Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lakshman Varanasi"'
Frequency of chromosome 17 polysomy in relation to CEP17 copy number in a large breast cancer cohort
Autor:
Marian Hajduch, Lakshman Varanasi, Sandra Donevska, Zdenek Kolar, Katerina Bouchalova, Vladimira Koudelakova, Jana Vrbkova, Radek Trojanec
Publikováno v:
Genes, Chromosomes and Cancer. 55:409-417
Eligibility to anti-HER2 therapy for breast tumors strictly depends on demonstrating HER2 overexpression (by immunohistochemistry) or HER2 gene amplification by in situ hybridization (ISH), usually defined by the ratio of HER2 gene to chromosome 17 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::def1fd8aef8c8a0615fdfc189c0fdd8e
https://doi.org/10.1002/gcc.22337
https://doi.org/10.1002/gcc.22337
Autor:
Marian Hajduch, Gabriela Rylova, Jan Hlaváč, Lakshman Varanasi, Miroslav Soural, Dusan Holub, Tomas Ozdian, Petr Dzubak
Publikováno v:
Current Drug Targets. 16:60-76
Target discovery using the molecular approach, as opposed to the more traditional systems approach requires the study of the cellular or biological process underlying a condition or disease. The approaches that are employed by the "bench" scientist m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26fc228c40296316b0dfe3ee779c1892
https://doi.org/10.2174/1389450115666141120110323
https://doi.org/10.2174/1389450115666141120110323
Autor:
Christina O. Lee, Toshifumi Hara, Sven Bilke, Yu-an Yang, Yuelin Zhu, Murugan Subramanian, Xing Lu, Lakshman Varanasi, Ji Luo, Paul S. Meltzer, Matthew F. Jones, Marbin Pineda, Princy Francis, Ashish Lal, Lalage M. Wakefield, Xiaoling Li, Robert L. Walker, Luis A. Martinez, Stefan Ambs, Sudha Sharma
Publikováno v:
Oncogene. 34:1094-1104
Most p53 mutations in human cancers are missense mutations resulting in a full-length mutant p53 protein. Besides losing tumor suppressor activity, some hotspot p53 mutants gain oncogenic functions. This effect is mediated in part, through gene expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d917bb1efd79e81ca9448bca102375be
https://doi.org/10.1038/onc.2014.46
https://doi.org/10.1038/onc.2014.46
Autor:
Marian Hajduch, Gabriela Rylova, Jiri Rehulka, Petr Dzubak, Hanus Slavik, Tomas Ozdian, Pawel Znojek, Zuzana Maceckova, Pavel Moudry, Lakshman Varanasi, Jana Vaclavkova, Jarmila Stanková, Dusan Holub, Juan B. De Sanctis
Publikováno v:
Journal of proteomics. 162
Oxaliplatin is widely used to treat colorectal cancer in both palliative and adjuvant settings. It is also being tested for use in treating hematological, esophageal, biliary tract, pancreatic, gastric, and hepatocellular cancers. Despite its routine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b620cd29b7cedccaa70b7f956c0ea1f
https://pubmed.ncbi.nlm.nih.gov/28478306
https://pubmed.ncbi.nlm.nih.gov/28478306
Autor:
Jonathan P. Hosler, Lakshman Varanasi
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1817(4):545-551
We review studies of subunit III-depleted cytochrome c oxidase (CcO III (−)) that elucidate the structural basis of steady-state proton uptake from solvent into an internal proton transfer pathway. The removal of subunit III from R. sphaeroides CcO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e36919f23e5abcd3e50eaf9e4d0e85
Autor:
Jonathan P. Hosler, Lakshman Varanasi
Publikováno v:
Biochemistry. 50:2820-2828
In order to characterize protein structures that control proton uptake, forms of cytochrome c oxidase (CcO) containing a carboxyl or a thiol group in line with the initial, internal waters of the D pathway for proton transfer have been assayed in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c4e0c2485d96282cfb8519c4c5de6e
https://doi.org/10.1021/bi102002v
https://doi.org/10.1021/bi102002v
Autor:
Lakshman Varanasi, Petr Džubák, Zuzana Maceckova, Jana Vaclavkova, Hanus Slavik, Gabriela Rylova, Pawel Znojek, Tomáš Oždian, Jiři Rehulka, Dusan Holub, Jarmila Stanková, Marian Hajduch, Pavel Moudry, Juan B. De Sanctis
Publikováno v:
Cancer Research. 78:455-455
Oxaliplatin is a platinum-based drug playing a critical role in the treatment of colorectal carcinoma and various Hodgkin and non-Hodgkin lymphomas. The primary mechanism of action is reported to be DNA damage and double strand breaks response. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e1485223de1e3e6996c88c4724a1da9
https://doi.org/10.1158/1538-7445.am2018-455
https://doi.org/10.1158/1538-7445.am2018-455
Publikováno v:
BioMed Research International, Vol 2016 (2016)
BioMed Research International
BioMed Research International
Quercetin and phenylpropanoids are well known chemoprotective compounds identified in many plants. This study was aimed at determining their effects on activation of Nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant response element (Nrf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2234e9c71677d0e64082d7b5f08bc65
https://doaj.org/article/c90e7e9e7600437fb995b5deed6a8e43
https://doaj.org/article/c90e7e9e7600437fb995b5deed6a8e43
Frequency of chromosome 17 polysomy in relation to CEP17 copy number in a large breast cancer cohort
Autor:
Vladimira, Koudelakova, Radek, Trojanec, Jana, Vrbkova, Sandra, Donevska, Katerina, Bouchalova, Zdenek, Kolar, Lakshman, Varanasi, Marian, Hajduch
Publikováno v:
Genes, chromosomescancer. 55(5)
Eligibility to anti-HER2 therapy for breast tumors strictly depends on demonstrating HER2 overexpression (by immunohistochemistry) or HER2 gene amplification by in situ hybridization (ISH), usually defined by the ratio of HER2 gene to chromosome 17 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2e6da925fdc498a1fa714d1c0617eb56
https://pubmed.ncbi.nlm.nih.gov/26847577
https://pubmed.ncbi.nlm.nih.gov/26847577
Autor:
Rodney C. Baker, Denise A. Mills, Jimmy Gray, Jonathan P. Hosler, Chris Purser, Lakshman Varanasi, Anna Murphree
Publikováno v:
Biochemistry. 45:14896-14907
Subunit III of the three-subunit catalytic core of cytochrome c oxidase (CcO) contains no metal centers, but it does bind two lipids, within a deep cleft, in binding sites conserved from bacteria to humans. Subunit III binds to subunit I, where it pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5b3982b6200f95297b2be248b673f3
https://doi.org/10.1021/bi061390q
https://doi.org/10.1021/bi061390q