Targeting the gp130/STAT3 Axis Attenuates Tumor Microenvironment Mediated Chemoresistance in Group 3 Medulloblastoma Cells

Autor: Lakshana Sreenivasan, Ling Vicky Li, Pascal Leclair, Chinten James Lim

Publikováno v: Cells, Vol 11, Iss 3, p 381 (2022)

Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Of the four molecular subgroups, Group 3 MB is the most aggressive and has the worst prognosis. To understand the origins of chemoresistance involving IL-6/STAT3 signaling, we u

Externí odkaz: https://doaj.org/article/7e5a57ea7fce4f5387357ff02a834f6d

Abstract LB133: Targetting IL-6/gp130 signalling axis attenuates acquired drug resistance in medulloblastoma

Autor: Pascal Leclair, Lakshana Sreenivasan, Chinten James Lim

Publikováno v: Cancer Research. 81:LB133-LB133

Medulloblastoma (MB) is the most common pediatric brain tumour comprising of four distinct molecular subgroups exhibiting high level of intertumoural heterogeneity. The standard multimodal treatment yields a survival rate of 70% but the aggressive tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e851a57fa77e4ef4c6728eb1858bdc6
https://doi.org/10.1158/1538-7445.am2021-lb133

Contributors

Autor: Juan Andres Abin-Carriquiry, Zeliha S. Akdemir, Alessio Alfieri, Bahareh Amin, Giovanni Appendino, Csilla Ari, Florencia Arredondo, Michael Aschner, William J. Banz, Doris Barcellona, Aysegul Bayir, Muchukunte Mukunda Srinivas Bharath, Fernanda Blasina, Carlo Blundo, Karin Borges, James M. Brimson, Michela Bruschini, Valentina Carito, Francisco Javier Carod Artal, Marco Castori, Mauro Ceccanti, George Chaldakov, H.M. Chandola, Neelima B. Chauhan, Joseph L. Cheatwood, Suengmok Cho, Stefania Ciafrè, Chiara Cipollina, Rich W. Clough, Dominic D’Agostino, Federico Dajas, Sukanya Das, Gurman Dhaliwal, Filippo Di Sacco, Marcela Díaz, Carolina Echeverry, Marco Fiore, Francesco Forfori, Federico Franceschi, Gislaine Francieli da Silva, Stephanie J.B. Fretham, Marilù Giacalone, Adriana del Giglio, Auro del Giglio, Francesco Giunta, Krishna Gokul, Lixia Guo, Lan Thi Hoàng Nguyễn, Hossein Hosseinzadeh, Apurva Kumar Joshi, Vijaya Juturu, Cigdem Kahraman, Salman Khan, Yeong Shik Kim, Pavel Klein, Eric H. Kossoff, Jianhui Liu, Giovanni E. Mann, Francesco Marongiu, Marcela Martínez, Ebany J. Martinez-Finley, Pamela A. McCombe, Tanya S. McDonald, Jogender Mehla, Nara Lins Meira Quintão, Ricka D. Messer, null Muralidhara, Rajeswara Babu Mythri, Marjan Nassiri-Asl, Tirang R. Neyestani, Shyuan T. Ngo, Sara De Nicolò, Nicola Pagnucci, Kiran S. Panickar, Raffaele Pilla, Elizabeth Pogge, null Khanh vinh quốc Lương, Felicia Rivera, Lilian Wunsch Rocha, Sanya Roysommuti, Alexander G. Schauss, Adrienne C. Scheck, Francisco J. Schopfer, Derek A. Schreihofer, Hari Sharma, Makoto Shimizu, Scott D. Smid, Lakshana Sreenivasan, Frederik J. Steyn, Motoki Tagami, Hideaki Takahata, Kah Ni Tan, Luigi Tarani, I. Irem Tatli, Tewin Tencomnao, Paola Tirassa, Stefano Togni, Alev Tosun, Ippolito Traupe, Ivana Tyrlikova, Lucía Vaamonde, Ronald Ross Watson, Eric C. Woolf, James Michael Wyss, Kazuo Yamagata, Fei Yin, Cristina Zuliani, Junzeng Zhang, Jeffrey Zidichouski

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a19f17016ec6bd26208e6155092c8cb
https://doi.org/10.1016/b978-0-12-411462-3.01002-x

List of Contributors

Autor: José-Alfonso Abecia, Ashok Agarwal, Diana Anderson, Susana Astiz, Adolf Baumgartner, Ranveer Singh Bedwal, Zulfiqar A. Bhutta, Edson Borges, Edolene Bosman, Jean D. Brender, Cynthia H. Chuang, Frank H. Comhaire, Giovanni Corona, Giulia Dante, Wim A.E. Decleer, Michael C. Dennedy, Sejal Doshi, Damayanthi Durairajanayagam, Aoife M. Egan, Omer Erdeve, Aletta Dorothea Esterhuizen, Sandro C. Esteves, Enrico Facchiano, Fabio Facchinetti, Daniela Paes de Almeida Ferreira Braga, J. Gual Frau, Tod Fullston, C. Abad Gairín, Kathryn Gebhardt, Antonio Gonzalez-Bulnes, Jaime Gosalvez, N. Hannaoui Hadi, Batool A. Haider, Roger Hart, Annemieke Hoek, Muhammad Sameem Javed, Ammar Ahmad Khan, Dariusz Kokoszyński, Jennifer L. Kraschnewski, Walter K. Kuchenbecker, Deepa Kumari, Lesia O. Kurlak, Abbie Laing, Fiona Langdon, J.L.M.R. Leroy, Marcello Lucchese, Michaela Luconi, Mario Maggi, Ana Meikle, Hiten D. Mistry, Ricardo Miyaoka, Lisa J. Moran, Aditi Mulgund, Neena Nair, Isabella Neri, Mehmet Yekta Oncel, A. García Peiró, Karen P. Phillips, Alan Scott Polackwich, Sayali Chintamani Ranade, Muhammad Atif Randhawa, Leonardo Reis, Francisco Antonio Rodrigues, Mandy J. Rodrigues, Edmund S. Sabanegh, Muhammad Wasim Sajid, Giulia Scaravelli, Thomas Ernst Schmid, Cecilia Sosa, Roberta Spoletini, Lakshana Sreenivasan, Helena J. Teede, Gülcan Türker, Eva Tvrda, S.D.M. Valckx, Carolina Viñoles, Anna Wilkanowska, Linda Wu, Deirdre Zander-Fox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d1f0eeea03a9e728759af3804277695
https://doi.org/10.1016/b978-0-12-800872-0.00040-8