Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Lakshman Bindu"'
Autor:
Timothy H. Tran, Albert H. Chan, Lucy C. Young, Lakshman Bindu, Chris Neale, Simon Messing, Srisathiyanarayanan Dharmaiah, Troy Taylor, John-Paul Denson, Dominic Esposito, Dwight V. Nissley, Andrew G. Stephen, Frank McCormick, Dhirendra K. Simanshu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The molecular details of the RAS-RAF interaction are still not fully understood. Here, the authors present crystal structures of wild-type and mutant KRAS in complex with the RAS-binding and membrane-interacting cysteine-rich domains of RAF1, and pro
Externí odkaz:
https://doaj.org/article/8075c5993bfb4f61bc8bb5d453321337
Autor:
Farid A. Siddiqui, Catharina Alam, Petja Rosenqvist, Mikko Ora, Ahmed Sabt, Ganesh babu Manoharan, Lakshman Bindu, Sunday Okutachi, Marie Catillon, Troy Taylor, Omaima M. Abdelhafez, Harri Lönnberg, Andrew G. Stephen, Anastassios C. Papageorgiou, Pasi Virta, Daniel Abankwa
Publikováno v:
ACS Omega, Vol 5, Iss 1, Pp 832-842 (2019)
Externí odkaz:
https://doaj.org/article/3c425549098741d9ab67574c49453cfb
Autor:
Andrew G. Stephen, Farid Ahmad Siddiqui, Lakshman Bindu, Pasi Virta, Ganesh babu Manoharan, Mikko Ora, Marie Catillon, Catharina Alam, Daniel Abankwa, Omaima M. Abdelhafez, Anastassios C. Papageorgiou, Sunday Ojochegbe Okutachi, Ahmed Sabt, Harri Lönnberg, Petja Rosenqvist, Troy Taylor
Publikováno v:
ACS Omega, Vol 5, Iss 1, Pp 832-842 (2019)
ACS Omega
ACS Omega
The trafficking chaperone PDE6D (also referred to as PDEδ) has been nominated as a surrogate target for K-Ras4B (hereafter K-Ras). Arl2-assisted unloading of K-Ras from PDE6D in the perinuclear area is significant for correct K-Ras localization and
KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner
Autor:
Marco Tonelli, Simon Messing, Frank McCormick, Lakshman Bindu, Rodolfo Ghirlando, Constance Agamasu, Dwight V. Nissley, Troy Taylor, Andrew G. Stephen, Timothy H. Tran
Publikováno v:
Biophysical journal, vol 116, iss 6
Biophysical Journal
Biophysical Journal
Deregulation of KRAS4b signaling pathway has been implicated in 30% of all cancers. Membrane localization of KRAS4b is an essential step for the initiation of the downstream signaling cascades that guide various cellular mechanisms. KRAS4b plasma mem
Autor:
Alfa Herrera, Lakshman Bindu, Vadim Gaponenko, Matthew B. Kieffer, Patrick J. Woida, Matthew Holderfield, Andrew G. Stephen, Wayne F. Anderson, George Minasov, Marco Biancucci, Avik Banerjee, Maria Teresa Abreu-Blanco, Karla J. F. Satchell
Publikováno v:
Science Signaling. 11
The Ras-ERK (extracellular signal–regulated kinase) pathway is critical for controlling cell proliferation, and its aberrant activation drives the growth of various cancers. Because many pathogens produce toxins that inhibit Ras activity, efforts t
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Timothy H. Tran, Srisathiyanarayanan Dharmaiah, Rodolfo Ghirlando, Frank McCormick, Dwight V. Nissley, Dominic Esposito, Peter Frank, Lakshman Bindu, Dhirendra K. Simanshu, Andrew G. Stephen, William K. Gillette
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 44
Farnesylation and carboxymethylation of KRAS4b (Kirsten rat sarcoma isoform 4b) are essential for its interaction with the plasma membrane where KRAS-mediated signaling events occur. Phosphodiesterase-δ (PDEδ) binds to KRAS4b and plays an important
Autor:
Andrew G. Stephen, Ming Zhou, Suzanne I. Specht, Matthew Holderfield, Deborah K. Morrison, David E. Durrant, Maria Teresa Abreu-Blanco, Lakshman Bindu, Daniel A. Ritt
Publikováno v:
Molecular cell. 64(5)
Ras pathway signaling plays a critical role in cell growth control and is often upregulated in human cancer. The Raf kinases selectively interact with GTP-bound Ras and are important effectors of Ras signaling, functioning as the initiating kinases i
Autor:
Maria Abreu Blanco, Shelley Perkins, Dwight V. Nissley, Cammi Bittner, Zhaojing Meng, Lakshman Bindu, Patrick Alexander, Dominic Esposito, Matthew Holderfield, Rodolfo Ghirlando, Matthew J. Fivash, Oleg Chertov, Peter Frank, Que Van, Jane E. Jones, Frank McCormick, Andrew G. Stephen, William K. Gillette, Carissa Grose
Publikováno v:
Scientific reports, vol 5, iss 1
Scientific Reports
Scientific Reports
Prenylated proteins play key roles in several human diseases including cancer, atherosclerosis and Alzheimer’s disease. KRAS4b, which is frequently mutated in pancreatic, colon and lung cancers, is processed by farnesylation, proteolytic cleavage a