Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lakshman Puli"'
Autor:
Taisia Rolova, Lakshman Puli, Johanna Magga, Hiramani Dhungana, Katja Kanninen, Sara Wojciehowski, Antero Salminen, Heikki Tanila, Jari Koistinaho, Tarja Malm
Publikováno v:
Neurobiology of Disease, Vol 64, Iss , Pp 16-29 (2014)
Inflammation is a major mechanism of acute brain injury and chronic neurodegeneration. This neuroinflammation is known to be substantially regulated by the transcription factor NF-κB, which is predominantly found in the form of heterodimer of p65 (R
Externí odkaz:
https://doaj.org/article/f0b6c68beb8e49dd9a1dedcd9f56ddc1
Cerebrospinal fluid biomarker and brain biopsy findings in idiopathic normal pressure hydrocephalus.
Autor:
Okko T Pyykkö, Miikka Lumela, Jaana Rummukainen, Ossi Nerg, Toni T Seppälä, Sanna-Kaisa Herukka, Anne M Koivisto, Irina Alafuzoff, Lakshman Puli, Sakari Savolainen, Hilkka Soininen, Juha E Jääskeläinen, Mikko Hiltunen, Henrik Zetterberg, Ville Leinonen
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91974 (2014)
BackgroundThe significance of amyloid precursor protein (APP) and neuroinflammation in idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD) is unknown.ObjectiveTo investigate the role of soluble APP (sAPP) and amyloid beta (A
Externí odkaz:
https://doaj.org/article/2474efa1786747989d060d4f63d44cbd
Autor:
Tiina Laiterä, Timo Sarajärvi, Annakaisa Haapasalo, Lakshman Puli, Tarja Kauppinen, Petra Mäkinen, Tuomas Rauramaa, Heikki Tanila, Juha E Jääskeläinen, Irina Alafuzoff, Hilkka Soininen, Ville Leinonen, Mikko Hiltunen
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93717 (2014)
The potential similarity between the brain pathology of idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer disease (AD) is intriguing and thus further studies focusing on the underlying molecular mechanisms may offer valuable information f
Externí odkaz:
https://doaj.org/article/bad24f4c426749caa7432b273f68074c
Publikováno v:
Drug discovery today. 26(3)
The pathogenesis of Alzheimer's disease (AD) involves neurodegeneration following the deposition of β-amyloid (Aβ) plaques and neurofibrillary tangles in vulnerable brain regions. The vulnerability of the brain to reactive oxygen species (ROS) is n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d431184ffce7a5c128c4f0dbbfb5f4
https://pubmed.ncbi.nlm.nih.gov/33306995
https://pubmed.ncbi.nlm.nih.gov/33306995
Autor:
Jari Koistinaho, Antero Salminen, Johanna Magga, Katja M. Kanninen, Lakshman Puli, Hiramani Dhungana, Heikki Tanila, Tarja Malm, Sara Wojciehowski, Taisia Rolova
Publikováno v:
Neurobiology of Disease, Vol 64, Iss, Pp 16-29 (2014)
Inflammation is a major mechanism of acute brain injury and chronic neurodegeneration. This neuroinflammation is known to be substantially regulated by the transcription factor NF-κB, which is predominantly found in the form of heterodimer of p65 (R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff33fe3e2f9388f9d3a83c21d8c4ffc
https://doi.org/10.1016/j.nbd.2013.12.003
https://doi.org/10.1016/j.nbd.2013.12.003
Autor:
George M. Alley, Balmiki Ray, Jason A. Bailey, Lakshman Puli, Heikki Tanila, De Mao Chen, Debomoy K. Lahiri, Pradeep Banerjee
Publikováno v:
Journal of Neuroscience Research. 88:143-154
Memantine is a moderate-affinity, uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist that stabilizes cognitive, functional, and behavioral decline in patients with moderate to severe Alzheimer's disease (AD). In AD, the extracellular depos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89ed2dfecd9c8a5031245ef4e04f1077
https://doi.org/10.1002/jnr.22172
https://doi.org/10.1002/jnr.22172
Autor:
Ossi Nerg, Lakshman Puli, Henrik Zetterberg, Hilkka Soininen, Jouni Ihalainen, Mikael von und zu Fraunberg, Okko T. Pyykkö, Heikki Tanila, Anne M. Koivisto, Mikko Hiltunen, Ville Leinonen, Juha E. Jääskeläinen, Irina Alafuzoff, Toni T. Seppälä, Seppo Helisalmi, Jaana Rummukainen, Jaakko Rinne, Sanna-Kaisa Herukka
Publikováno v:
Journal of Alzheimer's disease : JAD. 46(1)
Background: Amyloid-beta (A beta(1-42)), total tau (T-tau), and phosphorylated tau (P-tau(181)) in the cerebrospinal fluid (CSF) are the most promising biomarkers of Alzheimer's disease (AD). Still, little is known about the dynamics of these molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa33b338171eddf5332a3954bb660661
https://pubmed.ncbi.nlm.nih.gov/25720406
https://pubmed.ncbi.nlm.nih.gov/25720406
Publikováno v:
Current Alzheimer research. 11(7)
Alzheimer’s disease (AD) is a chronic neurodegenerative disease associated with intracerebral accumulation of aggregated amyloid-beta (Aβ ) and tau proteins, as well as neuroinflammation. Human intravenous immunoglobulin (IVIG) is a mixture of pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf229fa46e37cd4aafc7e3cf1ea59ba4
https://pubmed.ncbi.nlm.nih.gov/25115546
https://pubmed.ncbi.nlm.nih.gov/25115546
Autor:
Heikki Tanila, Timo Sarajärvi, Hilkka Soininen, Tuomas Rauramaa, Irina Alafuzoff, Tarja Kauppinen, Lakshman Puli, Petra Mäkinen, Annakaisa Haapasalo, Tiina Laiterä, Juha E. Jääskeläinen, Mikko Hiltunen, Ville Leinonen
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93717 (2014)
PLoS ONE
PLoS ONE
The potential similarity between the brain pathology of idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer disease (AD) is intriguing and thus further studies focusing on the underlying molecular mechanisms may offer valuable information f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51854f028ef5851bebf8c2c40a9dd2db
http://europepmc.org/articles/PMC3974803?pdf=render
http://europepmc.org/articles/PMC3974803?pdf=render
Autor:
Lakshman Puli, Irina Alafuzoff, Mikko Hiltunen, Henrik Zetterberg, Hilkka Soininen, Sakari Savolainen, Ville Leinonen, Anne M. Koivisto, Juha E. Jääskeläinen, Toni T. Seppälä, Sanna-Kaisa Herukka, Ossi Nerg, Okko T. Pyykkö, Jaana Rummukainen, Miikka Lumela
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 3, p e91974 (2014)
PLoS ONE, Vol 9, Iss 3, p e91974 (2014)
BackgroundThe significance of amyloid precursor protein (APP) and neuroinflammation in idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's disease (AD) is unknown.ObjectiveTo investigate the role of soluble APP (sAPP) and amyloid beta (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29df13de998633ba76faa77ea7eb99ce
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-224020
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-224020
