Výsledky vyhledávání - "Lakmal W. Boteju"

Identification and Characterization of Two G Protein-coupled Receptors for Neuropeptide FF

Publikováno v: Journal of Biological Chemistry. 275:39324-39331

The central nervous system octapeptide, neuropeptide FF (NPFF), is believed to play a role in pain modulation and opiate tolerance. Two G protein-coupled receptors, NPFF1 and NPFF2, were isolated from human and rat central nervous system tissues. NPF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5a488ab332b9fe290d764d964bd5d1
https://doi.org/10.1074/jbc.m004385200

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Identification and Characterization of Two Neuromedin U Receptors Differentially Expressed in Peripheral Tissues and the Central Nervous System

Autor: Theresa Branchek, Lakmal W. Boteju, Raisa Nagorny, Rita Raddatz, Maricel S. Guevarra, Beth Borowsky, Christophe P. G. Gerald, Gabriel S. Lerman, Evguenia V. Kouranova, Amy E. Wilson, Pierre J.-J. Vaysse, Siqun Zhou, Carlos Forray, Nika Adham, Meng Dai, Roman Artymyshyn, James A. Bonini

Publikováno v: Journal of Biological Chemistry. 275:32452-32459

Two structurally related, G-protein-coupled receptors were identified as receptors for the neuropeptide, neuromedin U. This peptide is found in highest levels in the gut and genitourinary system where it potently contracts smooth muscle but is also e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6e285f2285774657abe34f6411afc6
https://doi.org/10.1074/jbc.m004613200

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Topographical modification of melanotropin peptide analogs with .beta.-methyltryptophan isomers at position 9 leads to differential potencies and prolonged biological activities

Autor: Victor J. Hruby, Lakmal W. Boteju, Carrie Haskell-Luevano, Ira Gantz, Hiroto Miwa, Chris J. Dickinson, Tadataka Yamada, Mac E. Hadley

Publikováno v: Journal of Medicinal Chemistry. 38:4720-4729

We have introduced topographical constraints at the 9 position of a superpotent cyclic α-melanotropin analogue, Ac-Nle 4 -Asp 5 -His 6 -DPhe 7 -Arg 8 -Trp 9 -Lys 10 -NH 2, by incorporating a methyl group at the β-carbon of Trp 9 . These studies wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677c62b514470288ae018ff32ec97aab
https://doi.org/10.1021/jm00023a012

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Stereoselective total synthesis of topographically constrained designer amino acids: 2′, 6′-dimethyl-β-methyltyrosines

Autor: Xinhua Qian, Victor J. Hruby, K. C. Russell, Lakmal W. Boteju

Publikováno v: Tetrahedron. 51:1033-1054

The constrained aromatic α-amino acid 2′, 6′-dimethyl-β-methyl tyrosine (Figure 1) was designed to provide specific local constraints to peptides or peptide mimetics. We report here methods for the total asymmetric synthesis of all four stereoi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5351d07a7f3309ba0dd6dcd010d72824
https://doi.org/10.1016/0040-4020(94)00996-8

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Arylamine-Nucleoside Adduct Formation: Evidence for Arylnitrene Involvement in the Reactions of an N-Acetoxyarylamine

Autor: Lakmal W. Boteju, Patrick E. Hanna

Publikováno v: Chemical Research in Toxicology. 7:684-689

N-Acetoxyarylamines are reactive metabolites that are produced from N-arylhydroxamic acids by N-arylhydroxamic acid N,O-acyltransferase and by the acetyl coenzyme A-dependent O-acetylation of N-arylhydroxylamines. Solvolytic decomposition of 7-acetyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef405df2dee6857ff199cd2ee336d34
https://doi.org/10.1021/tx00041a014

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Asymmetric synthesis of unusual amino acids: Synthesis of optically pure isomers of N-indole- (2-mesitylenesulfonyl)-β-methyltryptophan

Autor: Lakmal W. Boteju, Xinhua Qian, Victor J. Hruby, Kirsten Wegner

Publikováno v: Tetrahedron. 50:2391-2404

We have developed methods for the synthesis of the four optically pure isomers of β-methyltryptophan with the 2-mesitylenesulfonyl indole protecting group for peptide synthesis. Starting from 3-indoleacrylic acid, the β-methyl function was generate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3d844ad84c74ce65ce90b5bcca96021
https://doi.org/10.1016/s0040-4020(01)86957-x

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Formation and anti-tumor activity of uncommon in vitro and in vivo metabolites of CPI-613, a novel anti-tumor compound that selectively alters tumor energy metabolism

Autor: Lakmal W. Boteju, Robert J. Rodriguez, King Chung Lee, Robert Shorr, Adrian Sheldon, Claudia Maturo

Publikováno v: Drug metabolism letters. 5(3)

CPI-613 is a novel anti-tumor compound with a mechanism-of-action which appears distinct from the current classes of anti-cancer agents used in the clinic. CPI-613 demonstrates both in vitro and in vivo anti-tumor activity. In vitro metabolic studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078952a6f0030f47eac775d9900778cb
https://pubmed.ncbi.nlm.nih.gov/21722089

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Tryptophan-containing 1,5-tetrazole dipeptide analogs: Synthesis of Trpψ[CN4]Nle as a cis amide bond surrogate

Autor: Victor J. Hruby, Lakmal W. Boteju

Publikováno v: Tetrahedron Letters. 34:1757-1760

The 1,5-disubstituted tetrazole dipeptide analog Z-Trp(NinZ)ψ[CN4]Nle-OBzl was synthesized in good yield and high optical purity using a modified procedure of Zabrocki et al. This dipeptide analog can be selectively deprotected at either the N or th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7e5c701bfe84e2aa3281e42e6583520
https://doi.org/10.1016/s0040-4039(00)60771-2

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