Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Lakmali Munasinghage Silva"'
Autor:
Thomas Kryza, Nathalie Bock, Scott Lovell, Anja Rockstroh, Melanie L. Lehman, Adam Lesner, Janaththani Panchadsaram, Lakmali Munasinghage Silva, Srilakshmi Srinivasan, Cameron E. Snell, Elizabeth D. Williams, Ladan Fazli, Martin Gleave, Jyotsna Batra, Colleen Nelson, Edward W. Tate, Jonathan Harris, John D. Hooper, Judith A. Clements
Publikováno v:
Molecular Oncology, Vol 14, Iss 1, Pp 105-128 (2020)
Kallikrein‐related peptidase 14 (KLK14) is one of the several secreted KLK serine proteases involved in prostate cancer (PCa) pathogenesis. While relatively understudied, recent reports have identified KLK14 as overexpressed during PCa development.
Externí odkaz:
https://doaj.org/article/d544b520f038431180fefe9421c7d971
Autor:
Lakmali Munasinghage Silva, Thomas Stoll, Thomas Kryza, Carson Ryan Stephens, Marcus Lachlan Hastie, Helen Frances Irving-Rodgers, Ying Dong, Jeffrey John Gorman, Judith Ann Clements
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The cleavage preferences of Kallikrein-related peptidase 7 (KLK7) have previously been delineated using synthetic peptide libraries of fixed length, or single protein chains and have suggested that KLK7 exerts a chymotryptic-like cleavage pr
Externí odkaz:
https://doaj.org/article/0ce0071cd33d4881b0d18b43301cfac5
Autor:
Martin E. Gleave, Colleen C. Nelson, Scott Lovell, Srilakshmi Srinivasan, Anja Rockstroh, Adam Lesner, Janaththani Panchadsaram, Jonathan M. Harris, Cameron Snell, Nathalie Bock, Edward W. Tate, Ladan Fazli, Judith A. Clements, Elizabeth D. Williams, Melanie Lehman, Lakmali Munasinghage Silva, John D. Hooper, Thomas Kryza, Jyotsna Batra
Publikováno v:
Molecular Oncology, Vol 14, Iss 1, Pp 105-128 (2020)
Molecular Oncology
Molecular Oncology
Kallikrein‐related peptidase 14 (KLK14) is one of the several secreted KLK serine proteases involved in prostate cancer (PCa) pathogenesis. While relatively understudied, recent reports have identified KLK14 as overexpressed during PCa development.
Publikováno v:
Current Protocols
NeutrophilExtracellular Trap (NET) formation (NETosis) is a unique process that occurs in response to numerous stimuli. To investigate NETosis, we created a method that can be used easily without the need for complex programming abilities and commerc
Autor:
Molly W. Shaw, Niki M. Moutsopoulos, Andrew Gary Lum, Eric S. Mullins, Collin Tran, Zhen Gao, Matthew J. Flick, Lakmali Munasinghage Silva, Thomas H. Bugge
Publikováno v:
Blood
Efficient migration of macrophages to sites of inflammation requires cell surface–bound plasmin(ogen). Here, we investigated the mechanisms underlying the deficits of plasmin(ogen)-mediated macrophage migration in 2 models: murine thioglycollate-in
Autor:
Priyam Jani, Teresa Greenwell-Wild, Andrew Gary Lum, Collin Tran, Daniel Martin, Nicolas Dutzan, Kimon Divaris, Andrew D. Doyle, Vardit Kram, Thomas H. Bugge, Cary S. Agler, Francis J. Castellino, Megan M. Sibree, Matthew J. Flick, Lakmali Munasinghage Silva, Niki M. Moutsopoulos
Tissue-specific cues are critical for homeostasis at mucosal barriers. Here, we document that the clotting factor fibrin is a critical regulator of neutrophil function at mucosal barriers. We demonstrate that fibrin engages neutrophils through the α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6af2631d7460a51f7003107e35f84b49
https://doi.org/10.1101/2021.01.15.426743
https://doi.org/10.1101/2021.01.15.426743
Periodontitis is a common human inflammatory disease. In this condition, microbiota trigger excessive inflammation in oral mucosal tissues surrounding the dentition, resulting in destruction of tooth-supporting structures (connective tissue and bone)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9f4a752730cff55929791c22020155
https://europepmc.org/articles/PMC7015146/
https://europepmc.org/articles/PMC7015146/
Autor:
Thomas Stoll, Lakmali Munasinghage Silva, Christine Hoogland, Marcus L. Hastie, Judith A. Clements, Viktor Magdolen, Oded Kleifeld, Thomas Kryza, Jeffrey J. Gorman, Ying Dong, Carson R. Stephens
Publikováno v:
Mol Cell Proteomics
Kallikrein-related peptidase 7 (KLK7) is a serine peptidase that is over expressed in ovarian cancer. In vitro functional analyses have suggested KLK7 to play a cancer progressive role, although monitoring of KLK7 expression has suggested a contradic
Publikováno v:
Expert review of proteomics. 14(12)
Kallikrein-related peptidases (KLKs) are a family of serine peptidases that are deregulated in numerous pathological conditions, with a multitude of KLK-mediated functional roles implicated in the progression of cancer. Advances in multidimensional m
Autor:
Marcus L. Hastie, Thomas Kryza, Jeffrey J. Gorman, Thomas Stoll, Carson R. Stephens, Judith A. Clements, Helen F. Irving-Rodgers, Lakmali Munasinghage Silva, Ying Dong
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
The cleavage preferences of Kallikrein-related peptidase 7 (KLK7) have previously been delineated using synthetic peptide libraries of fixed length, or single protein chains and have suggested that KLK7 exerts a chymotryptic-like cleavage preference.