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Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes.

Autor: Lakhter AJ; Department of Pediatrics, Section of Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, Indianapolis, IN, USA.; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, 635 Barnhill Dr., Rm 2031, Indianapolis, IN, 46202, USA.; Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA., Pratt RE; Department of Pediatrics, Section of Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, Indianapolis, IN, USA.; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, 635 Barnhill Dr., Rm 2031, Indianapolis, IN, 46202, USA.; Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA., Moore RE; Department of Pediatrics, Section of Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, Indianapolis, IN, USA.; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, 635 Barnhill Dr., Rm 2031, Indianapolis, IN, 46202, USA.; Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA., Doucette KK; Department of Pediatrics, Section of Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, Indianapolis, IN, USA.; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, 635 Barnhill Dr., Rm 2031, Indianapolis, IN, 46202, USA.; Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA., Maier BF; Department of Pediatrics, Section of Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, Indianapolis, IN, USA.; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, 635 Barnhill Dr., Rm 2031, Indianapolis, IN, 46202, USA., DiMeglio LA; Department of Pediatrics, Section of Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, Indianapolis, IN, USA.; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, 635 Barnhill Dr., Rm 2031, Indianapolis, IN, 46202, USA.; Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA., Sims EK; Department of Pediatrics, Section of Pediatric Endocrinology and Diabetology, Indiana University School of Medicine, Indianapolis, IN, USA. eksims@iu.edu.; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, 635 Barnhill Dr., Rm 2031, Indianapolis, IN, 46202, USA. eksims@iu.edu.; Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA. eksims@iu.edu.

Publikováno v: Diabetologia [Diabetologia] 2018 May; Vol. 61 (5), pp. 1124-1134. Date of Electronic Publication: 2018 Feb 14.

Cyclic AMP-Epac signaling pathway contributes to repression of PUMA transcription in melanoma cells.

Autor: Lakhter AJ; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Naidu SR

Publikováno v: Melanoma research [Melanoma Res] 2017 Oct; Vol. 27 (5), pp. 411-416.

Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth.

Autor: Lakhter AJ; From the Department of Immunology and Microbiology, Indiana University School of Medicine, Indianapolis, Indiana 46202., Hamilton J; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202, and., Konger RL; Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202., Brustovetsky N; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202, and., Broxmeyer HE; From the Department of Immunology and Microbiology, Indiana University School of Medicine, Indianapolis, Indiana 46202., Naidu SR; From the Department of Immunology and Microbiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, naidus@iu.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2016 Oct 14; Vol. 291 (42), pp. 21869-21879. Date of Electronic Publication: 2016 Aug 18.

Minireview: Emerging Roles for Extracellular Vesicles in Diabetes and Related Metabolic Disorders.

Autor: Lakhter AJ; Department of Pediatrics (A.J.L., E.K.S.), Center for Diabetes and Metabolic Diseases, and Section of Pediatric Endocrinology and Diabetology (E.K.S.), Indiana University, Indianapolis, Indiana 46202., Sims EK; Department of Pediatrics (A.J.L., E.K.S.), Center for Diabetes and Metabolic Diseases, and Section of Pediatric Endocrinology and Diabetology (E.K.S.), Indiana University, Indianapolis, Indiana 46202.

Publikováno v: Molecular endocrinology (Baltimore, Md.) [Mol Endocrinol] 2015 Nov; Vol. 29 (11), pp. 1535-48. Date of Electronic Publication: 2015 Sep 22.