Long Noncoding RNA FENDRR Inhibits Lung Fibroblast Proliferation via a Reduction of β-Catenin

Autor: Dao Xu, Gayan Bamunuarachchi, Lakmini Kumari Senavirathna, Maria Cristina Munteanu, Quanjin Dang, David W. Kamp, Sankha Hewawasam, Paul Cheresh, Chaoqun Huang, Xiaoyun Yang, Yurong Liang, Kishore Vaddadi, Pulavendran Sivasami, Lin Liu

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 16
International Journal of Molecular Sciences, Vol 22, Iss 8536, p 8536 (2021)

Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive, and usually lethal lung disease and it has been widely accepted that fibroblast proliferation is one of the key characteristics of IPF. Long noncoding RNAs (lncRNAs) play vital roles in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed7e829f6da1c3e928337fe902ac91e6

The molecular complex of ciliary and golgin protein is crucial for skull development

Autor: Lakmini Kumari Senavirathna, Hiroyuki Yamaguchi, Matthew D. Meyer, Sheng Pan, Li He, Yoshihiro Komatsu

Publikováno v: Development

Intramembranous ossification, which consists of direct conversion of mesenchymal cells to osteoblasts, is a characteristic process in skull development. One critical role of these osteoblasts is to secrete collagen-containing bone matrix. However, it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c225494e9b06578acf24d1369c04781
https://pubmed.ncbi.nlm.nih.gov/34128978

Measuring ultra-low levels of nucleotide biomarkers using quartz crystal microbalance and SPR microarray imaging methods: A comparative analysis

Autor: Gayan Premaratne, Sadagopan Krishnan, Lakmini Kumari Senavirathna, Zainab H. Al Mubarak, Lin Liu

Publikováno v: Sensors and Actuators B: Chemical. 253:368-375

Circulating serum nucleotide biomarkers are useful indicators for early diagnosis of cancer, respiratory illnesses, and other deadly diseases. In this work, we compared detection performances of a quartz crystal microbalance (QCM), which is a mass se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8b7b5fa7c7e130343a6637470b5dd2
https://doi.org/10.1016/j.snb.2017.06.138

Hyperthermia Sensitization and Proton Beam Triggered Liposomal Drug Release for Targeted Tumor Therapy

Autor: Ruchika Fernando, Ashish Ranjan, Lakmini Kumari Senavirathna, E. R. Benton, Jerimy C. Polf, Y. Zheng, Daqing Piao, Danny Maples, Kenneth E. Bartels

Publikováno v: Pharmaceutical Research. 31:3120-3126

The objectives of this study were to: 1) determine if mild hyperthermia (40–42°C) can sensitize tumor cells for more effective proton beam radiotherapy (PBRT); 2) characterize the survival fraction of cells exposed to PBRT; and 3) characterize rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fe413be004b251d09239265372c5ae
https://doi.org/10.1007/s11095-014-1404-5

Tumor Spheroids as an In Vitro Model for Determining the Therapeutic Response to Proton Beam Radiotherapy and Thermally Sensitive Nanocarriers

Autor: Ashish Ranjan, Ruchika Fernando, Lakmini Kumari Senavirathna, Danny Maples, Jerimy C. Polf, Y Zheng

Publikováno v: Theranostics

Multicellular Tumor Spheroids (MCTS) strongly resemble tumor tissues, which makes them useful tools for radiation biology studies and screening of various chemotherapeutics. The goal of this pilot study was to use MCTS as an in vitro model to determi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55976f79af18458ea9962790dd36a732
https://doi.org/10.7150/thno.6381