Nanomolar-potency small molecule inhibitor of STAT5 protein

Autor: D.B. Diaz, David E. Muench, Mulu Geletu, Minden, Abbarna A. Cumaraswamy, Laister Rc, Andrew M. Lewis, C.E. Brown, A. Todic, Kagan Kerman, Patrick T. Gunning, H.L. Grimes, Xin R. Cheng

Publikováno v: ACS Medicinal Chemistry Letters

© 2014 American Chemical Society. We herein report the design and synthesis of the first nanomolar binding inhibitor of STAT5 protein. Lead compound 13a, possessing a phosphotyrosyl-mimicking salicylic acid group, potently and selectively binds to S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d405ecef329f944724df3babdd41ce4
https://e-space.mmu.ac.uk/624261/

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

GNAS knockout potentiates HDAC3 inhibition through viral mimicry-related interferon responses in lymphoma.

Autor: He MY; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Tong KI; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Liu T; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Whittaker Hawkins R; Department of Immunology, University of Toronto, Toronto, ON, Canada.; Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada., Shelton V; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Zeng Y; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Bakhtiari M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Xiao Y; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA., Zheng G; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA., Sakhdari A; Laboratory Medicine and Pathobiology, University Health Network, Toronto, ON, Canada., Yang L; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Xu W; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Brooks DG; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Immunology, University of Toronto, Toronto, ON, Canada., Laister RC; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., He HH; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Kridel R; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. robert.kridel@uhn.ca.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. robert.kridel@uhn.ca.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada. robert.kridel@uhn.ca.; Department of Medicine, University of Toronto, Toronto, ON, Canada. robert.kridel@uhn.ca.

Publikováno v: Leukemia [Leukemia] 2024 Oct; Vol. 38 (10), pp. 2210-2224. Date of Electronic Publication: 2024 Aug 08.

Ex vivo activation of the GCN2 pathway metabolically reprograms T cells, leading to enhanced adoptive cell therapy.

Autor: St Paul M; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1C1, Canada., Saibil SD; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1C1, Canada. Electronic address: sam.saibil@uhn.ca., Kates M; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1C1, Canada., Han S; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1C1, Canada., Lien SC; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1C1, Canada., Laister RC; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada., Hezaveh K; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada., Kloetgen A; Department of Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Braunschweig, Germany., Penny S; Human Health Therapeutics Research Centre, National Research Council Canada, Halifax, NS, Canada., Guo T; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1C1, Canada., Garcia-Batres C; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada., Smith LK; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada., Chung DC; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1C1, Canada., Elford AR; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada., Sayad A; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada., Pinto D; Human Health Therapeutics Research Centre, National Research Council Canada, Halifax, NS, Canada., Mak TW; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada., Hirano N; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1C1, Canada., McGaha T; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1C1, Canada., Ohashi PS; Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1C1, Canada. Electronic address: pohashi@uhnresearch.ca.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2024 Mar 19; Vol. 5 (3), pp. 101465. Date of Electronic Publication: 2024 Mar 08.