Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Laiyee Phoon"'
Autor:
Haibo Yang, Emily M. Lachtara, Xiaojuan Ran, Jessica Hopkins, Parasvi S. Patel, Xueping Zhu, Yao Xiao, Laiyee Phoon, Boya Gao, Lee Zou, Michael S. Lawrence, Li Lan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The roles of R-loops and RNA modifications in homologous recombination (HR) and other DNA double-stranded break (DSB) repair pathways remain poorly understood. Here, we find that DNA damage-induced RNA methyl-5-cytosine (m5C) modification in
Externí odkaz:
https://doaj.org/article/98680727c35b4bf0a0a9d6b0cc5aec93
Autor:
Hao Chen, Laiyee Phoon
Publikováno v:
Clinics and Research in Hepatology and Gastroenterology
Summary 2019 novel coronavirus pneumonia is a serious life-threatening disease and it has affected many people globally, especially the people who live in China. A high prevalence of hepatobiliary diseases has been observed in 2019-nCoV patients and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c210836a78943697a77091eb3a489042
https://doi.org/10.1016/j.clinre.2020.04.021
https://doi.org/10.1016/j.clinre.2020.04.021
Autor:
Haibo Yang, Yumin Wang, Yufei Xiang, Tribhuwan Yadav, Jian Ouyang, Laiyee Phoon, Xueping Zhu, Yi Shi, Lee Zou, Li Lan
Publikováno v:
Proceedings of the National Academy of Sciences. 119
RNA modifications regulate a variety of cellular processes including DNA repair.The RNA methyltransferase TRDMT1 generates methyl-5-cytosine (m5C) on messen-ger RNA (mRNA) at DNA double-strand breaks (DSBs) in transcribed regions, pro-moting transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8564e6c231d2554091acaceb1ac64966
https://doi.org/10.1073/pnas.2116251119
https://doi.org/10.1073/pnas.2116251119
Autor:
Xiangyu Wang, Jun Tan, Laiyee Phoon, Tribhuwan Yadav, Lee Zou, Li Lan, Meihan Duan, Jia-Min Zhang
Publikováno v:
Nucleic Acids Research
Reactive oxygen species (ROS) inflict multiple types of lesions in DNA, threatening genomic integrity. How cells respond to ROS-induced DNA damage at telomeres is still largely unknown. Here, we show that ROS-induced DNA damage at telomeres triggers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa049e946a2cdf1993a010a1f553dcf
http://europepmc.org/articles/PMC7026659
http://europepmc.org/articles/PMC7026659
Publikováno v:
FEBS lettersReferences. 594(9)
R-loops and G-quadruplexes (G4s) are noncanonical secondary DNA structures. Here, we show that reactive oxygen species (ROS) induce G4 formation as well as R-loops at transcriptionally active sites. Importantly, the G4 structure is subsequently trigg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b8f7424fefece1fdda2a1bf7090193
https://pubmed.ncbi.nlm.nih.gov/31977077
https://pubmed.ncbi.nlm.nih.gov/31977077