Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Lake Ee Khaw"'
Publikováno v:
Journal of Bacteriology. 180:809-814
The gene rapL lies within the region of the Streptomyces hygroscopicus chromosome which contains the biosynthetic gene cluster for the immunosuppressant rapamycin. Introduction of a frameshift mutation into rapL by ΦC31 phage-mediated gene replaceme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe687a6698e5bd94a373d9db6bd2388
https://doi.org/10.1128/jb.180.4.809-814.1998
https://doi.org/10.1128/jb.180.4.809-814.1998
Autor:
Ariane König, James Staunton, Jesús F. Aparicio, Lake Ee Khaw, Stephen F. Haydock, Peter F. Leadlay, Torsten Schwecke, István Molnár
Publikováno v:
Aparicio, J F, Molnár, I, Schwecke, T, König, A, Haydock, S F, Khaw, L E, Staunton, J & Leadlay, P F 1996, ' Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus : Analysis of the enzymatic domains in the modular polyketide synthase ', Gene, vol. 169, no. 1, pp. 9-16 . https://doi.org/10.1016/0378-1119(95)00800-4
The three giant multifunctional polypeptides of the rapamycin (Rp)-producing polyketide synthase (RAPS1, RAPS2 and RAPS3) have recently been shown to contain 14 separate sets, or modules, of enzyme activities, each module catalysing a specific round
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cf7d603ad01719c228d7204b108f5a
https://doi.org/10.1016/0378-1119(95)00800-4
https://doi.org/10.1016/0378-1119(95)00800-4
Autor:
Ariane König, James Staunton, Jesús F. Aparicio, Lake Ee Khaw, Stephen F. Haydock, Torsten Schwecke, Peter F. Leadlay, István Molnár
Publikováno v:
Molnár, I, Aparicio, J F, Haydock, S F, Khaw, L E, Schwecke, T, König, A, Staunton, J & Leadlay, P F 1996, ' Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus : Analysis of genes flanking the polyketide synthase ', Gene, vol. 169, no. 1, pp. 1-7 . https://doi.org/10.1016/0378-1119(95)00799-7
Analysis of the gene cluster from Streptomyces hygroscopicus that governs the biosypthesis of the polyketide immunosuppressant rapamycin (Rp) has revealed that it contains three exceptionally large open reading frames (ORFs) encoding the modular poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39150385b39b9944704fe4fe4159ce7a
https://cris.vtt.fi/en/publications/8c228b13-d2a0-4569-a0df-15088d5e0256
https://cris.vtt.fi/en/publications/8c228b13-d2a0-4569-a0df-15088d5e0256
Autor:
Jesús F. Aparicio, Torsten Schwecke, Andrew F. A. Marsden, Ian S. Galloway, István Molnár, Stephen F. Haydock, James Staunton, Ariane König, Peter F. Leadlay, Lake Ee Khaw
Publikováno v:
Haydock, S F, Aparicio, J F, Molnár, I, Schwecke, T, Khaw, L E, König, A, Marsden, A F A, Galloway, I S, Staunton, J & Leadlay, P F 1995, ' Divergent sequence motifs correlated with the substrate specificity of (methyl)malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases ', FEBS Letters, vol. 374, no. 2, pp. 246-248 . https://doi.org/10.1016/0014-5793(95)01119-Y
The amino acid sequences of a large number of polyketide synthase domains that catalyse the transacylation of either methylmalonyl-CoA or malonyl-CoA onto acyl carrier protein (ACP) have been compared. Regions were identified in which the acyltransfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc2159ec1f824b0e51131cbe4ba89ae