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A pilot study of plasma metabolomic patterns from patients treated with ketamine for bipolar depression: evidence for a response-related difference in mitochondrial networks

Autor: Villaseñor, A, Ramamoorthy, A, Silva dos Santos, M, Lorenzo, M P, Laje, G, Zarate Jr, C, Barbas, C, Wainer, I W

(R,S)-ketamine produces rapid and significant antidepressant effects in approximately 65% of patients suffering from treatment-resistant bipolar depression (BD). The genetic, pharmacological and biochemical differences between ketamine responders and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a717701fffa50854ab25c486580ba510
https://europepmc.org/articles/PMC3976632/

Common genetic variation and antidepressant efficacy in major depressive disorder : a meta-analysis of three genome-wide pharmacogenetic studies

Autor: Uher, R, Tansey, KE, Rietschel, M, Henigsberg, N, Maier, W, Mors, Ole, Hauser, J, Placentino, A, Souery, D, Farmer, A, Aitchinson, KJ, Craig, I, McGuffin, P, Lewis, CM, Ising, M, Lucae, S, Binder, EB, Kloiber, S, Holsboer, F, Müller-Myhsok, B, Ripke, S, Hamilton, SP, Laje, G, McMahon, FJ, Fava, M, Rush, AJ, Perlis, RH

Publikováno v: Uher, R, Tansey, KE, Rietschel, M, Henigsberg, N, Maier, W, Mors, O, Hauser, J, Placentino, A, Souery, D, Farmer, A, Aitchinson, KJ, Craig, I, McGuffin, P, Lewis, CM, Ising, M, Lucae, S, Binder, EB, Kloiber, S, Holsboer, F, Müller-Myhsok, B, Ripke, S, Hamilton, SP, Laje, G, McMahon, FJ, Fava, M, Rush, AJ, Perlis, RH & GENDEP Investigators 2013, ' Common genetic variation and antidepressant efficacy in major depressive disorder : a meta-analysis of three genome-wide pharmacogenetic studies ', American Journal of Psychiatry, vol. 170, no. 2, pp. 207-17 . https://doi.org/10.1176/appi.ajp.2012.12020237

Objective Indirect evidence suggests that common genetic variation contributes to individual differences in antidepressant efficacy among individuals with major depressive disorder, but previous studies may have been underpowered to detect these effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ad4833b581a86ab931864f2abb5846
https://doi.org/10.1176/appi.ajp.2012.12020237