Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.

Autor: Hawe JS; Institute of Computational Biology, Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München, Neuherberg, Germany.; Department of Informatics, Technical University of Munich, Garching bei München, Germany., Wilson R; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany., Schmid KT; Institute of Computational Biology, Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München, Neuherberg, Germany.; Department of Informatics, Technical University of Munich, Garching bei München, Germany., Zhou L; Lee Kong Chian School of Medicine, Singapore, Singapore., Lakshmanan LN; Lee Kong Chian School of Medicine, Singapore, Singapore., Lehne BC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Kühnel B; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany., Scott WR; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Wielscher M; Department of Epidemiology and Biostatistics, Imperial College London, London, UK., Yew YW; Lee Kong Chian School of Medicine, Singapore, Singapore., Baumbach C; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany., Lee DP; Genome Institute of Singapore, Singapore, Singapore., Marouli E; Centre for Genomic Health, Queen Mary University of London, London, UK.; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Bernard M; Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.; The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., Pfeiffer L; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany., Matías-García PR; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany., Autio MI; Genome Institute of Singapore, Singapore, Singapore.; Cardiovascular Research Institute, National University Health Systems, National University of Singapore, Singapore, Singapore., Bourgeois S; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Herder C; German Center for Diabetes Research (DZD), partner site Düsseldorf, Düsseldorf, Germany.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Karhunen V; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technical University Munich, Munich, Germany., Prokisch H; Institute of Human Genetics, Technical University Munich, Munich, Germany.; Institute of Neurogenomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Rathmann W; German Center for Diabetes Research (DZD), partner site Düsseldorf, Düsseldorf, Germany.; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Roden M; German Center for Diabetes Research (DZD), partner site Düsseldorf, Düsseldorf, Germany.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany., Sebert S; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Department for Genomics of Common Diseases, School of Public Health, Imperial College London, London, UK., Shin J; Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.; The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., Strauch K; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Southall, UK., Tan WLW; Genome Institute of Singapore, Singapore, Singapore., Hauck SM; Research Unit Protein Science, Helmholtz Zentrum München, German Research Centre for Environmental Health, Munich, Germany., Merl-Pham J; Research Unit Protein Science, Helmholtz Zentrum München, German Research Centre for Environmental Health, Munich, Germany., Grallert H; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany., Barbosa EGV; Institute of Computational Biology, Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München, Neuherberg, Germany., Illig T; Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.; Institute for Human Genetics, Hannover Medical School, Hannover, Germany., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany.; German Research Center for Cardiovascular Disease (DZHK), partner site Munich Heart Alliance, Hannover, Germany., Paus T; Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Canada., Pausova Z; Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada.; The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., Deloukas P; Centre for Genomic Health, Queen Mary University of London, London, UK.; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Foo RSY; Genome Institute of Singapore, Singapore, Singapore.; Cardiovascular Research Institute, National University Health Systems, National University of Singapore, Singapore, Singapore., Jarvelin MR; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland., Kooner JS; National Heart and Lung Institute, Imperial College London, London, UK. j.kooner@ic.ac.uk., Loh M; Lee Kong Chian School of Medicine, Singapore, Singapore. marie.loh@ntu.edu.sg.; Department of Epidemiology and Biostatistics, Imperial College London, London, UK. marie.loh@ntu.edu.sg., Heinig M; Institute of Computational Biology, Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München, Neuherberg, Germany. matthias.heinig@helmholtz-muenchen.de.; Department of Informatics, Technical University of Munich, Garching bei München, Germany. matthias.heinig@helmholtz-muenchen.de., Gieger C; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. christian.gieger@helmholtz-muenchen.de.; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany. christian.gieger@helmholtz-muenchen.de., Waldenberger M; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. waldenberger@helmholtz-muenchen.de.; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany. waldenberger@helmholtz-muenchen.de.; German Research Center for Cardiovascular Disease (DZHK), partner site Munich Heart Alliance, Hannover, Germany. waldenberger@helmholtz-muenchen.de., Chambers JC; Lee Kong Chian School of Medicine, Singapore, Singapore. john.chambers@ic.ac.uk.; Department of Epidemiology and Biostatistics, Imperial College London, London, UK. john.chambers@ic.ac.uk.

Publikováno v: Nature genetics [Nat Genet] 2022 Jan; Vol. 54 (1), pp. 18-29. Date of Electronic Publication: 2022 Jan 03.

Clonal expansion of mitochondrial DNA deletions is a private mechanism of aging in long-lived animals.

Autor: Lakshmanan LN; Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland.; Swiss Institute of Bioinformatics, Quartier Sorge - Batiment Genopode, Lausanne, Switzerland., Yee Z; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Ng LF; Ageing Research Laboratory, Science Division, Yale-NUS College, Singapore, Singapore., Gunawan R; Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland.; Swiss Institute of Bioinformatics, Quartier Sorge - Batiment Genopode, Lausanne, Switzerland., Halliwell B; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Gruber J; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Ageing Research Laboratory, Science Division, Yale-NUS College, Singapore, Singapore.

Publikováno v: Aging cell [Aging Cell] 2018 Oct; Vol. 17 (5), pp. e12814. Date of Electronic Publication: 2018 Jul 24.

Are mutagenic non D-loop direct repeat motifs in mitochondrial DNA under a negative selection pressure?

Autor: Lakshmanan LN; Institute for Chemical and Bioengineering, ETH Zurich, Zurich 8093, Switzerland Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117585, Singapore., Gruber J; Yale-NUS College, Department of Biochemistry, Neurobiology and Ageing Program, National University of Singapore, Singapore 117599, Singapore., Halliwell B; Department of Biochemistry, Neurobiology and Ageing Program, Centre for Life Sciences (CeLS), National University of Singapore, Singapore 117599, Singapore., Gunawan R; Institute for Chemical and Bioengineering, ETH Zurich, Zurich 8093, Switzerland Swiss Institute of Bioinformatics, Quartier Sorge - Batiment Genopode, 1015 Lausanne, Switzerland rudi.gunawan@chem.ethz.ch.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2015 Apr 30; Vol. 43 (8), pp. 4098-108. Date of Electronic Publication: 2015 Apr 08.