Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Lajos Mátés"'
Autor:
Gergely Imre, Bertalan Takács, Erik Czipa, Andrea Bakné Drubi, Gábor Jaksa, Dóra Latinovics, Andrea Nagy, Réka Karkas, Liza Hudoba, Bálint Márk Vásárhelyi, Gabriella Pankotai-Bodó, András Blastyák, Zoltán Hegedűs, Péter Germán, Balázs Bálint, Khaldoon Sadiq Ahmed Abdullah, Anna Georgina Kopasz, Anita Kovács, László G. Nagy, Farkas Sükösd, Lajos Pintér, Thomas Rülicke, Endre Barta, István Nagy, Lajos Haracska, Lajos Mátés
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 145-159 (2023)
DNA transposon-based gene delivery vectors represent a promising new branch of randomly integrating vector development for gene therapy. For the side-by-side evaluation of the piggyBac and Sleeping Beauty systems—the only DNA transposons currently
Externí odkaz:
https://doaj.org/article/11d546c2a6444753ab7f307b4cde6bdd
Autor:
Anna Georgina Kopasz, Dávid Zsolt Pusztai, Réka Karkas, Liza Hudoba, Khaldoon Sadiq Ahmed Abdullah, Gergely Imre, Gabriella Pankotai-Bodó, Ede Migh, Andrea Nagy, András Kriston, Péter Germán, Andrea Bakné Drubi, Anna Molnár, Ildikó Fekete, Virág Éva Dani, Imre Ocsovszki, László Géza Puskás, Péter Horváth, Farkas Sükösd, Lajos Mátés
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background Understanding the contribution of gene function in distinct organ systems to the pathogenesis of human diseases in biomedical research requires modifying gene expression through the generation of gain- and loss-of-function phenoty
Externí odkaz:
https://doaj.org/article/35efc12f86b64a41872e0eaea3368b04
Autor:
Franka Voigt, Lisa Wiedemann, Cecilia Zuliani, Irma Querques, Attila Sebe, Lajos Mátés, Zsuzsanna Izsvák, Zoltán Ivics, Orsolya Barabas
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Sleeping Beauty is used as a genome engineering tool in a range of organisms. Here, the authors solve an atomic structure of Sleeping Beauty (SB) transposase and model the target DNA into the active site, elucidating details that may enable the ratio
Externí odkaz:
https://doaj.org/article/e1827e65d71848d68d9652376597ea67
Autor:
Gergő Porkoláb, Mária Mészáros, András Tóth, Anikó Szecskó, András Harazin, Zsolt Szegletes, Györgyi Ferenc, András Blastyák, Lajos Mátés, Gábor Rákhely, Mária A. Deli, Szilvia Veszelka
Publikováno v:
Pharmaceutics, Vol 12, Iss 7, p 635 (2020)
Inefficient drug delivery across the blood–brain barrier (BBB) and into target cells in the brain hinders the treatment of neurological diseases. One strategy to increase the brain penetration of drugs is to use vesicular nanoparticles functionaliz
Externí odkaz:
https://doaj.org/article/7adef26adb294c8fa10a2f28fe720b4e
Autor:
Burcin Gungor, Imre Gombos, Tim Crul, Ferhan Ayaydin, László Szabó, Zsolt Török, Lajos Mátés, László Vígh, Ibolya Horváth
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89136 (2014)
Eukaryotic cells exhibit a characteristic response to hyperthermic treatment, involving morphological and cytoskeletal alterations and the induction of heat shock protein synthesis. Small GTPases of the Ras superfamily are known to serve as molecular
Externí odkaz:
https://doaj.org/article/4c0a9a1918c1435a89bb485acaeef9d8
Autor:
Wiebke Garrels, Lajos Mátés, Stephanie Holler, Anna Dalda, Ulrike Taylor, Björn Petersen, Heiner Niemann, Zsuzsanna Izsvák, Zoltán Ivics, Wilfried A Kues
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23573 (2011)
Genetic engineering can expand the utility of pigs for modeling human diseases, and for developing advanced therapeutic approaches. However, the inefficient production of transgenic pigs represents a technological bottleneck. Here, we assessed the hy
Externí odkaz:
https://doaj.org/article/1120e48e7ded4acca0a4dd3bbfb2eeb1
Autor:
Michal Pravenec, Thomas Rülicke, Zoltán Ivics, Lajos Mátés, Orsolya Ivett Hoffmann, Tien Yin Yau, Zsuzsanna Bosze, Zsuzsanna Izsvák, Vladimír Landa, Aron M. Geurts, Vaclav Zidek, László Hiripi, Sanum Bashir
Publikováno v:
Nature Protocols. 9:794-809
The laboratory rabbit (Oryctolagus cuniculus) is widely used as a model for a variety of inherited and acquired human diseases. In addition, the rabbit is the smallest livestock animal that is used to transgenically produce pharmaceutical proteins in
Autor:
Zoltán Ivics, Lajos Mátés, Tien Yin Yau, Vladimír Landa, Vaclav Zidek, Sanum Bashir, Orsolya I Hoffmann, László Hiripi, Wiebke Garrels, Wilfried A Kues, Zsuzsanna Bösze, Aron Geurts, Michal Pravenec, Thomas Rülicke, Zsuzsanna Izsvák
Publikováno v:
Nature Protocols. 9:773-793
We describe a protocol for high-efficiency germline transgenesis and sustained transgene expression in two important biomedical models, the mouse and the rat, by using the Sleeping Beauty transposon system. The procedure is based on co-injection of s
Autor:
Molly Corbett, Katja Becker, Michal Pravenec, Thomas Rülicke, Artur Rangel Filho, Matthew R. Hodges, Elena Popova, Vladimír Landa, Vaclav Zidek, Howard J. Jacob, Katharina Katter, Jozef Lazar, Carol Moreno, Orsolya Ivett Hoffmann, Anantharam Devaraj, Zoltán Ivics, Zsuzsanna Bosze, Ingrid Walter, Zsuzsanna Izsvák, Boris Jerchow, Aron M. Geurts, László Hiripi, Michael Grzybowksi, Michael Bader, Sanum Bashir, Lajos Mátés
Publikováno v:
The FASEB Journal; Vol 27
Germline transgenesis is an important procedure for functional investigation of biological pathways, as well as for animal biotechnology. We have established a simple, nonviral protocol in three important biomedical model organisms frequently used in
Autor:
Zoltán Ivics, András Szilágyi, Orsolya Barabas, Stephen R. Yant, Joseph A. Marsh, Zsuzsanna Izsvák, Lajos Mátés, György Abrusán
Publikováno v:
Abrusan, G, Yant, S, Szilágyi, A, Marsh, J, Mátés, L, Izsvák, Z, Barabás, O & Ivics, Z 2016, ' Structural determinants of Sleeping Beauty transposase activity ', Molecular Therapy . https://doi.org/10.1038/mt.2016.110
Transposases are important tools in genome engineering, and there is considerable interest in engineering more efficient ones. Here, we seek to understand the factors determining their activity using the Sleeping Beauty transposase. Recent work sugge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a17a5cd3cb6d901da1fef884bb6e3f
https://hdl.handle.net/20.500.11820/d0bd3e97-f3ba-4cb8-be5f-022613275be1
https://hdl.handle.net/20.500.11820/d0bd3e97-f3ba-4cb8-be5f-022613275be1