Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Lakshmanan Govindasamy"'
Autor:
George V Aslanidi, Angela E Rivers, Luis Ortiz, Liujiang Song, Chen Ling, Lakshmanan Govindasamy, Kim Van Vliet, Mengqun Tan, Mavis Agbandje-McKenna, Arun Srivastava
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59142 (2013)
The ubiquitin-proteasome pathway plays a critical role in the intracellular trafficking of AAV2 vectors, and phosphorylation of certain surface-exposed amino acid residues on the capsid provides the primary signal for ubiquitination. Removal of sever
Externí odkaz:
https://doaj.org/article/ad3cc4e20a7a4d0b901038d575181fd8
Autor:
James M. Wilson, Joshua J. Sims, Martin Lock, April R. Giles, Lakshmanan Govindasamy, Mauricio R. Alvira, Turner Kevin
Publikováno v:
Molecular Therapy. 26:2848-2862
Post-translational modification of the adeno-associated virus capsids is a poorly understood factor in the development of these viral vectors into pharmaceutical products. Here we report the extensive capsid deamidation of adeno-associated virus sero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2336142e0fcdbdce966c79c29c739c9a
https://doi.org/10.1016/j.ymthe.2018.09.013
https://doi.org/10.1016/j.ymthe.2018.09.013
Publikováno v:
Journal of Virology. 92
Recent clinical trials have demonstrated the potential of adeno-associated virus (AAV)-based vectors for treating rare diseases. However, significant barriers remain for the translation of these vectors into widely available therapies. In particular,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a9e81c2f90dd6840dbf2f34cfa8e40
https://doi.org/10.1128/jvi.01011-18
https://doi.org/10.1128/jvi.01011-18
Autor:
Nicholas Muzyczka, John A. Chiorini, Mavis Agbandje-McKenna, Michael A. DiMattia, Lakshmanan Govindasamy, Sergei Zolotukhin, Robert McKenna, Brittney L. Gurda, Sujata Halder
Publikováno v:
Journal of Virology. 87:11187-11199
The adeno-associated viruses (AAVs) display differential cell binding, transduction, and antigenic characteristics specified by their capsid viral protein (VP) composition. Toward structure-function annotation, the crystal structure of AAV5, one of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899dbd7173a7da7dc6aa4afe09b98852
https://doi.org/10.1128/jvi.00867-13
https://doi.org/10.1128/jvi.00867-13
Autor:
Arun Srivastava, Sergei Zolotukhin, Giridhara R. Jayandharan, Mavis Agbandje-McKenna, Luis Ortiz, Lakshmanan Govindasamy, Chen Ling, Angela Rivers, George Aslanidi
Publikováno v:
Vaccine. 30:3908-3917
Phosphorylation of surface-exposed tyrosine residues negatively impacts the transduction efficiency of recombinant AAV2 vectors. Pre-treatment of cells with specific cellular serine/threonine kinase inhibitors also significantly increased the transdu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d458c760d72e99d679e415b149a6c11
https://doi.org/10.1016/j.vaccine.2012.03.079
https://doi.org/10.1016/j.vaccine.2012.03.079
Autor:
Qingzhao Wang, Lonnie O. Ingram, Mun Su Rhee, Phi Minh Do, Zhentao Sun, Lakshmanan Govindasamy, Keelnatham T. Shanmugam
Publikováno v:
Microbiology. 158:1350-1358
Pyruvate dehydrogenase (PDH) of Escherichia coli is inhibited by NADH. This inhibition is partially reversed by mutational alteration of the dihydrolipoamide dehydrogenase (LPD) component of the PDH complex (E354K or H322Y). Such a mutation in lpd le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2b13cca72827e833694dbb95fc5a1a
https://doi.org/10.1099/mic.0.055590-0
https://doi.org/10.1099/mic.0.055590-0
Autor:
Swati Yadav, Shen Shen, Kari Debbink, Lakshmanan Govindasamy, Mavis Agbandje-McKenna, Nagesh Pulicherla, Aravind Asokan
Publikováno v:
Molecular Therapy. 19(6):1070-1078
We report the generation of a new class of adeno-associated virus serotype 9 (AAV9)-derived vectors displaying selective loss of liver tropism and demonstrating potential for cardiac and musculoskeletal gene transfer applications. Random mutagenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e181cc2c07b1e97d09557f670d58b67
Autor:
Seok-Hong Min, Alfred S. Lewin, Li Zhong, Antonette Bennett, Hilda Petrs-Silva, William W. Hauswirth, Giridhara R. Jayandharan, Mavis Agbandje-McKenna, Jijing Pang, Andy W. Neeley, Arun Srivastava, Astra Dinculescu, Qiuhong Li, Wen-Tao Deng, Lakshmanan Govindasamy, Baozheng Li, Vince A. Chiodo
Publikováno v:
Molecular Therapy. 19(2):293-301
Vectors based on adeno-associated virus serotype 2 (AAV2) have been used extensively in many gene-delivery applications, including several successful clinical trials for one type of Leber congenital amaurosis in the retina. Many studies have focused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e362f61cf1300110c40e5ed8b83cda7
Autor:
Robert Ng, Mavis Agbandje-McKenna, R. Jude Samulski, Robert McKenna, Brittney L. Gurda, Kristin N. Parent, Timothy S. Baker, Lakshmanan Govindasamy, Olga G. Kozyreva
Publikováno v:
Journal of Virology. 84:12945-12957
The three-dimensional structure of adeno-associated virus (AAV) serotype 6 (AAV6) was determined using cryo-electron microscopy and image reconstruction and using X-ray crystallography to 9.7- and 3.0-Å resolution, respectively. The AAV6 capsid con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e323c27954350dcd8d690c7b7e958bcc
https://doi.org/10.1128/jvi.01235-10
https://doi.org/10.1128/jvi.01235-10
Autor:
Anurima Majumder, György M. Keserü, Andrew T. Magis, Tímea Polgár, Robert W. Allan, Lakshmanan Govindasamy, Peter P. Sayeski, Mavis Agbandje-McKenna, Rebekah Baskin, Kirpal S. Bisht, Gary W. Reuther, Robert Kiss
Publikováno v:
Journal of Biological Chemistry. 285:31399-31407
Somatic mutations in the Jak2 protein, such as V617F, cause aberrant Jak/STAT signaling and can lead to the development of myeloproliferative neoplasms. This discovery has led to the search for small molecule inhibitors that target Jak2. Using struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e81744b82cb001dc2fc18e786b5246b
https://doi.org/10.1074/jbc.m110.168211
https://doi.org/10.1074/jbc.m110.168211