0168-9_5
Publikováno v:
Circulation. 118
Introduction: We have demonstrated downregulation in lung Tie2 receptor expression and activity in experimental models of PAH, implicating reduced Tie2 survival signaling in the pathogenesis of this disease. Therefore, we hypothesized that Tie2 defic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac4174adf2034d583b6c39b8e64a5a97
https://doi.org/10.1161/circ.118.suppl_18.s_361-b
https://doi.org/10.1161/circ.118.suppl_18.s_361-b
Autor:
Shaf Keshavjee, Andre E. Dutly, Judy Trogadis, David W. Courtman, Lakshmi Kugathasan, Duncan J. Stewart
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 86(4)
Visualization of the complex lung microvasculature and resolution of its three-dimensional architecture remains a difficult experimental challenge. We present a novel fluorescent microscopy technique to visualize both the normal and diseased pulmonar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f6195bae216c9508129a8831d828ba
https://pubmed.ncbi.nlm.nih.gov/16518405
https://pubmed.ncbi.nlm.nih.gov/16518405
Autor:
Yidan D. Zhao, Andre E. Dutly, Malcolm J. Robb, Lakshmi Kugathasan, Duncan J. Stewart, Yupu Deng, Shaf Keshavjee
Publikováno v:
Chest. 128
Introduction The pulmonary microvasculature, consisting mainly of an endothelial cell (EC) monolayer and scant matrix support, is incompletely muscularized. Thus, the distal pulmonary arterioles may be predisposed to regression on exposure to environ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8efad0c7aecfeedc53421973a0ad038
https://pubmed.ncbi.nlm.nih.gov/16373885
https://pubmed.ncbi.nlm.nih.gov/16373885
Autor:
Lakshmi Kugathasan, Qiuwang Zhang, Yupu Deng, Yidan D. Zhao, Duncan J. Stewart, David W. Courtman
Publikováno v:
Circulation research. 96(4)
Pulmonary arterial hypertension (PAH) is characterized by a progressive increase in pulmonary vascular resistance caused by narrowing and loss of pulmonary microvasculature, which in its late stages becomes refractory to traditional therapies. We hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342837de7346a185dce5b2a49bb69cda
https://pubmed.ncbi.nlm.nih.gov/15692087
https://pubmed.ncbi.nlm.nih.gov/15692087