A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding.

Autor: Wolfe AL; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Duncan KK, Lajiness JP, Zhu K, Duerfeldt AS, Boger DL

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2013 Sep 12; Vol. 56 (17), pp. 6845-57. Date of Electronic Publication: 2013 Aug 29.

Divergent total syntheses of (-)-aspidospermine and (+)-spegazzinine.

Autor: Lajiness JP; Department of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA., Jiang W, Boger DL

Publikováno v: Organic letters [Org Lett] 2012 Apr 20; Vol. 14 (8), pp. 2078-81. Date of Electronic Publication: 2012 Apr 05.

Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation.

Autor: Lajiness JP; Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Robertson WM, Dunwiddie I, Broward MA, Vielhauer GA, Weir SJ, Boger DL

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2010 Nov 11; Vol. 53 (21), pp. 7731-8.

Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit.

Autor: Boyle KE; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA., MacMillan KS, Ellis DA, Lajiness JP, Robertson WM, Boger DL

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Mar 15; Vol. 20 (6), pp. 1854-7. Date of Electronic Publication: 2010 Feb 02.

Sequence specific and high affinity recognition of 5'-ACGCGT-3' by rationally designed pyrrole-imidazole H-pin polyamides: thermodynamic and structural studies.

Autor: Mackay H; Department of Chemistry, Hope College, 35 E. 12th Street, P.O. Box 9000, Holland, MI 49422, USA., Brown T, Uthe PB, Westrate L, Sielaff A, Jones J, Lajiness JP, Kluza J, O'Hare C, Nguyen B, Davis Z, Bruce C, Wilson WD, Hartley JA, Lee M

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2008 Oct 15; Vol. 16 (20), pp. 9145-53. Date of Electronic Publication: 2008 Sep 13.