Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lakshman Samala"'
Autor:
Bryce Alden Harrison, Lakshman Samala, Nita Patel, Zheng Y. Almstead, N. Andrew Whitlock, Ross Mabon, Dennis S. Rice, Nicole Cathleen Goodwin, Beth McKnight, Yulian Zhang, Jason P. Healy, Shuli Wang, Suma Gopinathan, Gardyan Michael Walter, David B. Rawlins, Alan Wilson, Terry R. Stouch, Ying Liu, Brian D. Hamman, Brett A. Marinelli, Hugh Alfred Burgoon
Publikováno v:
ACS Medicinal Chemistry Letters. 6:84-88
The structure of LX7101, a dual LIM-kinase and ROCK inhibitor for the treatment of ocular hypertension and associated glaucoma, is disclosed. Previously reported LIM kinase inhibitors suffered from poor aqueous stability due to solvolysis of the cent
Autor:
Haihong Jin, Zhi-Cai Shi, Alan Main, Lakshman Samala, Chengmin Zhang, Qingyun Liu, Giovanni Cianchetta, Xiang Qing Yu, Ying Wang, David R. Powell, Weimei Sun, Zhi Ming Ding, Qi M. Yang, Kunjian Gu, Yi Zang, Alan Wilson, Ashok Tunoori, S. David Kimball, Terry R. Stouch, Arokiasamy Devasagayaraj, Brett A. Marinelli, Sheldon Scott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5229-5232
Tryptophan hydroxylase (TPH) is a key enzyme in the synthesis of serotonin. As a neurotransmitter, serotonin plays important physiological roles both peripherally and centrally. Here we describe the discovery of substituted triazines as a novel class
Publikováno v:
Tetrahedron Letters. 35:3621-3624
The crucial highly functionalized CD substructure of taxol has been synthesized featuring a stereocontrolled Boord reaction and stereoselective Sharpless allylic oxidation sequence leading to oxetane formation.
Publikováno v:
Tetrahedron Letters. 35:3617-3620
Synthesis of a highly functionalized taxol skeleton core making use of Diels-Alder and a novel oxygen bridge opening strategies leading to functionalized C-ring is described.
Autor:
Zhi-Cai Shi, Arokiasamy Devasagayaraj, Kunjian Gu, Haihong Jin, Brett Marinelli, Lakshman Samala, Sheldon Scott, Terry Stouch, Ashok Tunoori, Ying Wang, Chengmin Zhang, S. David Kimball, Alan J. Main, Weimei Sun, Yi Zang, Qi Yang, Amr Nouraldeen, Xiang-Qing Yu, Eric Buxton, Shiv Patel
Publikováno v:
Journal of Medicinal Chemistry; Jun2008, Vol. 51 Issue 13, p3684-3687, 4p
Publikováno v:
Chemistry Letters; March 1996, Vol. 25 Issue: 3 p211-212, 2p