Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lakmini Widanapathirana"'
Autor:
Jeffrey M. Ting, Swapnil Tale, Anatolii A. Purchel, Seamus D. Jones, Lakmini Widanapathirana, Zachary P. Tolstyka, Li Guo, Steven J. Guillaudeu, Frank S. Bates, Theresa M. Reineke
Publikováno v:
ACS Central Science, Vol 2, Iss 10, Pp 748-755 (2016)
Externí odkaz:
https://doaj.org/article/a7bcfd77168c4bb1b3a0616205793f50
Autor:
David Watrous, Jonathan T. Su, Mark A. Marzinke, Dipu Karunakaran, Georgina L Dobek, M. Melissa Peet, Ewa Bryndza Tfaily, Elizabeth Pearson, Jiang Qiu, Lakmini Widanapathirana, Ronald S. Veazey, Brooke Grasperge, Samuel Sung, Thomas J. Hope, Patrick F. Kiser, Solange M. Simpson, Charlette M. Cain
Publikováno v:
Antimicrobial Agents and Chemotherapy
We describe the in vitro and in vivo evaluation of a subcutaneous reservoir implant delivering tenofovir alafenamide hemifumarate (TAF) for the prevention of HIV infection. These long-acting reservoir implants were able to deliver antiretroviral drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d658c055dbaf0910c8864e01c2b040
https://pubmed.ncbi.nlm.nih.gov/31871073
https://pubmed.ncbi.nlm.nih.gov/31871073
Autor:
David Watrous, Solange M. Simpson, Lakmini Widanapathirana, Elizabeth Pearson, Jiang Qiu, Alex Evanoff, Jonathan T. Su, Patrick F. Kiser, Jorge E. Chacon, Dipu Karunakaran, Samuel Sung
Publikováno v:
Pharmaceutical Research
Purpose Sexual transmission of HIV has been clinically proven to be preventable with a once-daily oral tablet; however, missed doses dramatically increase the risk of HIV infection. Long-acting subcutaneous implants do not allow the user to miss a do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71904ec9ae0b0c1cdb4205475c901ae2
https://pubmed.ncbi.nlm.nih.gov/32296951
https://pubmed.ncbi.nlm.nih.gov/32296951
Publikováno v:
Molecular Pharmaceutics. 12:2537-2543
Excipients of natural or synthetic origin play an important role in pharmaceutical performance to enhance the solubility, bioavailability, release, and stability of insoluble drugs. Herein, a series of seven excipient models was prepared by both homo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990bc422a3e665318dd091d7edfeb9f6
https://doi.org/10.1021/acs.molpharmaceut.5b00202
https://doi.org/10.1021/acs.molpharmaceut.5b00202
Publikováno v:
Langmuir. 28:17071-17078
Macrocycles made of cholate building blocks were previously found to transport glucose readily across lipid bilayers. In this study, an (15)N, (13)Cα-labeled glycine was inserted into a cyclic cholate trimer and attached at the end of a linear trime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f030afe8121df7a032d7bfd260edbc
https://doi.org/10.1021/la303661p
https://doi.org/10.1021/la303661p
Publikováno v:
Organicbiomolecular chemistry. 10(26)
Three macrocyclic oligocholates containing a carboxyl group, a guanidinium ion, and a Cbz-protected amine, respectively, were studied as membrane transporters for hydrophilic molecules. To permeate glucose across lipid bilayers, the macrocycles stack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35de931fb7cf7c6d8dd07847d9473ccf
https://pubmed.ncbi.nlm.nih.gov/22627275
https://pubmed.ncbi.nlm.nih.gov/22627275
Autor:
Lakmini Widanapathirana, Yan Zhao
Publikováno v:
The Journal of organic chemistry. 77(10)
The aggregation of macrocyclic oligocholates with introverted hydrophilic groups and aromatic side chains was studied by fluorescence spectroscopy and liposome leakage assays. Comparison between the solution and the membrane phase afforded insight in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f898f127ad1181e5a07a8d6fc9836764
https://pubmed.ncbi.nlm.nih.gov/22524459
https://pubmed.ncbi.nlm.nih.gov/22524459
Publikováno v:
Journal of the American Chemical Society. 133(1)
Hydrophobic interactions normally are not considered a major driving force for self-assembling in a hydrophobic environment. When macrocyclic oligocholates were placed within lipid membranes, however, the macrocycles pulled water molecules from the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67fff138efd49a559128a7ac1a2ece3a
https://pubmed.ncbi.nlm.nih.gov/21142045
https://pubmed.ncbi.nlm.nih.gov/21142045